CDC42EP4

Last update 08 May 2025

Basic Info

Synonyms

Binder of Rho GTPases 4, BORG4, CDC42 effector protein 4

+ [5]

Introduction

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

100 Clinical Results associated with CDC42EP4

100 Translational Medicine associated with CDC42EP4

0 Patents (Medical) associated with CDC42EP4

Literatures (Medical) associated with CDC42EP4

01 Jun 2024·Journal of Medical Virology

Value of a secretomic approach for distinguishing patients with COVID‐19 viral pneumonia among patients with respiratory distress admitted to intensive care unit

Article

Author: Blangy‐Letheule, Angélique ; Dupas, Thomas ; Lecomte, Jules ; Rozec, Bertrand ; De Waard, Michel ; Montnach, Jérôme ; Bourgoin‐Voillard, Sandrine ; Roquilly, Antoine ; Persello, Antoine ; Seve, Michel ; Habert, Damien ; Denis, Manon ; Vergnaud, Amandine ; Leroux, Aurélia A. ; Oulehri, Walid ; Courty, José ; Lauzier, Benjamin ; Hassoun, Dorian

AbstractIn intensive care units, COVID‐19 viral pneumonia patients (VPP) present symptoms similar to those of other patients with Nonviral infection (NV‐ICU). To better manage VPP, it is therefore interesting to better understand the molecular pathophysiology of viral pneumonia and to search for biomarkers that may clarify the diagnosis. The secretome being a set of proteins secreted by cells in response to stimuli represents an opportunity to discover new biomarkers. The objective of this study is to identify the secretomic signatures of VPP with those of NV‐ICU. Plasma samples and clinical data from NV‐ICU (n = 104), VPP (n = 30) or healthy donors (HD, n = 20) were collected at Nantes Hospital (France) upon admission. Samples were enriched for the low‐abundant proteins and analyzed using nontarget mass spectrometry. Specifically deregulated proteins (DEP) in VPP versus NV‐ICU were selected. Combinations of 2 to 4 DEPs were established. The differences in secretome profiles of the VPP and NV‐ICU groups were highlighted. Forty‐one DEPs were specifically identified in VPP compared to NV‐ICU. We describe five of the best combinations of 3 proteins (complement component C9, Ficolin‐3, Galectin‐3‐binding protein, Fibrinogen alpha, gamma and beta chain, Proteoglycan 4, Coagulation factor IX and Cdc42 effector protein 4) that show a characteristic receptor function curve with an area under the curve of 95.0%. This study identifies five combinations of candidate biomarkers in VPP compared to NV‐ICU that may help distinguish the underlying causal molecular alterations.

01 Jan 2023·Diabetes, metabolic syndrome and obesity : targets and therapy

Analysis of Methylome, Transcriptome, and Lipid Metabolites to Understand the Molecular Abnormalities in Polycystic Ovary Syndrome.

Article

Author: Zhang, Fei ; Wang, Zhijiang ; He, Mengju ; Kang, Yani ; Zhang, Bohan ; Lu, Chunbo ; Ding, Yicen

PurposeThis study aimed to identify differentially methylated genes (DMGs) and differentially expressed genes (DEGs) to investigate new biomarkers for the diagnosis and treatment of polycystic ovary syndrome (PCOS).MethodsTo explore the potential biomarkers of PCOS diagnosis and treatment, we performed methyl-binding domain sequencing (MBD-seq) and RNA sequencing (RNA-seq) on ovarian granulosa cells (GCs) from PCOS patients and healthy controls. MBD-seq was also performed on the ovarian tissue of constructed prenatally androgenized (PNA) mice. Differential methylation and expression analysis were implemented to identify DMGs and DEGs, respectively. The identified gene was further verified by real-time quantitative PCR (RT-qPCR) and methylation-specific PCR (MSP) in clinical samples. Furthermore, ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) was carried out on PCOS patients and healthy controls to identify differential lipid metabolites.ResultsCompared to the control group, 13,526 DMGs related to the promoter region and 2429 DEGs were found. The function analysis of DMGs and DEGs showed that they were mainly enriched in glycerophospholipid, ovarian steroidogenesis, and other lipid metabolic pathways. Moreover, 5753 genes in DMGs related to the promoter region were screened in the constructed PNA mice. Integrating the DMGs data from PCOS patients and PNA mice, we identified the following 8 genes: CDC42EP4, ERMN, EZR, PIK3R1, ARHGEF18, NECTIN2, TSC2, and TACSTD2. RT-qPCR and MSP verification results showed that the methylation and expression of TACSTD2 were consistent with sequencing data. Additionally, 15 differential lipid metabolites were shown in the serum of PCOS patients. The differential lipids were involved in glycerophospholipid and glycerolipid metabolism.ConclusionUsing integration of methylome and lipid metabolites profiling we identified 8 potential epigenetic markers and 15 potential lipid metabolite markers for PCOS. Our results suggest that aberrant DNA methylation and lipid metabolite disorders may provide novel insights into the diagnosis and etiology of PCOS.

06 Dec 2021·EMBO reportsQ1 · BIOLOGY

Cdc42‐Borg4‐Septin7 axis regulates HSC polarity and function

Q1 · BIOLOGY

Article

Author: Soller, Karin ; Zheng, Yi ; Geiger, Hartmut ; Eiwen, Karina ; Menon, Manoj B ; Gaestel, Matthias ; Florian, Maria Carolina ; Sakk, Vadim ; Grigoryan, Ani ; Schuster, Tanja ; Kandi, Ravinder ; Senger, Katharina

Aging of hematopoietic stem cells (HSCs) is caused by the elevated activity of the small RhoGTPase Cdc42 and an apolar distribution of proteins. Mechanisms by which Cdc42 activity controls polarity of HSCs are not known. Binder of RhoGTPases proteins (Borgs) are known effector proteins of Cdc42 that are able to regulate the cytoskeletal Septin network. Here, we show that Cdc42 interacts with Borg4, which in turn interacts with Septin7 to regulate the polar distribution of Cdc42, Borg4, and Septin7 within HSCs. Genetic deletion of either Borg4 or Septin7 results in a reduced frequency of HSCs polar for Cdc42 or Borg4 or Septin7, a reduced engraftment potential and decreased lymphoid-primed multipotent progenitor (LMPP) frequency in the bone marrow. Taken together, our data identify a Cdc42-Borg4-Septin7 axis essential for the maintenance of polarity within HSCs and for HSC function and provide a rationale for further investigating the role of Borgs and Septins in the regulation of compartmentalization within stem cells.

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CDC42EP4

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