MEF2B

Last update 08 May 2025

Basic Info

Synonyms

MEF2B, myocyte enhancer factor 2B, Myocyte-specific enhancer factor 2B

+ [3]

Introduction

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

100 Clinical Results associated with MEF2B

100 Translational Medicine associated with MEF2B

0 Patents (Medical) associated with MEF2B

147

Literatures (Medical) associated with MEF2B

01 Dec 2025·Journal of Hematopathology

A rare case of primary testicular follicular lymphoma in a pediatric patient

Article

Author: Peterson, Jess F ; King, Rebecca L ; Rahimi, Nina ; Nguyen, Amanda J ; Viswanatha, David S ; Artymiuk, Cody J ; McPhail, Ellen D

Testicular follicular lymphoma (TFL) is an exceedingly rare lymphoma that typically occurs in young male patients and is now recognized as a distinct diagnostic entity in the International Consensus Classification. TFL shows some clinicopathologic and genetic overlap with pediatric-type follicular lymphoma (PTFL). We report a case of TFL occurring in an otherwise healthy 4-year-old boy who presented with painless scrotal swelling. Orchiectomy revealed a 1.5-cm left testicular mass. Histologic sections showed a dense lymphoid infiltrate with nodular/follicular architecture growing between the seminiferous tubules. The infiltrate was composed of CD20/PAX5-positive B-cells that coexpressed germinal center markers (CD10, BCL6, MEF2B); they were negative for BCL2. No BCL2 or BCL6 rearrangements and no TNFRSF14 deletion were detected by FISH. Chromosomal microarray analysis detected copy-neutral loss of heterozygosity (CN-LOH) at 1p36.33-p36.32 (region of TNFRSF14). Next-generation sequencing detected variants in GNA13, RHOA, and TNFRSF14. In conclusion, this case shows the classic clinical, pathologic, and genetic features of TFL and highlights the similarities to PTFL and the importance of distinguishing this entity from other subtypes of FL. Patients with TFL typically respond favorably to orchiectomy and chemotherapy and have excellent clinical outcomes.

01 Feb 2025·Immunity, Inflammation and Disease

Construction of the Single‐Cell Landscape of Hashimoto's Thyroiditis Tissue and Peripheral Blood by Single‐Cell RNA Sequencing

Article

Author: Mou, Yakui ; Yao, Wenjie ; Wang, Yuantao ; Wang, Xiaojie ; Tang, Yuxiao ; Song, Kaiyu ; Song, Xicheng ; Zhang, Qinling ; Zhou, Jin

ABSTRACTBackgroundHashimoto's thyroiditis (HT) is the most common organ‐specific autoimmune disease, and its etiology may be related to genetic, environmental, and epigenetic factors. However, its exact pathogenesis remains elusive.MethodsIn this study, single‐cell transcriptomic sequencing and bioinformatics analysis were performed on the thyroid tissues of six HT patients, peripheral blood mononuclear cells (PBMCs) of four HT patients, and normal thyroid tissue of one healthy control. A panoramic single‐cell atlas of HT was constructed to explore changes in the abundance of different cell subsets in the states of the disease.ResultsA single‐cell atlas of HT was constructed, and eight cell types were defined based on the marker genes. Subsequent clustering analysis of T cells, B cells, myeloid, and thyroid follicular cells revealed that the abundance rates of the CD8+T_CCL4L2, B_MEF2B_BCL6, Mac_APOE, Mac_IL1B, and TFC_PAX8_NKX2‐1 subgroups were elevated in thyroid tissues of HT patients. However, the abundance rate of the NKT_KLRD1_KLRC2 subgroup was risen in the PBMCs of HT patients. Ig‐producing plasma cells were specifically enriched in the B‐cell subgroup.ConclusionThe present study further validated the role of immune cells in the pathogenesis of HT at the cellular level. In addition, a new cell subset B_MEF2B_BCL6 was found. It could be speculated that MEF2B mainly transactivates the expression level of the transcriptional repressor BCL6, leading to the development of HT. A new cell subset TFC_PAX8_NKX2‐1 was also identified, in which the specific transcription factors PAX8 and NKX2‐1 were highly expressed in HT tissues.

21 Dec 2024·Cureus

Adult-Onset Pediatric-Type Follicular Lymphoma of the Parotid Gland

Article

Author: Bin Harmal Al Shamsi, Humaid O ; Faruk Abbu, Rahil U ; Ebaied, Tamer ; Albaldawy, Mazin J ; Nadaf, Ashraf

Pediatric-type follicular lymphoma (PTFL) is an extremely rare B-cell lymphoma that primarily affects children and young adults, typically in individuals under 25 years old, with a median age of 15 years. Here, we report a rare case of PTFL in a 27-year-old adult male who presented with a slow-growing mass near his left ear. Initial CT scans of the neck revealed two oval-shaped, smooth, well-defined, homogeneously enhancing soft tissue density lesions in the superficial lobe of the left parotid gland. A complete surgical excision was performed, and a postoperative ultrasound of the neck confirmed complete removal, with only hypoechoic changes observed in the parotid gland. Comprehensive immunohistochemical analysis showed CD20-positive B cells co-expressing germinal center markers CD10 and BCL6 but negative for BCL2 and cyclin D1. The Ki-67 proliferation index was notably elevated, indicating high cellular activity. Additional findings included MEF2B positivity, confirming the lymphoma diagnosis, and an immunoglobulin gene rearrangement, which demonstrated a monoclonal B-cell population consistent with a neoplastic process. CD21 staining further revealed distorted follicular dendritic cell networks and attenuated IgD-positive mantle. Fluorescence in situ hybridization (FISH) analysis showed no rearrangements in BCL2, IRF4, or BCL6, and any deletion in the 1p36 region (TNFRSF14 gene), ruling out other lymphoma types. Histologically, the nodules showed distorted secondary follicles with obscured germinal centers, confirming PTFL. At the three-month follow-up, the patient demonstrated satisfactory healing with no signs of recurrence. This case underscores the importance for oncologists to perform a thorough differential diagnosis of head and neck masses, as PTFL can present with characteristics similar to classical follicular lymphoma, IRF4-rearranged large B-cell lymphoma, pediatric nodal marginal zone lymphoma, and reactive follicular hyperplasia. A comprehensive diagnostic approach, including clinical, pathological, and immunohistochemical analyses, is essential for developing an accurate diagnosis and management plan for PTFL, especially in atypical adult presentations.

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MEF2B

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