The primary objective of this study is to evaluate the non-inferiority of Coristina® d in the symptomatic treatment of the common cold compared to Resfenol® comparator.

Start Date01 Sep 2016

Sponsor / Collaborator

Brainfarma Indústria Química e Farmacêutica SA

[+2]

NCT02740660

/ CompletedNot ApplicableIIT

Effect on Body Composition With Albuterol and Caffeine Versus Placebo in Adolescents: A Pilot Study

The purpose of this study is to determine whether taking a combination of caffeine and albuterol three times per day will increase muscle and decrease fat in your child's body and to determine how these medications make your child feel. Albuterol is approved by the FDA for the treatment of asthma. It is not approved to increase muscle and decrease body fat in children.

Start Date01 Apr 2016

Sponsor / Collaborator

Pennington Biomedical Research Center

NCT02135965

/ CompletedEarly Phase 1IIT

Testing Potential Synergistic Effects of Albuterol and Caffeine on Metabolic Rate.

The purpose of this study is to define a ratio of Caffeine and albuterol that gives a synergistic increase in metabolic rate.

Start Date01 Apr 2009

Sponsor / Collaborator

Pennington Biomedical Research Center

100 Clinical Results associated with Adenosine receptor x adrenergic receptor

100 Translational Medicine associated with Adenosine receptor x adrenergic receptor

0 Patents (Medical) associated with Adenosine receptor x adrenergic receptor

232

Literatures (Medical) associated with Adenosine receptor x adrenergic receptor

01 Aug 2024·Naunyn-Schmiedeberg's Archives of Pharmacology

Further investigations on the influence of protein phosphatases on the signaling of muscarinic receptors in the atria of mouse hearts

Article

Author: Gergs, Ulrich ; Wackerhagen, Silke ; Fuhrmann, Tobias ; Neumann, Joachim ; Schäfer, Inka

AbstractThe vagal regulation of cardiac function involves acetylcholine (ACh) receptor activation followed by negative chronotropic and negative as well as positive inotropic effects. The resulting signaling pathways may include Gi/o protein-coupled reduction in adenylyl cyclase (AC) activity, direct Gi/o protein-coupled activation of ACh-activated potassium current (IKACh), inhibition of L-type calcium ion channels, and/or the activation of protein phosphatases. Here, we studied the role of the protein phosphatases 1 (PP1) and 2A (PP2A) for muscarinic receptor signaling in isolated atrial preparations of transgenic mice with cardiomyocyte-specific overexpression of either the catalytic subunit of PP2A (PP2A-TG) or the inhibitor-2 (I2) of PP1 (I2-TG) or in double transgenic mice overexpressing both PP2A and I2 (DT). In mouse left atrial preparations, carbachol (CCh), cumulatively applied (1 nM–10 µM), exerted at low concentrations a negative inotropic effect followed by a positive inotropic effect at higher concentrations. This biphasic effect was noted with CCh alone as well as when CCh was added after β-adrenergic pre-stimulation with isoprenaline (1 µM). Whereas the response to stimulation of β-adrenoceptors or adenosine receptors (used as controls) was changed in PP2A-TG, the response to CCh was unaffected in atrial preparations from all transgenic models studied here. Therefore, the present data tentatively indicate that neither PP2A nor PP1, but possibly other protein phosphatases, is involved in the muscarinic receptor-induced inotropic and chronotropic effects in the mouse heart.

01 Jun 2024·Journal of Pharmacy and Pharmacology

Integrating metabolomics and network pharmacology to assess the effects of Mahuang Xixin Fuzi decoction on migraine rats induced by nitroglycerin

Article

Author: Zhang, Yao ; Ge, Fei ; Wang, Chunguo ; Chen, Meng ; Luo, Yamin ; Zhang, Di ; Lu, Yixing ; Meng, Fengxian ; Zhang, Dongmei ; Tao, Xiaohua ; Zhao, Yafang

AbstractObjectivesThis study was designed to investigate the pharmacological activity and therapeutic mechanism of Mahuang Xixin Fuzi decoction (MXFD) on migraine.MethodsMigraine model rats induced by nitroglycerin were established, and then orally administered with MXFD for 7 days. Blood and urine samples were collected to identify differential metabolites with metabolomics. To integrate the findings from network pharmacology and metabolomics analysis, the metabolites and targets related to MXFD therapy for migraine were filtered.Key findingsMXFD was found to alleviate the symptoms of migraines in rats. After treatment with MXFD, nine metabolites were found to be regulated and returned to normal levels. MXFD acted directly on nine key targets including MAOB, MAOA, ADRB1, ADRB2, ADRB3, ADORA2A, ADORA2B, DRD5, and HTR4 and regulated two out of nine metabolites, namely deoxycholic acid and 5-methoxyindoleacetate.ConclusionsThe study found that MXFD can alleviate migraines through multitarget and multicomponent interaction networks.

01 Feb 2024·Immunologic Research

Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system

Article

Author: Halpert, Gilad ; Heidecke, Harald ; Amital, Howard ; Elroy, Tal ; Tsur, Avishai M ; Shoenfeld, Yehuda

We explored a possible association between palpitation manifestation in women with silicone breast implants (SBIs) with circulating level of autoantibodies directed against autonomic nervous system (ANS) receptors. The study was conducted in 93 women with SBIs who arrived to our clinic with diverse symptoms thought to be associated with their implants. Titers of 11 various autoantibodies were measured in the sera of women with SBIs who experienced palpitations (Palpitations, n = 47), did not experience palpitations (Non, n = 46), and healthy women (Control, n = 36). A significant reduction in anti-α2-adrenergic receptor (A2AR, P = 0.035), anti-β2-adrenergic receptor (B2AR, P = 0.027), antimuscarinic receptors M1R (P = 0.048), and anti-M2R (P = 0.039) autoantibodies was found in the 'Palpitations' group as compared with the 'Non' group. Anti-B2AR (P = 0.042), anti-M1R (P = 0.017), and anti-M2R (P = 0.0015) autoantibodies were also significantly reduced in 'Palpitations' as compared with the 'Control' group. Our study shows possible association between autoantibodies directed against ANS receptors, with existing complaints of palpitations in women with SBIs.

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