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Last update 23 Jan 2025

ITPR

Last update 23 Jan 2025

Basic Info

Synonyms

Inositol triphosphate receptors, InsP3R

Introduction-

Drugs associated with ITPR

INNOVA-102

Target

ITPR3

Mechanism

ITPR3 antagonists

Active Org.-

Originator Org.

Innovatis Pharma Corp

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with ITPR

100 Translational Medicine associated with ITPR

0 Patents (Medical) associated with ITPR

5,105

Literatures (Medical) associated with ITPR

01 Mar 2025·Genes & Diseases

Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation

Article

Author: Yang, Guoyin ; He, Xinyi ; Xin, Liangjing ; Zheng, Leilei ; Zhu, Ye ; Song, Jinlin ; Tan, Hao ; Meng, Xuehuan ; Zhai, Qiming ; Li, Xiang

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas heavy forces decelerate it. However, the mechanisms by which PDLCs sense biomechanical stimuli and affect osteoclastic activities under different mechanical forces (MFs) remain unclear. This study demonstrates that mechanosensitive ion channel Piezo1-mediated Ca²⁺ signal conversion is crucial for sensing and delivering biomechanical signals in PDLCs under heavy-force conditions. Heavy MF up-regulated Piezo1 in PDLCs, reducing mitochondrial Ca²⁺ influx by inhibiting ITPR3 expression in mitochondria-associated membranes. Decreased mitochondrial calcium uptake led to reduced cytoplasmic release of mitochondrial DNA and inhibited the activation of the cGAS‒STING signaling cascade, subsequently inhibiting monocyte-to-osteoclast differentiation. Inhibition of Piezo1 or up-regulation of STING expression under heavy MF conditions significantly increased osteoclast activity and accelerated OTM. These findings suggest that heavy MF-induced Piezo1 expression in PDLCs is closely related to the control of osteoclast activity during OTM and plays an essential role in alveolar bone remodeling. This mechanism may be a potential therapeutic target for accelerating OTM.

01 Mar 2025·Comparative Biochemistry and Physiology Part D: Genomics and Proteomics

Effect of food enrichment based on diverse feeding regimes on the immunity of Nibea albiflora by biochemical and RNA-seq analysis of the spleen

Article

Author: Wang, Jiaxing ; Zhang, Xiumei ; Zheng, Yuting ; Xu, Dongdong ; Xu, Anle ; Sun, Jipeng

Nibea albiflora is an economically valuable aquaculture species but suffers from various diseases caused by bacteria and parasites. It is necessary to investigate some novel methods to improve the immunity. In this study, three feeding regimes (A: commercial diet; B: 90 % commercial diet+10 % ice-fresh Exopalaemon carinicauda); C: 90 % commercial diet+5 % ice-fresh Exopalaemon carinicauda + 5 % live Perinereis nuntia, named Control group, Group 1 and Group 2 with similar nutrient and energy content were designed to construct the food enrichment model to investigate their effects on the immunity of this species. The study was focused on spleen tissue where biochemical and RNA-seq analysis were performed to reach our goals. The results showed that fish fed the enriched food showed higher immunity than the Control group fish. Food enrichment feeding also could enhance fish adaptive capacity which contributes to enhancing immunity. Compared to the Control group, the diet B feeding enhanced the fish immunity and adaptive capacity by up-regulating important genes like BAX, ITPR3, NOS1, NLRP3 and down-regulating the gene GOT1. Similarly for the diet C feeding, it improved not only fish immunity but also the neurotransmission activity associated with a good physiological condition by up regulating the genes ADCY5, CACNA1C, SMAD4, NOS1 and RXRB. The diet C feeding was the best in improving fish immunity. Above all, our study revealed the positive effects of such a food enrichment model on the fish and provided evidences and data which support the application of the feeding strategies in the healthy culturing of the fish.

01 Mar 2025·Neuropsychopharmacology Reports

Dysregulated HPA axis during postnatal developmental stages in the BTBRT⁺ Itpr3^tf/J mouse: A model of autism spectrum disorder

Article

Author: Nozu, Hitoshi ; Mannari‐Sasagawa, Takayo ; Nishi, Mayumi ; Goto, Sayaka ; Endo, Nozomi ; Horii‐Hayashi, Noriko ; Hiraishi, Atsuo ; Makinodan, Manabu ; Okuda, Mamiko ; Kitsuki, Michiko

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder. Some children with ASD show enhanced cortisol response to stress. BTBR T+Itpr3tf/J (BTBR) mice, an ASD model, display behavior consistent with the three diagnostic categories of ASD and exhibit an exaggerated response to stress in adulthood. However, it remains unclear how basal corticosterone levels change and how the hypothalamic–pituitary–adrenal axis responds to stress during the early life stages in BTBR mice. In this study, we found that basal corticosterone levels showed characteristic changes, peaking at weaning during postnatal development in both BTBR and control C57BL/6J (B6J) mice. Furthermore, we observed higher corticosterone and corticotropin‐releasing hormone levels in BTBR mice than in B6J mice following acute stress exposure during weaning; however, adrenocorticotropic hormone levels were lower in BTBR mice. Glucocorticoid receptor mRNA expression levels in the hippocampus and lateral septum after stress were higher in BTBR mice than in B6J mice. This study documented changes in corticosterone levels at baseline during postnatal development in mice and showed that BTBR mice exhibited disrupted stress responses at weaning.

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