Last update 01 Nov 2024

MMP11

Last update 01 Nov 2024

Basic Info

Synonyms

matrix metallopeptidase 11, matrix metalloproteinase 11 (stromelysin 3), Matrix metalloproteinase-11

+ [7]

Introduction

May play an important role in the progression of epithelial malignancies.

Drugs associated with MMP11

TK-002(Takis)

Target

MMP11

Mechanism

MMP11 inhibitors

Active Org.

Takis

Originator Org.

Takis

Active Indication

Colonic Cancer [+2]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with MMP11

100 Translational Medicine associated with MMP11

0 Patents (Medical) associated with MMP11

1,719

Literatures (Medical) associated with MMP11

01 Feb 2025·Parasitology International

A pilot study of intestinal protist detection in humans, animals, and the environment in a slum area in Mymensingh, Bangladesh

Article

Author: Hossain, Md. Zawad ; Gentekaki, Eleni ; Amin, A R M Beni ; Tsaousis, Anastasios D ; Hossain, Md Zawad ; Amin, A.R.M. Beni ; Tsaousis, Anastasios D. ; Maxamhud, Sadiya ; Shahiduzzaman, Md

The purpose of this study was to investigate the presence and transmission of Cryptosporidium spp., Blastocystis sp., Giardia intestinalis and Entamoeba histolytica between different hosts and their shared environment in a slum area of Bangladesh. A total of 102 samples were collected from Mymensingh, Bangladesh. This collection encompassed 16 human samples, 35 soil samples and 51 animal samples from various households within the region. The detection of Cryptosporidium spp., Blastocystis sp., G. intestinalis, and E. histolytica was carried out using nested PCR and/or quantitative PCR methodologies. Among the samples, 24 human, animal, and soil out of 102 were found positive for Blastocystis sp., spanning seven subtypes: ST2, ST3, ST7, ST10, ST23, ST24 and ST25. Additionally, eight samples (8/102) including human, animal and soil tested positive for Cryptosporidium spp., including C. parvum, C. baileyi, C. bovis, and C. meleagridis. Furthermore, one soil sample tested positive for G. intestinalis assemblage B, while no samples tested positive for E. histolytica. The detection of Cryptosporidium spp., Blastocystis sp., and G. intestinalis in this study has provided insights into their presence, extending beyond humans. Moreover, these findings highlight the importance of embracing a One Health perspective with an emphasis on specific parasitic microorganisms.

01 Dec 2024·Molecular Biology Reports

Macrophages regulate healing-associated fibroblasts in diabetic wound

Article

Author: Wang, Jiancheng ; Xiao, Yu ; Luo, Zhijun ; Deng, Xiaohui ; Qian, Jieqi ; Zhang, Huifeng ; Zhu, Lingyan

AbstractBackgroundRecovery from a foot ulcer is compromised in a diabetic status, due to the impaired tissue microenvironment that consists of altered inflammation, angiogenesis and fibrosis. Phenotypic alterations in both macrophages and fibroblasts have been detected in the diabetic wound. Recently, a fibroblast subpopulation that expresses high matrix metalloproteinase 1 (MMP1), MMP3, MMP11 and Chitinase-3-Like Protein 1 (CHI3L1) was associated with a successful diabetic wound healing. However, it is not known whether these healing-associated fibroblasts are regulated by macrophages.Methods and ResultsWe used bioinformatic tools to analyze selected public databases on normal and diabetic skin from patients, and identified genes significantly altered in diabetes. In a mouse model for diabetic wound healing, we detected not only a loss of the spatiotemporal changes in interleukin 1β (IL1β), IL6, IL10 and vascular endothelial growth factor A (VEGF-A) in wound macrophages, but also a compromised expression of MMP1, MMP3, MMP11, CHI3L1 and VEGF-A in healing-associated wound fibroblasts in a diabetic status. Co-culture with diabetic macrophages significantly reduced the expression of MMP1, MMP3, MMP11, CHI3L1 and VEGF-A in fibroblasts from non-diabetic wound. Co-culture with non-diabetic macrophages or diabetic macrophages supplied with IL6 significantly increased the expression of MMP1, MMP3, MMP11, CHI3L1 and VEGF-A in fibroblasts from diabetic wound. Moreover, macrophage-specific expression of IL6 significantly improved wound healing and angiogenesis in diabetic mice.ConclusionsMacrophages may induce the activation of wound-healing-associated fibroblasts, while the defective macrophages in diabetes may be corrected with IL6 treatment as a promising therapy for diabetic foot disease.

01 Nov 2024·Microbial Pathogenesis

Blastocystis species growth inhibition in vitro by plant extracts

Article

Author: Mokhtar, Amira Bakr ; Gad, Samer Eid Mohamed ; Karanis, Panagiotis ; Ahmed, Shahira Abdelaziz Ali ; Gad, Samer Eid Mohammed ; Schou, Chad

BACKGROUNDThe protist Blastocystis species (sp.) inhabits the gastrointestinal tracts of humans and animals. In recent decades, alternative natural products derived from plants have demonstrated potential as effective treatments for Blastocystis infection. The anti-Blastocystis activity of three herbal ethanolic extracts- Odontites linkii subsp. cyprius, Ptilostemon chamaepeuce subsp. cyprius and Quercus alnifolia-were investigated in this study.METHODSThree distinct isolates of Blastocystis sp. maintained in vitro were molecularly subtyped. Cytotoxicity analysis was performed on individual Blastocystis sp. isolates using 250, 500, 1000, and 2000 μg/mL herbal ethanolic extracts for 24 and 48 hours. Quantitative, morphological, and size alterations of Blastocystis cells assessed the cytotoxicity of herbal anti-Blastocystis effect.RESULTSFollowing subtyping analysis, one strain of Blastocystis had ST3 and ST1 mixed subtypes, and two strains had ST1 subtypes. Starting after 24 h of incubation, P. cham. subsp. cyprius (1000 μg/mL) exhibited the most pronounced and consistent anti-Blastocystis cytotoxicity against all three strains, comparable to metronidazole. The Ptilostemon chamaepeuce subsp. cyprius anti-Blastocystis cytotoxicity was evident in parasite quantitative distress, morphological alterations, and significant reductions in cell size. Odontites linkii subsp. cyprius cytotoxicity varied among the three Blastocystis strains. The three Blastocystis strains were resistant to Quercus alnifolia.CONCLUSIONP. cham. subsp. cyprius was a potent and promising new herbal extract against Blastocystis sp. in vitro assays.

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MMP11

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