OR1G1

Last update 23 Jan 2025

Basic Info

Synonyms

Olfactory receptor 17-209, Olfactory receptor 1G1, Olfactory receptor 1G2

+ [5]

Introduction

Odorant receptor.

100 Clinical Results associated with OR1G1

100 Translational Medicine associated with OR1G1

0 Patents (Medical) associated with OR1G1

Literatures (Medical) associated with OR1G1

01 Jan 2024·Chemical Senses

Effects of genetics on odor perception: Can a quick smell test effectively screen everyone?

Article

Author: Hannum, Mackenzie E ; Parma, Valentina ; Nguyen, Ha ; Bell, Katherine ; Dalton, Pamela H ; Lin, Cailu ; Huang, Amy ; Joseph, Paule V ; Reed, Danielle R ; Hunter, Stephanie R

AbstractSCENTinel, a rapid smell test designed to screen for olfactory disorders, including anosmia (no ability to smell an odor) and parosmia (distorted sense of smell), measures 4 components of olfactory function: detection, intensity, identification, and pleasantness. Each test card contains one of 9 odorant mixtures. Some people born with genetic insensitivities to specific odorants (i.e. specific anosmia) may fail the test if they cannot smell an odorant but otherwise have a normal sense of smell. However, using odorant mixtures has largely been found to prevent this from happening. To better understand whether genetic differences affect SCENTinel test results, we asked genetically informative adult participants (twins or triplets, N = 630; singletons, N = 370) to complete the SCENTinel test. A subset of twins (n = 304) also provided a saliva sample for genotyping. We examined data for differences between the 9 possible SCENTinel odors; effects of age, sex, and race on SCENTinel performance, test–retest variability; and heritability using both structured equation modeling and SNP-based statistical methods. None of these strategies provided evidence for specific anosmia for any of the odors, but ratings of pleasantness were, in part, genetically determined (h2 = 0.40) and were nominally associated with alleles of odorant receptors (e.g. OR2T33 and OR1G1; P < 0.001). These results provide evidence that using odorant mixtures protected against effects of specific anosmia for ratings of intensity but that ratings of pleasantness showed effects of inheritance, possibly informed by olfactory receptor genotypes.

01 Jan 2024·Journal of Oleo Science

Nutritional and Volatile Fingerprint Characteristics of an Amazon Fruit: <i>Ficus subapiculata</i>

Article

Author: Aguiar, Jaime P. Lopes ; Amaral, Ana Claudia F. ; Souza, Francisca das Chagas do A. ; H. de Almeida, Maíra Martins ; Lima, Camilo Henrique da S. ; Corrêa, Pollyane G. ; Moura, Leonardo G. Sanders ; Silva, Jefferson R. de Andrade

Ficus subapiculata is distributed throughout the Amazon region, although its potential for commercial fruit production has not yet been explored. We describe here the chemical and nutritional composition of F. subapiculata fruits and some aspects of the postharvest maturation. The fruits are low in calories (69.83 kcal), have moderate carbohydrate content (15.1 g/100 g), and a high moisture content (82.15 g/100 g), with physicochemical properties and an organic acid profile that classify them as acidic. After 72 hours of observation at room temperature, fresh fruits exhibited signs of deterioration, such as color changes and weight due to senescence, making them unsuitable for consumption. Forty-five volatile organic compounds (VOCs) were identified in the fresh fruits through headspace analysis, most belonging to the terpenoid class of aromatic notes. Over 96 hours of observation, the fruits showed variations in their volatile compound profiles and a significant decrease in total VOCs content. The compounds that bound most strongly to the olfactory receptor in a docking study, such as germacrene D, also had the strongest odorcausing effects. The results suggest that the ability of aromatic notes to influence the olfactory perception of fruit is related to how well they fit and interact with the OR1G1 target protein. Finally, the chemical constituents and nutritional composition of F. subapiculata fruits were determined, and their 96 h of observation period at room temperature was evaluated. These findings provided important information for a better understanding of the nutritional potential and properties of this fruit.

02 Nov 2023·Brain

Large-scale rare variant burden testing in Parkinson's disease

Article

Author: Hardy, John ; Serrano, Geidy E ; Real, Raquel ; Solsberg, Caroline Warly ; Makarious, Mary B ; Iwaki, Hirotaka ; Leonard, Hampton L ; Alvarado, Chelsea X ; Morris, Huw R ; Pitz, Vanessa ; Ding, Jinhui ; Beach, Thomas G ; Ye Fu, Allen ; Scholz, Sonja W ; Tanaka, Toshiko ; Ferrucci, Luigi ; Dalgard, Clifton L ; Blauwendraat, Cornelis ; Lake, Julie ; Guidubaldi, Joseph L ; Bhangale, Tushar ; Kim, Jonggeol Jeffrey ; Torkamani, Ali ; Grenn, Francis P ; Ehrlich, Debra J ; Vitale, Dan ; Gibbs, J Raphael ; Bandres-Ciga, Sara ; Billingsley, Kimberley J ; Ta, Michael ; Ryten, Mina ; Nalls, Mike A ; Hernandez, Dena ; Singleton, Andrew B ; Traynor, Bryan J ; Jerez, Pilar Alvarez

AbstractParkinson’s disease has a large heritable component and genome-wide association studies have identified over 90 variants with disease-associated common variants, providing deeper insights into the disease biology. However, there have not been large-scale rare variant analyses for Parkinson’s disease.To address this gap, we investigated the rare genetic component of Parkinson’s disease at minor allele frequencies <1%, using whole genome and whole exome sequencing data from 7184 Parkinson’s disease cases, 6701 proxy cases and 51 650 healthy controls from the Accelerating Medicines Partnership Parkinson's disease (AMP-PD) initiative, the National Institutes of Health, the UK Biobank and Genentech. We performed burden tests meta-analyses on small indels and single nucleotide protein-altering variants, prioritized based on their predicted functional impact.Our work identified several genes reaching exome-wide significance. Two of these genes, GBA1 and LRRK2, have variants that have been previously implicated as risk factors for Parkinson’s disease, with some variants in LRRK2 resulting in monogenic forms of the disease. We identify potential novel risk associations for variants in B3GNT3, AUNIP, ADH5, TUBA1B, OR1G1, CAPN10 and TREML1 but were unable to replicate the observed associations across independent datasets. Of these, B3GNT3 and TREML1 could provide new evidence for the role of neuroinflammation in Parkinson’s disease. To date, this is the largest analysis of rare genetic variants in Parkinson’s disease.

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OR1G1

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