TRIM47

Last update 08 May 2025

Basic Info

Synonyms

E3 ubiquitin-protein ligase TRIM47, Gene overexpressed in astrocytoma protein, GOA

+ [5]

Introduction

E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.

100 Clinical Results associated with TRIM47

100 Translational Medicine associated with TRIM47

0 Patents (Medical) associated with TRIM47

Literatures (Medical) associated with TRIM47

01 Feb 2025·Cancer Science

TRIM47 promotes hypopharyngeal and laryngeal cancers progression through promoting K63‐linked ubiquitination of vimentin

Article

Author: Lei, Dapeng ; Li, Zinan ; Chang, Fen ; Sun, Xiangkai ; Wang, Yin ; Qin, Shichao

AbstractHypopharyngeal and laryngeal cancers which belong to head and neck squamous cell carcinoma (HNSCC) are the two most malignant types of head and neck cancer, characterized by a low 5‐year survival rate, high recurrence and metastasis rate. It is vital to explore strategies to suppress metastasis and improve prognosis for patients with these cancers. In this research, we analyzed the clinical data and found that E3 ubiquitin ligase TRIM47 was upregulated in cancer tissues of hypopharyngeal cancer and was closely associated with poor survival outcomes. In terms of mechanism, we performed tandem affinity chromatography and denatured Ni‐NTA Agarose pulldown. As a result, TRIM47 was found to interact with vimentin and control vimentin stabilization through ubiquitination, specifically in the form of K63 chains. Importantly, through experiments of cancer cell viability and migration, we found that TRIM47 could enhance the proliferation and metastasis abilities of cancer cells in a vimentin‐dependent manner, thus promoting the advancement of hypopharyngeal and laryngeal cancers. TRIM47 was verified to regulate cancer cells metastasis in vivo using metastasis models. All these results imply that TRIM47 emerges as a potential biomarker for early diagnosis and metastasis prediction of hypopharyngeal and laryngeal cancers and represents a promising therapeutic target.

01 Feb 2025·Pathology - Research and Practice

Whole genome and transcriptome analysis of pancreatic acinar cell carcinoma elucidates mechanisms of homologous recombination deficiency and unravels novel relevant fusion events

Article

Author: Deshpande, Aditya ; Delgado-de la Mora, Jesús ; Sigouros, Michael ; Halima, Ahmed ; Lieberman, Michael D ; Hadi, Kevin ; Manohar, Jyothi ; Ocean, Allyson J ; Mosquera, Juan Miguel ; Popa, Elizabeta C ; Al Assaad, Majd ; Medina-Martínez, Juan S ; Karaaslan, Selda ; Sboner, Andrea ; Elemento, Olivier ; Hissong, Erika ; Jessurun, José

Pancreatic acinar cell carcinoma (PACC) is a rare pancreatic tumor with a heterogeneous clinical course and, except for radical surgery, limited treatment options. We present a comprehensive study encompassing whole-genome and RNA sequencing of 7 tumor samples from 3 metastatic PACC patients to further delineate its genomic landscape and potential therapeutic implications. Our findings reveal distinct signatures of homologous recombination deficiency (HRD) in patients harboring pathogenic germline BRCA1/2 and FANCL mutations, demonstrating favorable responses to poly (ADP-ribose) polymerase 1 (PARP) inhibitors with prolonged disease-free intervals. Additionally, we first describe structural variants in PACC, including BRCA1::TRIM47 fusion and another variant impacting FANCC, both events related to HRD, and we also identify alterations in the mitogen-activated protein kinase (MAPK) pathway, including RAF1 duplication as well as novel BRAF::SORBS2 and MAP7D2::SND1 gene fusions, offering potential targets for therapy. Our study underscores the importance of genome and transcriptome-wide profiling of PACC, to help guide personalized treatment strategies to improve patient outcomes.

01 Jan 2025·iScience

TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination

Article

Author: Zhang, Chen ; Zhang, Cai ; Han, Jingjie ; Li, Jinying ; Yu, Changyun ; Zhang, Qianqian

Tripartite motif-containing 47 (TRIM47) is a member of the TRIM family, which has E3 ligase activity and has been demonstrated to be involved in tumor development. In this work, we found that TRIM47 is highly expressed in head and neck squamous cell carcinomas (HNSCC) tissues. TRIM47 overexpression promoted HNSCC cell proliferation. Downregulation of TRIM47 suppressed HNSCC cell proliferation and promoted apoptosis and autophagy. TRIM47 suppression caused cell proliferation inhibition and apoptosis promotion could be reversed by 3-MA, an autophagy inhibitor. In mechanism, TRIM47 interacted with XIAP-associated factor 1 (XAF1), promoting its ubiquitination and degradation. XAF1 promoted HNSCC cell apoptosis and autophagy. TRIM47 overexpression caused cell proliferation promotion and autophagy inhibition could be reversed by XAF1 overexpression. Animal experiments confirmed that the knockdown of TRIM47 inhibits tumor growth in vivo. Ultimately, TRIM47 promotes the ubiquitination and degradation of XAF1 and suppresses apoptosis and autophagy to promote the progression of HNSCC.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

TRIM47

Basic Info

Related

Analysis