SCG3

Last update 08 May 2025

Basic Info

Synonyms

FLJ90833, SCG3, secretogranin III

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Introduction

Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).

100 Clinical Results associated with SCG3

100 Translational Medicine associated with SCG3

0 Patents (Medical) associated with SCG3

131

Literatures (Medical) associated with SCG3

01 Feb 2025·Journal of Histochemistry & Cytochemistry

Dominant Expression of Chromogranin B in Pituitary Corticotrophs and Its Putative Role in Interaction With Secretogranin III

Article

Author: Yasui, Tadashi ; Kikuchi, Shota ; Gomi, Hiroshi ; Hosaka, Masahiro ; Torii, Seiji ; Odashima, Koki

Summary Previous studies have suggested that chromogranin A (CgA) is a partner molecule of secretogranin III (SgIII). In mouse pituitary corticotroph-derived AtT-20 cells, SgIII plays a role in sorting CgA/hormone aggregates into secretory granules (SGs). Although CgA expression is equivocal, CgB is clearly detectable in the rat pituitary corticotrophs. Therefore, we hypothesized that CgB shares a function with CgA in pituitary corticotrophs. In the binding assays, CgB, similar to CgA, showed binding activity to SgIII under weakly acidic conditions and in the presence of Ca2+. Considering the differences in animal species, the different abilities of antibodies, and the conditions of tissue fixation and thin sectioning in immunofluorescence histochemistry, we found that CgA was expressed in a small population (approximately 10%), and its expression intensity was weaker than that of CgB (>98%) in rodent pituitary corticotrophs. In addition, similar to CgA, CgB and SgIII were colocalized in adrenocorticotropic hormone (ACTH) granules. The labeling of CgA and CgB was not completely consistent, and CgB colocalized with SgIII in many granules. These results suggest that there are multiple sorting systems for ACTH granules in pituitary corticotrophs and that the SgIII/CgB complex behaves more dominantly than the SgIII/CgA complex, which has somewhat different properties:

01 Jan 2025·Journal of Diabetes Investigation

Precision medicine in diabetes prediction: Exploring a subgroup‐specific biomarker strategy for risk stratification

Article

Author: Heng‐Huei, Lin ; Chen, Szu‐Chi ; Fan, Kang‐Chih ; Hsu, Chih‐Yao ; Lyu, Ya‐Pin ; Kuo, Chun‐Heng ; Li, Hung‐Yuan ; Juan, Hsien‐Chia ; Yang, Chung‐Yi ; Lin, Mao‐Shin ; Lin, Chia‐Hung ; Yen, I‐Weng

ABSTRACTIntroductionThe early detection of high‐risk individuals is crucial to delay and reduce the incidence of type 2 diabetes. In this study, we aimed to explore the performance of a novel subgroup‐specific biomarker strategy in the prediction of incident diabetes.Materials and MethodsIn the Taiwan Lifestyle Cohort Study, adult subjects without diabetes were included and followed for the incidence of diabetes in 2006–2019. The biomarkers measured included blood secretogranin III (SCG3), vascular adhesion protein‐1 (VAP‐1), fibrinogen‐like protein 1 (FGL1), angiopoietin‐like protein 6 (ANGPTL6), and angiopoietin‐like protein 4 (ANGPTL4).ResultsAmong the 1,287 subjects, 12.2% developed diabetes during a 6 year follow‐up. Blood VAP‐1 was significantly associated with incident diabetes in the overall population (HR = 0.724, P < 0.05), participants under 65 years old (HR = 0.685, P < 0.05), those with a BMI of ≥24 kg/m2 (HR = 0.673, P < 0.05), and females (HR = 0.635, P < 0.05). Blood ANGPTL6 was significantly correlated with incident diabetes in participants aged 65 and older (HR = 0.314, P < 0.05), and blood SCG3 was associated with incident diabetes in those with a BMI of <24 kg/m2 (HR = 1.296, P < 0.05). Two subgroup‐specific biomarker strategies were developed. The gender and BMI‐specific biomarker strategy, using traditional risk factors and blood SCG3 or VAP‐1 in different subgroups, could improve prediction performance, especially the specificity and positive prediction value, compared with the whole‐population strategy using only traditional risk factors or traditional risk factors plus blood VAP‐1.ConclusionGender‐ and BMI‐specific biomarker strategy can improve the prediction of incident diabetes. A subgroup‐specific biomarker strategy is a novel approach in the prediction of incident diabetes.

01 Jan 2025·Journal of Investigative Dermatology

Identifying Potential Drug Targets for Keloid: A Mendelian Randomization Study

Article

Author: Luo, Xusong ; Wang, Yinmin ; Yuan, Zhaoqi ; Liu, Fei ; Wang, Xiuxia ; Yang, Jun

Keloids are a skin fibrosis disease characterized by troublesome symptoms, a varying degree of recurrence and inevitable side effects from treatments. Thus, identifying their drug targets is necessary. A 2-sample Mendelian randomization analysis was conducted using proteins from the intersection of the deCODE database and "The Druggable Genome and Support for Target Identification and Validation in Drug Development" as the exposure variable. The outcome variable was based on recently published GWAS of keloids. Summary data-based Mendelian randomization and colocalization analysis was employed to distinguish pleiotropy from linkage. Candidate targets underwent drug target analysis. The primary findings were validated through single-cell RNA-sequencing data, Western Blot and immunofluorescence staining on keloids. Seven proteins were identified as potential drug targets for keloids. Among these proteins, Hedgehog-interacting protein, neurotrimin [NTM], KLKB1, and CRIPTO showed positive correlations with keloids, while PLXNC1, SCG3 and PDGFD exhibited negative correlations. Combined with the single-cell RNA-sequencing data, NTM, PLXNC1, and PDGFD were found highly expressed in the fibroblasts. NTM showed a significant increase in keloids as compared to normal scars. In accordance with the analysis, higher levels of protein expression of NTM in keloids compared to normal skin was observed. The identified proteins may be appealing drug targets for keloids treatment with a special emphasis on NTM.

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SCG3

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