SLC25A16

Last update 08 May 2025

Basic Info

Synonyms

D10S105E, GDA, GDC

+ [8]

Introduction

May be involved in the transport of coenzyme A in the mitochondrial matrix (PubMed:11158296). Very little is known about the physiological function of this carrier (PubMed:11158296).

100 Clinical Results associated with SLC25A16

100 Translational Medicine associated with SLC25A16

0 Patents (Medical) associated with SLC25A16

137

Literatures (Medical) associated with SLC25A16

31 Dec 2025·Renal Failure

Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy

Article

Author: Zhang, Jiaai ; Liu, Yang ; Zhou, Junan ; Zhou, Zhelun ; Wu, Rong ; Wang, Xiaoyi

Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Mitochondrial dysfunction in the kidney caused by diabetes has previously been linked to the pathogenesis of DN. By mass spectrometry, we identified characteristic proteins of DN from the renal mitochondria in mouse model. To identify the core proteins among them, Mendelian randomization (MR) analysis, microarray data validation, and drug-target interaction analysis were employed. MR analysis found that 189 candidate targets had a causal link with DN risk factors (estimated glomerular filtration rate (eGFR), urinary albumin excretion, and serum creatinine). After systematic analysis, we validated that SLC25A16, CTNND1, C2CD2L, ALDH3A2, NEU1, APEH, CORO1A, NUDT19, and NDUFA4L2 are the core proteins with promising druggability in DN. This study suggests the feasibility of using MR analysis for DN drug target screening, and provides potential insights into mitochondrial dysfunction research, which may contribute to further DN pathogenesis exploration.

13 Mar 2025·Annals of Botany

Evolutionary diversification of C2 photosynthesis in the grass genus Homolepis (Arthropogoninae)

Article

Author: de Castro Arruda, Iago Augusto ; Lage Viana, Pedro ; Della Torre, Felipe ; Weake, Samantha ; Alvarenga, Joyce Pereira ; Sage, Rowan F ; Patel, Ria ; Stata, Matt ; Cheng, Shifeng ; Liu, Hongbing ; Watanabe, Emile J ; Delfino Barbosa, João Paulo Rodrigues Alves ; Sage, Tammy L ; Ludwig, Martha ; das Chagas Mendonca, Ane Marcela

AbstractBackground and AimsTo better understand C4 evolution in monocots, we characterized C3–C4 intermediate phenotypes in the grass genus Homolepis (subtribe Arthropogoninae).MethodsCarbon isotope ratio (δ13C), leaf gas exchange, mesophyll (M) and bundle sheath (BS) tissue characteristics, organelle size and numbers in M and BS tissue, and tissue distribution of the P-subunit of glycine decarboxylase (GLDP) were determined for five Homolepis species and the C4 grass Mesosetum loliiforme from a phylogenetic sister clade. We generated a transcriptome-based phylogeny for Homolepis and Mesosetum species to interpret physiological and anatomical patterns in an evolutionary context, and to test for hybridization.Key ResultsHomolepis contains two C3 species (H. glutinosa, H. villaricensis), one species with a weaker form of C2 termed sub-C2 (H. isocalycia), and two C2 species (H. longispicula, H. aturensis). Homolepis longispicula and H. aturensis express over 85 % of leaf glycine in centripetal mitochondria within the BS, and have increased fractions of leaf chloroplasts, mitochondria and peroxisomes within the BS relative to H. glutinosa. Analysis of leaf gas exchange, cell ultrastructure and transcript expression show M. loliiforme is a C4 plant of the NADP-malic enzyme subtype. Homolepis comprises two sister clades, one containing H. glutinosa and H. villaricensis and the second H. longispicula and H. aturensis. Homolepis isocalycia is of hybrid origin, its parents being H. aturensis and a common ancestor of the C3 Homolepis clade and H. longispicula.ConclusionsPhotosynthetic activation of BS tissue in the sub-C2 and C2 species of Homolepis is similar to patterns observed in C3–C4 intermediate eudicots, indicating common evolutionary pathways from C3 to C4 photosynthesis in these disparate clades. Hybridization can diversify the C3–C4 intermediate character state and should be considered in reconstructing putative ancestral states using phylogenetic analyses.

01 Mar 2025·Physiologia Plantarum

Improved photorespiration has a major impact on the root metabolome of Arabidopsis

Article

Author: Florian, Alexandra ; Jahnke, Kathrin ; Fernie, Alisdair R. ; Bauwe, Hermann ; Hagemann, Martin ; Timm, Stefan ; Alseekh, Saleh

AbstractPhotorespiration is an essential metabolic repair process in oxygenic photosynthesis, as it detoxifies Rubisco's inhibitory oxygenase byproduct, 2‐phosphoglycolate (2‐PG). It has been demonstrated that improving endogenous photorespiration in C3 plants through enzyme overexpression can enhance photosynthesis and promote plant growth. However, the potential impact of improved photorespiration in leaves on heterotrophic roots remained unexplored. To address this, we conducted a metabolome analysis of Arabidopsis leaves and roots using transgenic lines with enhanced glycine decarboxylase (GDC) activity, achieved by overexpressing the mitochondrial lipoamide dehydrogenase (mtLPD1) subunit. In the leaves, mtLPD1 overexpression primarily resulted in reduced steady‐state levels of intermediates associated with photorespiration, the tricarboxylic acid (TCA) cycle, and soluble sugars, while intermediates related to nitrogen metabolism were elevated. In roots, where mtLPD1 expression was unchanged, we observed contrasting accumulation patterns in the transgenic lines compared to the wildtype, including increased levels of photorespiratory and TCA‐cycle intermediates. Notably, we also detected elevated amounts of soluble sugars, nitrate, and starch. Phloem exudate analysis revealed altered metabolite profiles in the overexpressors, particularly with respect to photorespiratory intermediates linked to the GDC reaction, as well as soluble sugars and metabolites involved in cellular redox homeostasis. This suggested an increased transport of these metabolites from shoots to roots, thereby altering sink organ metabolism. In summary, we hypothesize that optimizing photorespiration enhances photosynthesis, which leads to an increased export of carbon surplus to heterotrophic tissues. Thus, improving photorespiration may hold potential for increasing yields in beet‐ and tuber‐forming plants.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

SLC25A16

Basic Info

Related

Analysis