GMPR

Last update 23 Jan 2025

Basic Info

Synonyms

GMP reductase 1, GMPR, GMPR 1

+ [4]

Introduction

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

100 Clinical Results associated with GMPR

100 Translational Medicine associated with GMPR

0 Patents (Medical) associated with GMPR

683

Literatures (Medical) associated with GMPR

01 Feb 2025·Environmental Research

Deciphering the internal mechanism of nitrogen removal from sludge and biofilm under low temperature from the perspective of microbial function metabolism

Article

Author: Zhao, Zhiyong ; Tang, Taotao

Nitrogen emissions up to the standard are a major challenge for wastewater treatment plants in alpine and high-altitude areas. The dosing of carriers can improve the nitrogen removal efficiency of the system at low temperatures; however, the mechanism of action of sludge and biofilm in nitrogen removal remains unclear. This study elucidated the internal mechanism of nitrogen removal via the function of microbial metabolism in sludge and biofilm at low temperatures. At low temperatures, the biofilm facilitated the enrichment of nitrifying bacteria (5.21%-6.62%) and nitrifying functional genes (amoABC); the average removal efficiency of NH₄⁺-N peaked at 94.14%. The denitrification performance of biofilm (14.34-20.67 mg N/(gMLVSS·h) was weaker than that of sludge (27-30.95 mg N/(gMLVSS·h) at low temperatures. The relative abundance of chemical oxygen demand-degrading, denitrifying bacteria, and denitrification functional genes (napAB, nirS, norB, and nosZ) in the sludge was higher than in the biofilm. With a decrease in temperature, the upregulation of carbon metabolism and quorum-sensing functional genes improved the adaptability of sludge to low temperatures. The enhancement of c-type cytochromes and cyclic dimeric guanosine monophosphate functional genes promoted nitrogen removal by endorsing extracellular electron transfer between microorganisms and releasing extracellular polymeric substances at low temperatures. This study offers new insights into improving the mechanism of nitrogen removal from sludge and biofilm at low temperatures.

01 Jan 2025·Colloids and Surfaces B: Biointerfaces

Ultrastable hierarchically porous nucleotide-based MOFs and their use for enzyme immobilization and catalysis

Article

Author: Zheng, Jiawei ; Ling, Jie ; Lin, Shuping ; Chen, Wenyi ; Zhong, Nanjing

Immobilization of free enzymes facilitates their recovery and reuse, while also enhances their enzymatic characteristics. Hierarchically porous metal-organic frameworks (HP-MOFs) are promising candidates for enzyme immobilization. However, fabrication of HP-MOFs with more kinds of components as ligands is still a challenge. Herein, ultrastable crystalline MOFs with micro-, meso- and macroporous structure were constructed using guanosine 5'-monophosphate (GMP) as organic ligand through templated emulsification method. HP-MOFs crystals with the near rhomb-like, rod-like and slab-like morphology were interestingly obtained from Zn²⁺, Cu²⁺ and Cd²⁺ respectively. The HP-MOFs immobilized enzymes exhibited an enhanced enzymatic activity and stability. In addition, the immobilized CALB (Candida antarctica lipase B) showed great glycerolysis and esterification performances for glycerides preparation, with diacylglycerols (DAG) content over 60 wt% and triacylglycerols (TAG) content over 90 wt% obtained respectively from glycerolysis and esterification. Moreover, it retained 82.32 % of its initial glycerolysis activity after six cycles of reuse in glycerolysis. The present study will provide clues and show new horizons to explore new organic ligands for HP-MOFs fabrication, as well as to expand the applications of HP-MOFs and their supported enzymes.

01 Jan 2025·Talanta

A convenient colorimetric assay for Cr(VI) detection based on homogeneous Cu(II)–GMP system with oxidoreductase-like activity

Article

Author: Yu, Yan ; Li, Ping ; Su, Xiao-Dong ; Zhou, Qian-Yu ; Liu, Lu-Lu ; Qiu, Hui-Dong ; Yan, Xu-Xia ; Song, Yi

Hexavalent chromium (Cr(VI)) is an environmental pollutant and recognized as a human carcinogen. Therefore, it is necessary to develop a simple and sensitive detection technique for Cr(VI). Herein, it is found that Cu²⁺ interacts with guanosine 5'-monophosphate (GMP) to form a homogeneous Cu(II)-GMP complex (Cu²⁺·GMP) that efficiently displays the oxidoreductase-like catalytic activity. Cu²⁺·GMP can catalyze the oxidation between Cr(VI) and substrate 3,3',5,5'- tetramethylbenzidine (TMB), resulting in color change recognized by the naked eyes. Base on this, a convenient colorimetric assay for Cr(VI) detection was developed. The detection limit (3σ/s) of this sensor for Cr(VI) was 23 nM with a linear range of 0.1-25 μM. Moreover, the proposed assay was successfully applied to detect Cr(VI) in different environmental water samples with satisfactory recoveries. Our method is simple, efficient, rapid and cost-effective for Cr(VI) detection without the need for complicated material preparation or special separation, which shows great potential in environmental monitoring.

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