CGRP x NK1R

Last update 08 May 2025

Basic Info

Related Targets

CGRPNK1R

100 Clinical Results associated with CGRP x NK1R

100 Translational Medicine associated with CGRP x NK1R

0 Patents (Medical) associated with CGRP x NK1R

1,756

Literatures (Medical) associated with CGRP x NK1R

01 Jun 2025·Archives of Oral Biology

Sensory innervation of rat molar root pulp and dentin, apex, foramen, cellular cementum, vasculature and periodontium

Article

Author: Byers, Margaret R

OBJECTIVETrigeminal innervations of dental roots have only been partly investigated. The aim of this study was to document sensory innervation of rat molar roots, especially their neural patterns in periapical tissues that may affect tooth pain.DESIGNTrigeminal nerve ending patterns in young and old rat molars that had been labeled by tritiated axonal-transported protein were compared by immunocytochemistry for neural peripherin, calcitonin gene-related peptide, p75-neurotrophin receptor, synaptophysin, Substance P, and neurofilament-200.RESULTSNine sensory nerve patterns were found in the autoradiograms: (1) PERIAPICAL PULP had large axons ending among odontoblasts, other axons with free endings in pulp, plus innervation of dentin on the palatal-lingual and buccal sides of each root. (2) CELLULAR CEMENTUM MATRIX (CCx) had small nerve channels extending across from periodontium to apex, plus trigeminal endings in the CCx at its apical and periodontal edges. (3) THE FORAMEN REGION had many free axons plus much vascular innervation. (4) THE APEX had a variety of axons ending along its walls. (5) NEARBY PERIODONTIUM had neurovascular clusters including trigeminal axons and Ruffini mechanoreceptors near the foramen. Immunocytochemistry showed that CGRP, peripherin, synaptophysin, and p75-neurotrophin receptor each had individual neural patterns in periapical tissues, while Substance P and neurofilament protein were more limited. Differences between lateral and accessory canals were noted.CONCLUSIONThe nine periapical trigeminal innervation patterns identified so far differ from crown and root shaft. They likely have important effects on tooth pain in general and on periapical pains that can be difficult to anesthetize and treat.

01 Apr 2025·Journal of Ethnopharmacology

Mechanistic exploration of licorice reconciling Medicine:Huangqi Guizhi Wuwu decoction and Shaoyao Gancao decoction compatibility as an example

Article

Author: Peng, Guoping ; Cheng, Xiaolan ; Zheng, Yunfeng ; Li, Cunyu ; Cao, Peng ; Fu, Shengnan ; Tang, Shuwan

ETHNOPHARMACOLOGICAL RELEVANCEGlycyrrhiza uralensis Fisch. (GU) is a pivotal botanical in traditional Chinese medicine (TCM), because of its ability to reconcile various herbs, and its crucial role in numerous formulas. Huanggui Shaogan decoction (HSGD) is an empirical formula, developed by Huangqi Guizhi Wuwu decoction (HGD) and Shaoyao Gancao decoction (SGD), and prepared by adding GU to HGD. However, the mechanisms of GU reconciling medicine remain incompletely characterized.AIM OF THE STUDYThis study aimed to explain mechanisms of GU reconciling medicine based on the differences of components, pharmacological efficacy, and the existence of the components.METHODSDifferential components between HSGD and HGD were systematically identified using LC‒MS/MS coupled with chemometric analysis. The existence states and binding affinities of these differential components were further characterized via ultrafiltration separation. The therapeutic potential of HSGD was validated in a murine model of oxaliplatin-induced peripheral neuropathy (OIPN).RESULTSTwenty-two differential chemical components between HSGD and HGD were identified, including flavonoids, saponins, gingerol, and monoglycoside. The transmittance of flavonoids and gingerols increased in HSGD. However, the transmittance of astragalus saponins decreased, which may be due to micelle association and the increase in molecular clusters. HSGD could enhance the mechanical pain threshold, alleviate cold nociceptive hypersensitivity, relieve dorsal root ganglia neuron injury, and decrease the expression of nerve growth factor, 5-hydroxytryptamine, substance P, and calcitonin gene-related peptide better. The differential correlation analysis revealed the relationship between differential components and pharmacological indicators. The above results indicated that different herbs combinations had a greater impact on the dissolution and molecular state of the components of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao.CONCLUSIONThe study highlights the solubilizing effect of GU within HSGD, and it also improves the efficacy of the treatment of OIPN, which underpins its compatibility rationality. It provided an inspiration for the study of other TCM formulas.

01 Apr 2025·Cytokine & Growth Factor Reviews

Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation

Review

Author: Zhang, Ying-Ru ; Wang, Yan ; Li, Ying ; Yang, Sheng-Ya

The nervous and immune systems are two major components that maintain body homeostasis, with their functional roles often overlapping significantly. Both systems are capable of identifying, integrating, and organizing responsive reactions to various external stimuli. The gut, referred to as the "second brain" and the largest immune organ in the body, serves as the most frequent focal site for neuroimmune interactions. Colorectal cancer (CRC), as the predominant solid tumor arising in this neuroimmune-rich microenvironment, remains understudied through the lens of neuroimmune regulatory mechanisms. This review systematically synthesizes current evidence to elucidate the neuroimmune axis in CRC pathogenesis, with particular emphasis on neuroimmune crosstalk-mediated remodeling of tumor immunity. We comprehensively catalog the immunomodulatory effects exerted by principal neuroregulatory mediators, categorized as: (1) neurotransmitters (glutamate, glutamine, γ-aminobutyric acid, epinephrine, norepinephrine, dopamine, serotonin, acetylcholine, and gaseous signaling molecules); (2) neuropeptides (substance P, calcitonin gene-related peptide, vasoactive intestinal peptide); and (3) neurotrophic factors. Furthermore, we critically evaluate the translational prospects and therapeutic challenges of targeting neuroimmune pathways and propose strategic priorities and research focuses for advancing the development of neuroimmune interaction-related therapeutic approaches in CRC.

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