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LOS ANGELES, Dec. 18, 2024 /PRNewswire/ -- Pharus Diagnostics LLC. (PharusDx), an innovator in non-invasive diagnostic tests, today announced a significant step forward in the fight against pancreatic cancer. The company is announcing availability of its OncoSweep™ Pancreas Spotlight, a liquid biopsy screening test that aids in the detection of Pancreatic Ductal Adenocarcinoma (PDAC) in people with elevated risk. The test uses a simple blood sample, next-generation sequencing, and a proprietary machine learning pipeline to analyze levels of microRNA and CA19-9 biomarkers. In January of 2024, PharusDx entered into an exclusive global licensing agreement with City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States with a Los Angeles comprehensive cancer center ranked among the nation's top 5 cancer centers by U.S. News & World Report, for a proprietary panel of microRNA (miRNA) biomarkers with testing data demonstrating potential value for early detection of PDAC. OncoSweep™ Pancreas Spotlight builds on the biomarker panel and approach from City of Hope, moving the translational academic findings into a Laboratory Developed Test (LDT). This effort leverages PharusDx's OncoSweep™ liquid biopsy platform and City of Hope's groundbreaking early cancer detection research led by Dr. Ajay Goel, Chair of City of Hope's Department of Molecular Diagnostics and Experimental Therapeutics. "We have been hard at work validating our pancreatic cancer miRNA biomarker panel and have now completed CLIA[1] LDT validation of our test, an exciting milestone for the company and people at-risk who have limited options for early detection of this devastating disease" explained CEO Philip Huang. "We are thrilled to bring this potentially life-saving technology developed by PharusDx, based on translational research findings from City of Hope, to market," said Bowei Lee, Chairman of PharusDx. "An accurate early detection tool can significantly improve outcomes for people with PDAC, particularly when surgical intervention remains a viable option." Combating a Deadly Disease PDAC is an aggressive form of cancer with a dismal prognosis. Due to its location within the body and lack of early symptoms, the disease is often diagnosed at an advanced stage, significantly reducing survival rates. Most PDAC is detected at stage IV when there is just a 3%[2],[3] five-year survival rate. If the disease is caught at stage I, the five-year survival jumps to over 40%[2], a greater than 10-fold increase. Those at increased risk for PDAC include people with Lynch syndrome, Peutz-Jeghers syndrome, new-onset diabetes (after 50 yrs old), pancreatic cysts, chronic pancreatitis, certain mutations in BRCA1/2, PRSS1, ATM, TP53, those with first degree relatives as well as those with certain lifestyle risk factors such as smoking, alcohol abuse, or obesity. A Brighter Future for Patients PharusDx's new OncoSweep™ Pancreas Spotlight LDT has the potential to significantly improve outcomes by offering a non-invasive and accurate screening method for early-detection. The development of this LDT, in conjunction with PacificDx (a CLIA-accredited laboratory) in Irvine, California, aligns with PharusDx's commitment to advancing early cancer detection. By offering a simple blood test for PDAC, the company aims to empower individuals at risk for the disease to undergo regular monitoring to detect early-stage disease when they have the most options for treatment. References and Notes About PharusDx PharusDx is at the forefront of healthcare innovation, specializing in advanced diagnostic technologies. Founded in 2022, our mission is to detect cancer early to help provide more treatment options and improve patient outcomes. Our focus is to create exceptionally precise and accurate tests by integrating liquid biopsies, advanced biomarkers and machine learning. OncoSweep™ early detection tests are designed to be convenient and accessible, with the patient always at the center. For more information on PharusDx visit or connect on LinkedIn: For media/investor inquiries/partnership, please contact: [email protected] Conflict of Interest Statement: Dr. Goel is a compensated PharusDX advisory board member and as an inventor of the technology licensed to the company by City of Hope, is entitled to royalty payments from the company. SOURCE Pharus Diagnostics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

— Series B led by Goldman Sachs Alternatives with participation from Fidelity Management & Research Company, Deep Track Capital, and existing investors — — Funding will advance second-generation anti-kallikrein 5/7+IL-13 bispecific (TRIV-573) through clinical proof-of-concept — — Lead antibody program TRIV-509 IND submission on track for 1Q 2025 — WATERTOWN, MA, USA I October 2, 2024 I Triveni Bio Inc., a biotech company advancing novel antibody treatments for I&I disorders, today announced a $115 million Series B to support pipeline expansion. The round was led by Goldman Sachs Alternatives with significant participation from additional new investors Fidelity Management & Research Company and Deep Track Capital, and Series A investors Atlas Venture, Cormorant Asset Management, OrbiMed, Viking Global Investors, and Invus. “We have built a differentiated pipeline of novel drug targets,” said Vishal Patel, Ph.D., Chief Executive Officer of Triveni Bio. “The Series B accelerates our pipeline expansion, particularly for our bispecific program, TRIV-573, which uniquely combines two orthogonal mechanisms of action.” The Series B financing follows a $92 million Series A completed less than a year ago. In addition to pipeline advancement, Triveni is expanding its data science platform with a focus on precision dermatology and strengthening its leadership team – most recently with the appointment of Bhaskar Srivastava, M.D., Ph.D., as Chief Medical Officer. “We have been impressed with the team’s progress towards becoming a clinical stage organization for I&I disorders where standard of care is lacking,” said Josh Richardson M.D., Managing Director within Goldman Sachs Alternatives. “We look forward to supporting both programs through clinical proof-of-concept and beyond.” Triveni plans to submit an Investigational New Drug (IND) application for its lead candidate, TRIV-509, in the first quarter of 2025. TRIV-509 is a monoclonal antibody inhibitor targeting kallikreins 5 and 7 (KLK 5/7) that has demonstrated superior efficacy compared to IL-4R inhibition in multiple preclinical atopic dermatitis models. TRIV-573 combines KLK 5/7 inhibition with a well-established IL-13 mechanism. Triveni continues to explore additional innovative combinations to further enhance treatment outcomes. The company is also advancing an antibody inhibitor of trypsin 1 and 2 for the treatment of hereditary pancreatitis, a genetic disorder predominantly caused by PRSS1 mutations. Hereditary pancreatitis, which currently has no approved treatments, impacts around 10,000 individuals in the United States. About Triveni Bio Triveni Bio is a biotechnology company at the forefront of novel antibody-based therapies for immunological and inflammatory disorders. Using a genetics-informed, precision medicine approach, the company seeks to establish proof-of-concept early in the drug development process by leveraging deep insights into genetic and mechanistic biology. To learn more, visit www.triveni.bio . SOURCE: Triveni Bio