SLC7A4

Last update 08 May 2025

Basic Info

Synonyms

CAT-4, CAT4, Cationic amino acid transporter 4

+ [7]

Introduction

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

100 Clinical Results associated with SLC7A4

100 Translational Medicine associated with SLC7A4

0 Patents (Medical) associated with SLC7A4

1,997

Literatures (Medical) associated with SLC7A4

01 May 2025·Developmental & Comparative Immunology

Exploration of the differential expression patterns of immunoglobulin heavy chain genes in horses and donkeys

Article

Author: Yi, Xiaohua ; Sun, Xiuzhu ; Wang, Shuhui ; Jiang, Junyi ; Qiu, Yanbo

This study investigated the immunoglobulins (IG) gene locus structure and expression diversity in local Chinese horse and donkey breeds, including Ningqiang, Guanzhong horses, and varieties such as Guanzhong, Jiami, and Northern Shaanxi donkey using genome alignment and high-throughput sequencing. The aim was to expand understanding of IG expression patterns in horses, donkeys, and their different breeds. The results revealed that the donkey IGH locus contains 117 VH genes (23 functional), 44 DH genes, and 8 JH genes, arranged in a VH-DH-JH sequence on chromosome 7, spanning approximately 1189 kb. Both horses and donkeys exhibited high frequencies of the IGHV4-IGHD2-IGHJ6, IGHV4-IGHD4-IGHJ6, and IGHV4-IGHD2-IGHJ4 combinations during VDJ recombination. Significant differences in V, D, and J junctions between horses and donkeys, as well as among breeds, were observed, mainly due to variations in N-nucleotide insertion length. The CDR3H region in horses exhibited greater length diversity and a higher Cys content than that in donkeys, which may contribute to species-specific differences in IGH spatial structure. Both horses and donkeys showed a clear preference for A > G and G > A mutations during somatic hypermutation (SHM), with consistent trends across breeds and species. In conclusion, this study reveals that V(D)J recombination, junction diversity, and SHM are key mechanisms driving IGH diversity in horses and donkeys. While the basic mechanisms for IGH diversification are similar across species and breeds, their specific manifestations exhibit both distinct and consistent patterns, reflecting differences in immune system adaptations and providing a theoretical basis for understanding IGH expression diversity in equids.

15 Apr 2025·ACS Nano

Hierarchical Assembly of Hemin-Peptide Catalytic Systems on Graphite Surfaces

Article

Author: Hayamizu, Yuhei ; Nabae, Yuta ; Fukuma, Takeshi ; Uenodan, Nina ; Yurtsever, Ayhan ; Sugiyama, Marie

The formation of molecular hybrid systems with cofactors and peptides on graphite electrodes has recently been demonstrated. The design of peptide sequences is crucial for forming robust catalytic molecular systems on electrodes. However, the relationship between peptide sequences, molecular structure, and catalytic performance has not been fully explored. In this study, we employed peptides with simple dipeptide repeats, which effectively immobilize hemin, to construct a stable catalytic system and investigated the molecular basis of their self-assembly and catalytic activity by varying the sequence. Among peptides containing the dipeptide sequences (YH, VH, and LH), YH demonstrated the most efficient immobilization of hemin, which is catalytically active in electrochemical reactions. Using advanced molecular visualization techniques, specifically frequency modulation atomic force microscopy (FM-AFM), we characterized the well-ordered structures of these peptides on graphite electrodes, revealing their molecular-scale organization. Our findings in electrochemical characterizations include a quantitative evaluation of the surface density of hemin immobilized by self-assembled peptides and the catalytic activity of the peptide-hemin hybrid system under electrochemical conditions in the presence of H₂O₂. The strong peptide-peptide and peptide-hemin interactions, facilitated by π-π interactions of tyrosine residues, contribute to the system's stability and efficiency. The dipeptide repeats serve as a useful platform to investigate the role of important amino acids, beyond histidine, in stably immobilizing cofactors. These results highlight the potential for developing durable and efficient catalytic interfaces in electrochemical applications.

01 Feb 2025·Experimental Dermatology

IgG Signalling Involves in Skin Inflammation of Atopic Dermatitis

Article

Author: Mao, Liya ; Xu, Jing ; Yao, Xu ; Li, Wei ; Gu, Chaoyin ; Shen, Xiaotian ; Chen, Xingyu ; Wang, Shangshang ; Zhu, Ronghui ; Yin, Huibin

ABSTRACTAtopic dermatitis (AD) patients usually have elevated serum IgE that is thought inducing inflammation upon binding to allergen. However, the role of IgE‐producing B cells and other isotypes of immunoglobulin, such as IgG, in AD are not clear and rarely explored. This study aimed to investigate the role of IgE‐producing B cells and other isotypes of immunoglobulin, particularly IgG, in skin lesion of AD. BCR repertoires were analysed using mRNA prepared from skin lesions and peripheral blood mononuclear cells (PBMCs) from AD patients and non‐allergic healthy subjects. Single‐cell RNA sequencing data of AD lesions from published literature were extracted to analyse the function of IgG. BCR repertoires from skin lesion and PBMCs clustered distinctly, and PBMCs showed higher interindividual similarity compared to those from the skin. The proportions of IGHM, IGHD, IGHA, IGHG and IGHE varied among skin lesion and PBMCs of AD patients and healthy individuals, and IGHG was significantly increased in AD lesion. IGHG showed biased VH usage, with dominance of V1‐58, V1‐8, V3‐13 and V3‐73. The much higher hyperexpanded clonality and lower diversity of IGHG repertoire in skin than those of the PBMCs, suggested the clonal expansion of IgG+ B cells in the skin. Pathways related with IgG activation were enriched in AD skin, and macrophages may be activated by IgG and promote skin inflammation. In conclusion, skin is not the main production site for IgE in AD. IgG may involve in promoting Th2 inflammation in AD skin through macrophages.

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SLC7A4

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