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BELFAST, United Kingdom, Dec. 14, 2023 (GLOBE NEWSWIRE) -- CV6 Therapeutics (‘CV6’), a drug development biotechnology company that specializes in innovative small molecule therapeutics for cancer and inflammatory diseases, announces it has received approval from the UK’s medicines regulator, the MHRA, for the company’s first-in-human Phase 1a clinical trial of its lead oncology therapeutic, CV6-168, in patients with colorectal and other cancers. CV6-168 is a first-in-class DNA uracilation agent that selectively targets the enzyme dUTPase. Cancer cell DNA uracilation by CV6-168 is aided by combination with standard cancer therapies including thymidylate synthase (TS) inhibitors such as 5-fluorouracil (5-FU). These CV6-168 drug combinations result in targeted uracil-based DNA damage and cancer cell death while simultaneously stimulating the immune system to further enhance the anticancer effect. DNA uracilation is a novel therapeutic strategy that has demonstrated effectiveness and safety in pre-clinical models with no added toxicity when combined with standard-of-care anti-cancer drugs. The UK multi-centre Phase 1a clinical trial will combine CV6-168 with infusional 5-FU to treat gastrointestinal cancer patients, such as colon, gastric, and pancreatic cancers as well as other tumor types such as melanoma, lung, and ovarian cancers. It will focus on safety, measuring how CV6-168 is absorbed by the body, identifying optimal dosing levels, and gathering initial indications of anti-cancer activity. The initial trial is for up to 50 patients, taking part at leading cancer hospitals in Belfast, Glasgow, Newcastle, and the Royal Marsden in London that are within the UK Experimental Cancer Medicine Centre (ECMC) network. The trial is expected to have dosed its first patient in Q1 2024, with trial read-outs expected in H1 2025. CV6 CEO and Founder Dr Robert Ladner said, “This regulatory approval is a key milestone as we progress CV6-168 into a first-in-human Phase 1a clinical trial. Our innovative oncology therapeutic unlocks the potential of DNA uracilation as a promising new therapeutic approach to cancer treatment, with the opportunity to significantly improve outcomes for patients across multiple cancer types. CV6-168 is a specific, first-in-class dUTPase inhibitor that has a value-driven therapeutic approach, is globally scalable, and can potentially treat many millions of patients annually across multiple high-incidence cancer types.” The Chief Investigator for this trial is Richard Wilson, who is Professor of Gastrointestinal Oncology in the University of Glasgow and specialises in early and late phase cancer clinical trials. He said, “Despite recent advances, there is still huge unmet need for new treatments for colorectal and many other cancers. CV6-168 in combination with 5-FU has the potential to improve on existing treatments, where 5-FU and similar drugs are currently used, in over 8 million people with cancer annually across the world. What sets CV6-168 apart is that the DNA uracilation mechanism selectively damages cancer cell DNA but also triggers signals to the immune system opening up the potential to unleash our natural immunity against the cancer cells. CV6-168 is given by mouth which makes it very easy to combine with other drugs and lessens the burden on patients receiving it. If CV6-168 fulfils its’ promise, then this will give us a new therapeutic option that is easy to take alongside existing standard anti-cancer drugs, and with minimal additional side-effects.” CV6 Therapeutics, originally founded in Los Angeles, is now headquartered in the Patrick G. Johnston Centre for Cancer Research at Queen’s University Belfast. About CV6 Therapeutics CV6 Therapeutics, (NI) Ltd., is a drug development biotechnology company that specializes in value-based, first-in-class, small molecule therapeutics that are scalable to address global unmet medical needs for cancer and inflammatory diseases. Its lead oncology drug candidate CV6-168 has successfully completed all pre-clinical development milestones. The company has UK regulatory approval to start a first-in-human phase 1a clinical trial of CV6-168 in advanced cancers in 2024. The company’s inflammatory disease asset CV6-1271 is in preclinical-development. CV6 has a Grant for R&D from Invest Northern Ireland to support the Phase 1a trial. (1). Investors include QUBIS, the commercialization arm of Queen’s University in Belfast, Invest Northern Ireland, CoFund NI, managed by Clarendon Fund Managers, Techstart Ventures as well as US and UK-based private investors. CV6 Therapeutics, originally founded in Los Angeles, is now headquartered in the Patrick G. Johnston Centre for Cancer Research at Queen’s University Belfast. For more information see our website here and LinkedIn here. References (1) Invest Northern Ireland’s R&D support is part financed by the European Regional Development Fund under the EU Investment for Growth and Jobs Programme 2014–2020. Media Contacts CV6 Therapeutics Dr Robert Ladner, CEO +44 (0) 7500 444287 rladner@cv6t.com Scius Communications Katja Stout +447789435990 katja@sciuscommunications.com Daniel Gooch +447747875479 daniel@sciuscommunications.com

Belfast, UK, 2 November 2022 – CV6 Therapeutics (‘CV6’), a drug development biotechnology company that specializes in innovative small molecule therapeutics for cancer and inflammatory diseases, announces it has secured $9.2m to progress the company’s lead oncology asset CV6-168 into a first-in-human Phase 1a clinical trial and perform further scientific development work. Investors participating in the financing include QUBIS, the commercialization arm of Queen’s University in Belfast, Invest Northern Ireland, CoFund NI, managed by Clarendon Fund Managers, Techstart Ventures as well as US and UK-based private investors. CV6 has also received a Grant for R&D from Invest Northern Ireland* to support the Phase 1a trial. CV6 is developing CV6-168, a novel, first-in-class DNA uracilation agent that selectively targets the enzyme dUTPase. Cancer cell DNA uracilation by CV6-168 is aided by combination with standard cancer therapies such as thymidylate