OR52N2

Last update 08 May 2025

Basic Info

Synonyms

Olfactory receptor 52N2, olfactory receptor family 52 subfamily N member 2, Olfactory receptor OR11-57

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Introduction

Odorant receptor.

100 Clinical Results associated with OR52N2

100 Translational Medicine associated with OR52N2

0 Patents (Medical) associated with OR52N2

Literatures (Medical) associated with OR52N2

01 Jun 2023·International Journal of Biological Macromolecules

Olfactory receptor OR52N2 for PGE2 in mediation of guppy courtship behaviors

Article

Author: Lyu, Likang ; Qi, Xin ; Li, Jianshuang ; Wen, Haishen ; Gong, Yu ; Xie, Songyang ; Wang, Xiaojie ; Zuo, Chenpeng ; Li, Yun ; Yan, Shaojing ; Yao, Yijia ; Jing, Xiao

Prostaglandins (PGs) are a type of physiologically active unsaturated fatty acids. As an important sex pheromone, PGs play a vital role in regulating the reproductive behaviors of species by mediating nerve and endocrine responses. In this study, guppy (Poecilia reticulate) was used as the model specie to detect the function of PGE₂ in inducing the onset of courtship behaviors. Our results showed that adding PGE₂ into the water environment could activate the courtship behavior of male guppy, indicating that the peripheral olfactory system mediated the PGE₂ function. Thereafter, the open reading frame (ORF) of olfactory receptor or52n2 was cloned, which was 936 bp in length, coding 311 amino acids. As a typical G protein-coupled receptor, OR52N2 had a conservative seven α-helix transmembrane domains. To confirm the regulatory relationship between OR52N2 and PGE₂, dual-luciferase reporter assay was employed to verify the activation of downstream CREB signaling pathways. Results showed that PGE₂ significantly enhanced CRE promoter activity in or52n2 ORF transient transfected HEK-293 T cells. Finally, localization of or52n2 mRNA were observed in ciliated receptor cells of the olfactory epithelium using in situ hybridization. Our results provide a novel insight into sex pheromone signaling transduction in reproductive behavior.

01 Sep 2021·Journal of Endocrinological InvestigationQ2 · MEDICINE

Potential biomarkers and lncRNA-mRNA regulatory networks in invasive growth hormone-secreting pituitary adenomas

Q2 · MEDICINE

Article

Author: Yang, H ; Zheng, X ; Li, B ; Li, S ; Tang, X ; Yin, H ; Zang, Z ; Shen, R ; He, S

PURPOSEGrowth hormone-secreting pituitary adenomas (GH-PAs) are common subtypes of functional PAs. Invasive GH-PAs play a key role in restricting poor outcomes. The transcriptional changes in GH-PAs were evaluated.METHODSIn this study, the transcriptome analysis of six different GH-PA samples was performed. The functional roles, co-regulatory network, and chromosome location of differentially expressed (DE) genes in invasive GH-PAs were explored.RESULTSBioinformatic analysis revealed 101 DE mRNAs and 70 DE long non-coding RNAs (lncRNAs) between invasive and non-invasive GH-PAs. Functional enrichment analysis showed that epithelial cell differentiation and development pathways were suppressed in invasive GH-PAs, whereas the pathways of olfactory transduction, retinol metabolism, drug metabolism-cytochrome P450, and metabolism of xenobiotics by cytochrome P450 had an active trend. In the protein-protein interaction network, 11 main communities were characterized by cell- adhesion, -motility, and -cycle; transport process; phosphorus and hormone metabolic processes. The SGK1 gene was suggested to play a role in the invasiveness of GH-PAs. Furthermore, the up-regulated genes OR51B6, OR52E4, OR52E8, OR52E6, OR52N2, MAGEA6, MAGEC1, ST8SIA6-AS1, and the down-regulated genes GAD1-AS1 and SPINT1-AS1 were identified in the competing endogenous RNA network. The RT-qPCR results further supported the aberrant expression of those genes. Finally, the enrichment of DE genes in chromosome 11p15 and 12p13 regions were detected.CONCLUSIONOur findings provide a new perspective for studies evaluating the underlying mechanism of invasive GH-PAs.

01 Dec 2016·Nature GeneticsQ1 · BIOLOGY

Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Q1 · BIOLOGY

Article

Author: Franceschi, Silvia ; Macfarlane, Gary J ; Canova, Cristina ; Healy, Claire M ; Eluf-Neto, José ; Thomas, Steve ; Cadoni, Gabriella ; Holcátová, Ivana ; Robinson, Max ; Boffetta, Paolo ; Kjaerheim, Kristina ; Boccia, Stefania ; Olshan, Andrew F ; Steffen, Annika ; Herrero, Rolando ; Ness, Andrew R ; Ahrens, Wolfgang ; Lesseur, Corina ; Znaor, Ariana ; Gaborieau, Valérie ; Mates, Dana ; Shangina, Oxana ; Conway, David I ; Menezes, Ana M ; Tajara, Eloiza H ; Amos, Christopher I ; Diergaarde, Brenda ; Chabrier, Amélie ; Curado, Maria Paula ; de Carvalho, Marcos B ; Brennan, Paul ; Xiao, Xiangjun ; Vilensky, Marta ; Lagiou, Pagona ; Nunes, Fabio D ; Grandis, Jennifer R ; Johansson, Mattias ; Hung, Rayjean J ; Szeszenia-Dąbrowska, Neonila ; McKay, James D ; Peters, Wilbert H M ; Liu, Geoffrey ; Castellsagué, Xavier ; Wünsch-Filho, Victor ; Anantharaman, Devasena ; Lacko, Martin ; Agudo, Antonio ; Polesel, Jerry ; Bueno-de-Mesquita, H Bas ; Zaridze, David ; Fabiánová, Eleonóra ; Richiardi, Lorenzo ; Weissler, Mark C ; Lissowska, Jolanta

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10^-8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10^-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10^-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

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OR52N2

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