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Last update 08 May 2025

NPFF

Last update 08 May 2025

Basic Info

Synonyms

FMRFAL, FMRFamide-related peptides, Neuropeptide AF

+ [7]

Introduction

Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.

Drugs associated with NPFF

DN-9

Target

NPFF x κ opioid receptor x μ opioid receptor

Mechanism

NPFF agonists [+2]

Active Org.

Lanzhou University

Originator Org.

Lanzhou University

Active Indication

Inflammation [+1]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with NPFF

100 Translational Medicine associated with NPFF

0 Patents (Medical) associated with NPFF

436

Literatures (Medical) associated with NPFF

01 Jun 2025·General and Comparative Endocrinology

In vivo effects of NPFF and NPAF peptides on gene expression in the brain-pituitary–gonadal axis of female half-smooth tongue soles

Article

Author: Li, Ruixue ; Liu, Hanlin ; Chen, Huapu ; Wang, Bin ; Yu, Zhihua

Neuropeptide FF (NPFF) is one of the members of RF-amide peptide family, which has been implicated in diverse physiological processes across mammals. However, there is scarce information regarding the biological function of NPFF in fish reproduction. In the current study, npff was identified and characterized in the half-smooth tongue sole. The NPFF precursor consisted of one signal peptide and two mature peptides, designated as NPFF and NPAF. Analysis of tissue distribution indicated that npff exhibited high expression levels in the brain and pituitary, while its mRNA levels were much lower in other peripheral tissues. Subsequently, the possible function of NPFF and NPAF on the brain-pituitary-gonad reproductive axis was studied in this species by intraperitoneal injection. At the brain level, both NPFF and NPAF had an inhibitory influence on the levels of transcripts corresponding to kiss1, kiss1r, kiss2, gnrh3, spx1, pnx, gpr173a, and gpr173b. NPFF reduced gnrh2 mRNA levels, but promoted gnihr expression. Moreover, NPAF down-regulated gnih and tac3 expression. At the pituitary levels, gh, gthα, and fshβ mRNA levels were suppressed by NPFF and NPAF, whereas lhβ mRNA levels were elevated. In the ovary, these two peptides stimulated expression of star, p450c17, and fshr. Likewise, NPFF increased 17β-hsd and lhr mRNA levels, and NPAF stimulated p450arom transcript levels. However, 3β-hsd was inhibited by NPFF. Overall, our results suggest that NPFF and NPAF may play distinct roles in control of reproduction of half-smooth tongue sole at multiple levels of the brain-pituitary-ovarian axis.

24 Mar 2025·Bioscience, Biotechnology, and Biochemistry

FRPR-1, a G protein-coupled receptor in the FMRFamide-related peptide receptor family, modulates larval development as a receptor candidate of the FMRFamide-like peptide FLP-1 in Caenorhabditis elegans

Article

Author: Une, Risako ; Shiraishi, Akira ; Bito, Tomohiro ; Iwasaki, Takashi ; Maega, Sho ; Kawano, Tsuyoshi ; Ono, Masahiro ; Uegaki, Riko ; Satake, Honoo

AbstractFMRFamide-like peptides (FLPs) and their receptors, FMRFamide-related peptide receptors (FRPRs) are widely conserved in free-living and parasitic nematodes. Herein, we identified FRPR-1 as an FLP-1 receptor candidate involved in larval development and diapause in the model nematode Caenorhabditis elegans. Our molecular genetic study, supported by in silico research, revealed the following: (1) frpr-1 loss-of-function completely suppresses the promotion of larval diapause caused by flp-1 overexpression; (2) AlphaFold2 analysis revealed the binding of FLP-1 to FRPR-1; (3) FRPR-1 as well as FLP-1 modulates the production and secretion of the predominant insulin-like peptide DAF-28, which is produced in ASI neurons; and (4) the suppression of larval diapause by frpr-1 loss-of-function is completely suppressed by a daf-28 defect. Thus, FRPR-1 regulates larval development and diapause by modulating DAF-28 production and secretion. This study may provide new insights into the development of novel nematicides targeting parasitic nematodes using FRPR-1 inhibitors.

01 Mar 2025·Journal of Psychopharmacology

A single injection of neuropeptide QRFP in the lateral hypothalamus decreased food intake

Article

Author: Vörös, Dávid ; Lénárd, László ; Szábó, Ádám ; Berta, Beáta ; Dusa, Daniella ; Ollmann, Tamás ; László, Kristóf ; Péczely, László ; Zagorácz, Olga ; Kovács, Anita ; Kertes, Erika ; Kállai, Veronika

Background and aim: Severe eating disorders, such as obesity, bulimia, and anorexia, keep increasing to epidemic proportions worldwide. Understanding of neuropeptides’ role in complex hunger/satiety mechanisms may allow new prospects for treatment and prevention. Pyroglutamylated arginine-phenylalanine-amide peptides (QRFPs) are thought to enhance feeding following the central administration. Methods: In our study, QRFP-26 was delivered into the lateral hypothalamic area of male Wistar rats by direct microinjections, as QRFP-26 expressing neurons and binding sights are densely present in this neural structure. The consumption of liquid food was measured over 60-min. Results: Both doses (100 and 200 ng) significantly decreased food intake compared to the control treatment. Neuropeptide Y Y1R/NPFF (neuropeptide FF) antagonist BIBP3226 eliminated the anorexigenic effect caused by QRFP-26 administration. QRFP-26 affects neither general locomotion, behavioral patterns examined in the Open Field Test, nor anxiety. Conclusion: This study is the first to report the anorexigenic action of QRFP-26 following direct administration into the hypothalamus, emphasizing steady locomotion and anxiety levels. We have shown that the effect of QRFP can be linked to the neuropeptide Y (NPY) Y1 or NPFF receptors.

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