PPIE

Last update 08 May 2025

Basic Info

Synonyms

Cyclophilin E, Cyclophilin-33, CyP-33

+ [8]

Introduction

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:18258190, PubMed:20460131, PubMed:20677832, PubMed:8977107). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:18258190, PubMed:20460131, PubMed:8977107). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:18258190, PubMed:20541251, PubMed:20677832, PubMed:8977107). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20460131, PubMed:20541251, PubMed:20677832).

100 Clinical Results associated with PPIE

100 Translational Medicine associated with PPIE

0 Patents (Medical) associated with PPIE

Literatures (Medical) associated with PPIE

01 May 2025·Journal of Applied Toxicology

Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis

Review

Author: Pan, Yan ; Alshawsh, Mohammed Abdullah ; Alshagga, Mustafa ; Lim, Sharoen Yu Ming ; Peter, Angela Paul ; Lim, Willone

AbstractThe CYP33 family in Caenorhabditis elegans is integral to processes like xenobiotic detoxification, eicosanoid regulation, nanotoxicity response and spermatogenesis. Limited research on C. elegans CYP33 suggests its functions are similar to human CYP33, indicating conserved roles in metabolism and disease. This review examines C. elegans CYP33 enzymes, especially CYP‐33E1 and CYP‐33E2, and their human homologues, focusing on their roles in eicosanoid biosynthesis, xenobiotic metabolism, nanotoxicity and spermatogenesis. Understanding these enzymes enhances insights into cytochrome P450 biology, metabolism and cyp‐associated diseases.

01 Dec 2024·Cell

Organ-specific electrophile responsivity mapping in live C. elegans

Article

Author: Long, Marcus J C ; Novotny, Balázs Á. ; Liu, Jinmin ; Kulkarni, Amogh ; Gao, Yong-Qi ; Urul, Daniel A. ; Novotny, Balázs Á ; Hamelin, Romain ; Long, Marcus J.C. ; Urul, Daniel A ; Aye, Yimon

Proximity labeling technologies are limited to indexing localized protein residents. Such data-although valuable-cannot inform on small-molecule responsivity of local residents. We here bridge this gap by demonstrating in live C. elegans how electrophile-sensing propensity in specific organs can be quantitatively mapped and ranked. Using this method, >70% of tissue-specific responders exhibit electrophile responsivity, independent of tissue-specific abundance. One responder, cyp-33e1-for which both human and worm orthologs are electrophile responsive-marshals stress-dependent gut functions, despite manifesting uniform abundance across all tissues studied. Cyp-33e1's localized electrophile responsivity operates site specifically, triggering multifaceted responses: electrophile sensing through the catalytic-site cysteine results in partitioning between enzyme inhibition and localized production of a critical metabolite that governs global lipid availability, whereas rapid dual-cysteine site-specific sensing modulates gut homeostasis. Beyond pinpointing chemical actionability within local proteomes, organ-specific electrophile responsivity mapping illuminates otherwise intractable locale-specific metabolite signaling and stress response programs influencing organ-specific decision-making.

01 Oct 2024·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Multi-omics genetic association analysis identifies susceptibility risk gene of acute viral respiratory infections in multi-ancestry populations and screening of potential traditional Chinese medicines].

Article

Author: Zheng, Xiao-Hong ; Tian, Xin-Yu ; Chu, Bo-Wen ; Wang, Xiao-Ya ; Yue, Zeng-Ya-Ran ; Ding, Chen-Yu ; Li, Zi-Mo ; Tang, Xin-Hao ; Zhang, Yi-Miao ; Ding, Hao-Yu ; Chu, Rong

The investigation of new strategies to prevent acute viral respiratory infections(ARI) is essential for reducing the global disease burden. Genetic association studies are valuable in identifying the susceptibility risk factors for diseases, and genetic evidence can expedite drug approval. To date, few studies have been conducted to reveal the susceptibility risks of ARI and identify novel drug targets through multi-omics genetic association analysis. This study aimed to integrate traditional Chinese medicine(TCM) into ARI prevention by identifying novel susceptibility risk loci across multi-ancestry populations and screening potential traditional Chinese medicines targeting these loci. First, with influenza and coronavirus disease 2019(COVID-19) as examples, the data of proteomics, genomics, transcriptomics, DNA methylation, and RNA alternative splicing were integrated to screen the susceptibility risk loci for ARI in European, East Asian, and South Asian populations. The screening was conducted by proteome-wide Mendelian randomization, gene-based association analyses, transcriptome-wide association analyses, and SMR & HEIDI methods. Then, SNPnexus was used to analyze the conservation and biological functions of key susceptibility risk targets for ARI. The druggability of these targets was explored by druggability analysis and phenome-wide association analysis. Potential traditional Chinese medicines targeting the druggable key susceptibility risk loci were screened. RESULTS:: showed that COL15A1 was a key susceptibility risk locus for influenza in European populations. MAN1A2 and RAB1A were identified as key susceptibility risk loci for COVID-19 in East Asian populations, while PPIE, MFGE8, VWA2, FCER2, TREML2, BMP8B, U2AF1L4, and IGFLR1 were identified as key susceptibility risk loci for COVID-19 in South Asian populations. In European populations, ABO was a key susceptibility risk locus for COVID-19. The mutations in these loci were highly deleterious and pathogenic. These loci mainly regulated the signaling pathways in the immune system, interleukin family, and some regulated the coagulation cascade, platelet activation, signaling, and aggregation. COL15A1, MAN1A2, RAB1A, PPIE, MFGE8, VWA2, FCER2, TREML2, BMP8B, and ABO were potential preventive drug targets for ARI. TCM with the effects of replenishing Qi and supplementing essence had the potential of targeting the key susceptibility risk loci. This study presents a new research idea for identifying susceptibility risk loci of ARI and a novel prevention strategy of ARI with TCM.

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