ARHGAP26

Last update 08 May 2025

Basic Info

Synonyms

ARHGAP26, GRAF, GTPase regulator associated with focal adhesion kinase

+ [7]

Introduction

GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria (PubMed:38081847). Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V (PubMed:27512058). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins.

100 Clinical Results associated with ARHGAP26

100 Translational Medicine associated with ARHGAP26

0 Patents (Medical) associated with ARHGAP26

112

Literatures (Medical) associated with ARHGAP26

01 Jul 2025·European Journal of Pharmacology

Liposome-loaded miR-34c-5p attenuates apoptosis and oxidative stress following hypoxia-ischemia brain damage in neonatal mice by targeting Arhgap26

Article

Author: Xiao, Yilei ; Zhao, Yijing ; Xing, Xiaohui ; Liu, Dexiang ; Liu, Weiyang ; Cheng, Yahong ; Gu, Bing ; Luo, Qian ; Wang, Zhen ; Song, Yan

Neonatal hypoxia-ischemia (HI) brain injury is considered a major cause of neonatal mortality and chronic disease morbidity worldwide. Despite its clinical importance, therapeutic options for HI injury remain limited. Here we demonstrated that miR-34c-5p expression peaks at postnatal day 10 in mice. Meanwhile, the miR-34c-5p levels in the lesioned cortex decreased following HI insult in neonatal mice. miR-34c-5p overexpression confers neuroprotective effects by attenuating brain injury and ROS production. These protective mechanisms were mediated through the inhibition of caspase 3 activation, suppression of microglial activation, and downregulation of pro-inflammatory cytokines in the injured cortex. In contrast, miR-34c-5p downregulation markedly aggravated the infarct area after HI injury. Additionally, miR-34c-5p overexpression improved short-term motor coordination and long-term neurological outcomes, including locomotor activity, learning, and memory functions, which were associated with upregulated synaptic protein expression. Importantly, we developed a non-invasive intranasal delivery system using liposome-encapsulated miR-34c-5p mimics, which significantly ameliorated brain injury at 3 days post-HI. Mechanistic studies revealed that miR-34c-5p directly targets the 3' untranslated region of GTPase activating protein 26 (Arhgap26). In conclusion, we identified a non-invasive method for successfully delivering miR-34c-5p to improve functional recovery after HI insult by targeting Arhgap26.

01 Apr 2025·animal

Genomic insights into selection signatures and candidate genes for milk production traits in buffalo population

Article

Author: Abdel-Shafy, H ; Ma, X Y ; Lu, X R ; Deng, T X ; Duan, A Q

Genetic variability in livestock driven by selection leaves distinct signatures within the genome. However, the comprehensive landscape of the selection responses for milk production traits in the Chinese buffalo population remains elusive. This study employed an integrated haplotype score (iHS) and runs of homozygosity (ROH) analyses of whole-genome sequence data from 100 Chinese buffaloes to decipher selection signatures. Using iHS and ROH, we identified 1 046 and 1 045 significant genomic regions, containing 717 and 263 candidate genes, respectively. The integration of iHS and ROH revealed 258 candidate regions and 108 overlapping genes, representing true selection signatures. Additionally, 94 candidate regions overlapped with 672 previously reported quantitative trait loci associated with key economically important traits. Annotation of the genomic regions highlighted candidate genes linked to milk production traits, including SNORD42, COX18, ANKRD17, ALB, RASSF6, CXCL8, TMEM232, ARHGAP26, and NR3C1. Transcriptome-wide association analysis supported ANKRD17 and CEP41 as potential candidates for affecting milk traits. This study unveils a comprehensive selection signature profile for the Chinese buffalo population by integrating iHS and ROH methods. The findings have broad implications for improving milk production traits in buffalo populations globally, contributing to more sustainable livestock systems. The identified candidate genes shed light on the selection response for milk production traits, offering crucial insights into optimising the breeding strategies for Chinese buffaloes.

01 Mar 2025·Journal of Neuroimmunology

Cerebellar ataxia and depression associated with anti-RhoGTPase-activating protein 26 antibody: A case report

Article

Author: Qian, Min ; Liu, Mange ; Ren, Haitao ; Hongzhi, Guan ; Yang, Yingmai

Neuroimmune disorders associated with anti-RhoGTPase-activating protein 26 immunoglobulin G (IgG) autoantibodies (ARHGAP26; also termed anti-Ca) are infrequent and manifest a significant diversity in clinical presentations, including cerebellar ataxia, psychotic disorders, and cognitive impairments. This case report describes a middle-aged female who developed subacute cerebellar ataxia and depression. Detection of anti-ARHGAP26 IgG in both serum and cerebrospinal fluid (CSF) led to her diagnosis of primary autoimmune cerebellar ataxia, supported by her medical history of Sjögren's syndrome and the identification of CSF-specific oligoclonal bands. After undergoing sequential immunotherapy including corticosteroid, intravenous immunoglobulin, plasma exchange, mycophenolate mofetil and rituximab, her Scale for the Assessment and Rating of Ataxia score improved from 28.5 to 18, demonstrating partial recovery. This case highlights the necessity of considering an autoimmune etiology in patients presenting with subacute cerebellar ataxia and suggests that testing for ARHGAP26-IgG is warranted also when psychocognitive impairment is clinically evident. Early initiation of immunotherapy is important to enhance patient outcomes.

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ARHGAP26

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