TRIM31

Last update 08 May 2025

Basic Info

Synonyms

C6orf13, E3 ubiquitin-protein ligase TRIM31, HCG1

+ [6]

Introduction

E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:18773414, PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (By similarity).

100 Clinical Results associated with TRIM31

100 Translational Medicine associated with TRIM31

0 Patents (Medical) associated with TRIM31

282

Literatures (Medical) associated with TRIM31

01 Jun 2025·Environmental Research

Autotrophic Uranium (VI) bioreduction in groundwater by siderite: Comparison with sulfur and zero-valent iron

Article

Author: Zhang, Yidan ; Ren, Meng ; Zhu, Yuling ; Wang, Wenzhong ; Xia, Chuanjin

Uranium (U), recognized as a significant health risk in groundwater, has become a key focus in environmental remediation efforts. While numerous electron donors have been investigated for the removal of U(VI) through microbial processes, the potential of abundant and economical Fe(II)-containing minerals remains unexplored. Here, a new inorganic electron donor, siderite (FeCO₃) was proposed. Although siderite demonstrates a lesser electron-donating capacity than Fe(0) and S(0), the Siderite-B bioreactor successfully enriched microbes belonging to the Azotobacter genus, which are known for their nitrogen-fixing ability. Within this system, Azotobacter facilitated the oxidation of Fe(II) coupled with the reduction of U(VI). Initially, Fe(II) donated electrons to the NAD⁺/NADH couple. Subsequently, NADH transferred these electrons to the Rnf/Fix complex, which in turn donated them to ferredoxin, catalyzing the reduction of U(VI) to U(IV). The Siderite-B autotrophic bioreactor achieved a U(VI) removal efficiency of 93.40 ± 0.47 % over 144 h, which was slightly lower than the S(0)-B bioreactor (97.12 ± 0.50 %) and the Fe(0)-B bioreactor (95.58 ± 0.95 %). In contrast, S(0)-B and Fe(0)-B bioreactors were enriched with microbes belonging to the Thiobacillus genus, which reduced U(VI) mainly through Fe-S oxidoreductase and Cytochrome C mediated electron transfer. Over a 90-day continuous-flow experiment, the Siderite-B bioreactor exhibited high U(VI) removal efficiencies of 96.83 ± 1.12 %, 95.92 ± 1.84 %, and 85.28 ± 1.41 % at influent U(VI) concentrations of 10, 20, and 30 mg/L, respectively. The findings highlight the potential of siderite as an effective and autotrophic electron donor for U(VI) reduction, offering a cost-effective and environmentally friendly alternative for groundwater uranium remediation.

01 May 2025·International Immunopharmacology

Therapeutic potential of quercitrin in intervertebral disc degeneration: Targeting pyroptosis and inflammation

Article

Author: Wu, Xinyu ; Yu, Minyang ; Li, Ze ; Chen, Yiyu ; Jiang, Chao ; Gong, Yuhang ; Tang, Fang ; Wang, Zhangfu ; Yao, Can ; Hong, Zhenghua ; Bao, Yuxuan ; Fang, Zhiyu ; Pan, Qiaohong

BACKGROUNDIntervertebral disc degeneration (IDD) is the predominant cause of low back pain (LBP), that leads to significant disability and imposes a substantial socioeconomic burden. Despite its prevalence, effective treatment for IDD has yet to be fully established. This study aimed to explore the therapeutic potential of quercitrin (QUE) in IDD development and to elucidate its underlying mechanisms.METHODSIn vitro, we investigated the effects of QUE on ECM metabolism, inflammatory response and pyroptosis in IL-1β-stimulated nucleus pulposus cells (NPCs), along with the potential mechanisms. In vivo, mice lumbar spinal instability (LSI) was established to determined the impact of QUE on IDD progression.RESULTSQUE significantly alleviated inflammation and maintained the ECM homeostasis under IL-1β stimulation in NPCs. Moreover, QUE appeared to inhibit pyroptosis, which was closely related to intense inflammatory response. Notably, the protective effects of QUE were abrogated upon inhibition of TRIM31 activity, indicating that TRIM31 mediated pyroptosis suppression is crucial for the therapeutic effects of QUE.CONCLUSIONQUE plays an important role in alleviating pyroptosis and inflammation within NPCs, thereby slowing the progression of IDD. Therefore, QUE might emerge as a promising therapeutic candidate for IDD, holding the potential for clinical application in the future.

16 Apr 2025·International Journal of Systematic and Evolutionary Microbiology

Isolation and characterization of Sporomusa carbonis sp. nov.: a carboxydotrophic hydrogenogen in the genus of Sporomusa isolated from a charcoal-burning pile

Article

Author: Poehlein, Anja ; Müller, Volker ; Rosenbaum, Florian P. ; Daniel, Rolf ; Eysell, Lena ; Böer, Tim

A Gram-negative bacterial strain, designated ACPtT, was isolated from the top of the covering soil of an active charcoal-burning pile. The cells of ACPtT were strictly anaerobic, rod-shaped and grew optimally at 40 °C and pH 7. The substrates ribose, glucose, sucrose, raffinose, melezitose, pyruvate, vanillate, syringate, methanol and CO were utilized for growth. Phylogenomic analysis of the 4.1 Mb genome showed that strain ACPtT represented a novel species of the genus Sporomusa. The most closely related species to ACPtT was Sporomusa malonica, with an average amino acid identity of 80.1%. The genome of ACPtT encoded cytochromes, ubiquinones, the Wood–Ljungdahl gene cluster and an Rnf complex, which were identified as common features of all Sporomusa type strains. However, strain ACPtT did not ferment H2+CO2 via acetogenesis as other Sporomusa species but employed the metabolism of a carboxydotrophic hydrogenogen, converting CO to H2+CO2. Based on the genomic, morphological and physiological features presented in this study, strain ACPtT is proposed as a novel species in the genus Sporomusa, with the name Sporomusa carbonis sp. nov. (DSM 116159T and CCOS 2105T).

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TRIM31

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