synthase (TS) inhibitors and results in uracil-based DNA damage and cell death while simultaneously stimulating the immune system to further enhance the anticancer effect. DNA uracilation is a novel therapeutic strategy that has demonstrated effectiveness and safety in pre-clinical models with no added toxicity with drug combinations. CV6-168 is set to enter a Phase 1a clinical trial in 2023 that will focus on safety, measuring how the drug is absorbed by the body, identifying optimal dosing levels and gathering initial indications of anti-cancer activity. CV6 CEO and Founder Dr Robert Ladner said, “CV6-168 unlocks the potential of DNA uracilation as a promising new therapeutic approach to cancer treatment, with the opportunity to significantly improve outcomes for patients across multiple cancer types. Securing this financing and a grant for R&D from Invest Northern Ireland will allow us to advance CV6-168 into a first-in-human Phase 1a clinical trial, representing a key milestone for CV6.” CV6 Therapeutics is headquartered in the Patrick G. Johnston Centre for Cancer Research at Queen’s University Belfast. * Invest Northern Ireland’s R&D support is part financed by the European Regional Development Fund under the EU Investment for Growth and Jobs Programme 2014–2020. Notes to Editors About CV6 Therapeutics CV6 Therapeutics, (NI) Ltd., is a drug development biotechnology company that specializes in innovative small molecule therapeutics for cancer and inflammatory diseases. Lead oncology drug candidate CV6-168 has successfully completed all pre-clinical development milestones. The company plans to start a first-in-human phase 1a clinical trial of CV6-168 in advanced cancers in 2023. Inflammatory disease asset CV6-1271 is in preclinical-development. The company was originally founded in 2013 in Los Angeles, California and moved to Northern Ireland to establish the company at Queen’s University in 2015. For more information see our website here and LinkedIn here. Media Contacts CV6 Therapeutics Dr Robert Ladner, CEO +44 (0) 7500 444287 rladner@cv6t.com Scius Communications Katja Stout +447789435990 katja@sciuscommunications.com Daniel Gooch +447747875479 daniel@sciuscommunications.com

NEW YORK, Sept. 03, 2021 (GLOBE NEWSWIRE) -- Scopus BioPharma Inc. (Nasdaq: “SCPS”), a clinical-stage biopharmaceutical company developing transformational therapeutics for serious diseases with significant unmet medical need, today announced that Alan Horsager, Ph.D., President and Chief Executive Officer of Duet Therapeutics, will present at the 14th Annual RNA Consortium Meeting, to be held virtually on Friday, September 10, 2021. Duet Therapeutics is a wholly-owned subsidiary of Scopus. Dr. Horsager is also President — Immuno-Oncology of Scopus. Dr. Horsager’s presentation will be part of the Clinical Translation of Oligonucleotide Therapeutics session. Dr. Horsager will present on Clinical Development of CpG-STAT3 Inhibitors. Duet Therapeutics was recently launched by Scopus BioPharma to integrate the immunotherapy assets of Scopus and Olimmune, creating the Duet Platform. The Duet Platform is comprised of three distinctive complementary CpG-STAT3 inhibitors: • RNA silencing CpG-STAT3siRNA (“DUET-01”) • Antisense CpG-STAT3ASO (“DUET-02”) • DNA-binding inhibitor CpG-STAT3decoy (“DUET-03”) The Duet Platform enables and facilitates development of STAT3 inhibitors which are highly selective for a multitude of different solid tumors and hematological malignancies. Current and potential indications for the Duet Platform include: B-cell non-Hodgkin lymphoma, T-cell non-Hodgkin lymphoma, genitourinary (e.g., prostate, kidney and bladder) and head & neck cancers. Duet’s CpG-STAT3 inhibitors are also being evaluated as combination therapies with checkpoint inhibitors and CAR-Ts. About Scopus BioPharma Scopus BioPharma Inc., both directly and through subsidiaries, is a clinical-stage biopharmaceutical company developing transformational therapeutics for serious diseases with significant unmet medical need. The company’s lead drug candidate is a novel, targeted immuno-oncology RNA therapy for the treatment of multiple cancers. This drug candidate is highly distinctive, encompassing both RNA therapy and immunotherapy by synthetically linking siRNA to an oligonucleotide TLR9 agonist, creating the potential for targeted gene silencing with simultaneous TLR stimulation and immune activation in the tumor microenvironment. Additional STAT3-targeting immunotherapy drug candidates include bi-functional antisense and protein degradation therapies. In addition, the company is developing additional drug candidates that target the endocannabinoid system, including MRI-1867 for the treatment systemic sclerosis. The company also seeks to identify additional compelling technologies for potential acquisition, in-licensing and/or other similar transactions. Receive updates by following Scopus BioPharma on Twitter here. Forward-Looking Statements This press release may include forward-looking statements that involve risks and uncertainties. Forward-looking statements are statements that are not historical facts. Such forward-looking statements are subject to risks (including those set forth in the company’s Form 10-K for the fiscal year ended December 31, 2020, as amended, filed with the U.S. Securities and Exchange Commission (“SEC”)) and uncertainties which could cause actual results to differ from the forward-looking statements. The company expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in the company’s expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based. Investors should realize that if our underlying assumptions for the projections contained herein prove inaccurate or that known or unknown risks or uncertainties materialize, actual results could vary materially from our expectations and projections. Further, there can be no assurance that the company will identify and/or consummate any transaction relating to any additional technologies. Contacts Rodd Leeds/David Waldman Crescendo Communications, LLC Tel: (212) 671-1020 Email: SCPS@crescendo-ir.com Hugh Burns/Delia Cannan/Nicholas Leasure Reevemark Tel: (212) 433-4600 Email: scopus@reevemark.com