Last update 01 Nov 2024

GOT1L1

Last update 01 Nov 2024

Basic Info

Synonyms

Glutamate oxaloacetate transaminase 1-like protein 1, glutamic-oxaloacetic transaminase 1 like 1, GOT1L1

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Introduction-

100 Clinical Results associated with GOT1L1

100 Translational Medicine associated with GOT1L1

0 Patents (Medical) associated with GOT1L1

Literatures (Medical) associated with GOT1L1

30 Jun 2024·Rapid Communications in Mass Spectrometry

Simultaneous quantification of six proteins related to liver injury using nano liquid chromatography–tandem mass spectrometry

Article

Author: Yan, Binjun ; Su, Yuan ; Shi, Mengtian ; Cai, Siyu ; Wang, Dandan ; Chen, David Da Yong

RationaleIn clinical diagnosis of liver injury, which is an important health concern, serum aminotransferase assays have been the go‐to method used worldwide. However, the measurement of serum enzyme activity has limitations, including inadequate disease specificity and enzyme specificity.MethodsWith the high selectivity and specificity provided by nano liquid chromatography–tandem mass spectrometry (LC/MS/MS), this work describes a method for the simultaneous determination of six proteins in liver that can be potentially used as biomarkers for liver injury: glutamic‐pyruvic transaminase 1 (GPT1), glutamic oxaloacetic transaminase 1 (GOT1), methionine adenosyl transferase 1A (MAT1A), glutathione peroxidase 1 (GPX1), cytokeratin 18 (KRT18) and apolipoprotein E (APOE).ResultsIn validation, the method was shown to have good selectivity and sensitivity (limits of detection at pg/mL level). The analytical method revealed that, compared with normal mice, in carbon tetrachloride‐induced acute liver injury mice, liver MAT1A and GPX1 were significantly lower (p < 0.01 and p < 0.05, respectively), KRT18 was significantly higher (p < 0.05) and APOE and GPT1 were marginally significantly lower (p between 0.05 and 0.1). This is the first work reporting the absolute contents of GPT1, GOT1, MAT1A, GPX1 and KRT18 proteins based on LC/MS.ConclusionsThe proposed method provides a basis for establishing more specific diagnostic indicators of liver injury.

01 Dec 2022·BMC Genomics

Ectopic expression of a combination of 5 genes detects high risk forms of T-cell acute lymphoblastic leukemia

Article

Author: Cheng, Zhong-Yi ; Xi, Meng-Ping ; Zhou, Yue-Bo ; Zhang, Jiao-Jiao ; Peng, Li-Jun ; Geng, Mei ; Rousseaux, Sophie ; Wang, Jin ; Liu, Yuan-Fang ; Chuffart, Florent ; Khochbin, Saadi ; Wang, Tao ; Mi, Jian-Qing ; Chen, Bing ; Gao, Meng-Qing ; Zhang, Wei-Na ; Bourova-Flin, Ekaterina

AbstractBackgroundT cell acute lymphoblastic leukemia (T-ALL) defines a group of hematological malignancies with heterogeneous aggressiveness and highly variable outcome, making therapeutic decisions a challenging task. We tried to discover new predictive model for T-ALL before treatment by using a specific pipeline designed to discover aberrantly active gene.ResultsThe expression of 18 genes was significantly associated with shorter survival, including ACTRT2, GOT1L1, SPATA45, TOPAZ1 and ZPBP (5-GEC), which were used as a basis to design a prognostic classifier for T-ALL patients. The molecular characterization of the 5-GEC positive T-ALL unveiled specific characteristics inherent to the most aggressive T leukemic cells, including a drastic shut-down of genes located on the mitochondrial genome and an upregulation of histone genes, the latter characterizing high risk forms in adult patients. These cases fail to respond to the induction treatment, since 5-GEC either predicted positive minimal residual disease (MRD) or a short-term relapse in MRD negative patients.ConclusionOverall, our investigations led to the discovery of a homogenous group of leukemic cells with profound alterations of their biology. It also resulted in an accurate predictive tool that could significantly improve the management of T-ALL patients.

01 Feb 2022·European Journal of PharmacologyQ3 · MEDICINE

Glutamic oxaloacetic transaminase 1 as a potential target in human cancer

Q3 · MEDICINE

Review

Author: Wu, Yanli ; Song, Zhuorui ; Sun, Dejuan ; Chen, Lixia ; Yang, Yueying ; Zheng, Mengzhu ; Li, Hua

Glutamic Oxaloacetic Transaminase 1 (GOT1) is one distinct isoenzyme of glutamic oxaloacetic transaminase in eukaryotic cells, which is located in the cytoplasm. To date, several studies have shown that GOT1 plays a critical role in regulating cell proliferation by participating in amino acid metabolism, especially in glutamine metabolism. In addition, GOT1 is overexpressed in many cancer, so GOT1 has been identified as a potentially therapeutic target. Herein, this review summarizes the structure and function of GOT1 and the important roles of GOT1 in some tumor progress, as well as the characterization of GOT1 inhibitors. It may provide new insight into the discovery of small compounds as potential anti-GOT1 drugs for treatment of cancer.

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GOT1L1

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