CMIP

Last update 08 May 2025

Basic Info

Synonyms

c-Maf inducing protein, C-Maf-inducing protein, c-Mip

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Introduction

Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

100 Clinical Results associated with CMIP

100 Translational Medicine associated with CMIP

0 Patents (Medical) associated with CMIP

Literatures (Medical) associated with CMIP

01 Feb 2025·Clinical and Experimental Dental Research

IgG In Saliva, GCF, and Serum in Young Patients With Grade C Molar Incisor Pattern Periodontitis

Article

Author: Alamri, Meaad M. ; Nibali, Luigi ; Proctor, Gordon

ABSTRACTObjectiveThis cross‐sectional study aimed to investigate immunoglobulin G levels in saliva, gingival crevicular fluid, and serum samples from young patients with grade C molar incisor pattern periodontitis (C/MIP) and age‐matched periodontitis‐free controls.MethodsSaliva, gingival crevicular fluid, and blood samples were collected from 62 patients, divided into 31 cases and 31 periodontitis‐free age‐matched controls. Saliva and blood samples were centrifuged to extract supernatant and serum. Gingival crevicular fluid periopapers were eluted. Human total immunoglobulin G levels were assessed using an Enzyme‐Linked Immunosorbent Assay.ResultsAfter adjusting for covariates, cases had higher Immunoglobulin G levels in saliva (p = 0.005), gingival crevicular fluid (p < 0.001) than controls; however, serum did not reach the significant threshold (p = 0.137). Among other factors contributing to immunoglobulin G levels, males had higher serum immunoglobulin G than females (p = 0.018), and serum immunoglobulin G levels increased with age (p = 0.033). Gender and ethnicity subgroup analyses revealed that C/MIP males had higher saliva IgG (p = 0.018) than control males, and both genders had higher GCF IgG than controls (p ≤ 0.001). C/MIP Caucasians had elevated saliva (p = 0.011) and GCF IgG p = (0.003) compared to the controls, and Asians had higher GCF IgG than the controls (p = 0.011).ConclusionThis study shows for the first time that C/MIP cases have higher Immunoglobulin G levels than controls in saliva and gingival crevicular fluid, confirming its association with C/MIP pathogenesis and suggesting that it could be a potential biomarker in grade C molar incisor pattern periodontitis. Further research on a larger sample size is needed.

01 Jan 2025·Immunology

The Immune Regulatory Functions in B Cells Are Restored by CpG to Reduce Experimental Food Allergy

Article

Author: Liu, Qiao ; Tang, Wang ; Yang, Ping‐Chang ; Xu, Ling‐Zhi ; Peng, Ke‐Ping ; Huang, Jing‐Weng ; Wang, Xiang‐Yu ; Tian, Gui‐Xiang ; Wang, Zhuo‐Ya ; Bin, Dong‐Hua

ABSTRACTDysfunctional immune regulation contributes to the pathogenesis of food allergy (FA). The mechanism behind regulatory B‐cell dysfunction is unclear. CpG has immune regulatory functions. The purpose of this study is to use CpG to recover the immune suppressive functions of B cells in mice with FA. An FA mouse model was created using ovalbumin as the specific antigen. Flow cytometry was used to isolate B cells from the intestinal tissues. The immune regulatory functions of B cells were assessed using immunological approaches. The results showed that the FA response was linked to low IL‐10 levels in gut lavage fluids of FA mice. FA mouse intestinal B cells produced lower amounts of IL‐10 as compared with B cells isolated from naïve control mice. Impaired immune suppressive functions were observed in B cells isolated from the FA mouse intestine. The inducibility of the Il10 expression in naïve B cells of the intestine of FA mice was defective. The induction of Il10 expression in FA B cells could be restored by CpG through regulating the methylation status of the Cmip promoter. CpG promoted the therapeutic efficacy of allergen specific immunotherapy by restoring the induction of IL‐10+ B cells in the intestine. The expression of Il10 in B cells of the FA mouse intestine was impaired. Administration of CpG could restore the expression of Il10 in B cells in the intestine and promote immunotherapy for FA.

01 Dec 2024·Immunologic Research

Impaired inducibility of immune regulatory capacity of peripheral B cells of patients with recurrent pregnancy loss

Article

Author: Ma, Fei ; Liu, Jin ; Feng, Shiyu ; Ning, Yan ; Xu, Lingzhi ; Mo, Lihua ; Wu, Jiaman ; Feng, Xiaoyang ; Li, Jia ; Liu, Yulei ; Yang, Pingchang

The pathogenesis of recurrent pregnancy loss (RPL) is unclear. RPL may have an association with disruption of immune tolerance. The aim of this study is to characterize the inducibility of immune regulatory ability in peripheral naïve B cells of patients with RPL. In this study, blood samples were taken from patients with RPL. B220⁺ B cells were isolated by flow cytometry cell sorting. The gene profile of B cells was analyzed using RNA sequencing (RNAseq). The results showed that peripheral B220⁺ B cells of RPL patients had lower expression of IL10 and exacerbated ER stress. The induction of IL10 expression in peripheral B220⁺ B cells of RPL patients were impaired. High ubiquitination of c-Maf inducing protein (CMIP) was detected in RPL B cells. Exposure to thapsigargin (an ER stress agonist) decreased the amount of CMIP in B cells. The effects of ER stress on reducing CMIP quantity in B cells were mediated by the histone H2B E3 ubiquitin ligase ring finger protein 20 (RNF20). Inhibition of RNF20 or ER stress restored the inducibility of immune regulatory functions of B220⁺ B cells of RPL patients. In summary, peripheral B cells in patients with RPL show impaired immune regulation capacity, in which exacerbated ER stress plays a crucial role. Regulation of ER stress or inhibition of RNF20 can restore the immune regulatory capacity in the B cells.

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