PTPRK

Last update 08 May 2025

Basic Info

Synonyms

protein tyrosine phosphatase receptor type K, Protein-tyrosine phosphatase kappa, PTPK

+ [3]

Introduction

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.

100 Clinical Results associated with PTPRK

100 Translational Medicine associated with PTPRK

0 Patents (Medical) associated with PTPRK

118

Literatures (Medical) associated with PTPRK

01 Apr 2025·The Journal of the Acoustical Society of America

Whole genome sequencing identifies genetic candidates for high-frequency hearing loss in canaries (serinus canaria)

Article

Author: Madison, Farrah N. ; Conte, Matthew A. ; Brown, Jane A. ; Dooling, Robert J. ; Carleton, Karen L.

Over hundreds of years, breeders have selectively bred different strains of canaries for plumage and song characteristics. One strain, the Belgian Waterslager canary, has been bred for loud, low frequency song and coincidently has been found to have a high-frequency hearing loss due to damaged and missing hair cells in the basilar papilla. Here, we investigated the possible genetic basis for this hearing loss in the Belgian Waterslager canary by conducting whole-genome Illumina (San Diego, CA) sequencing in three canary strains. We identified a total of 16 Belgian Waterslager male-specific “high-impact” single nucleotide polymorphisms (SNP) variants with three mutations occurring within genes previously identified in mammalian hair cell abnormalities and hearing loss disorders: pericentriolar material 1 (PCM1), p21 (RAC1) activated kinase 3 (PAK3)-like, and protein tyrosine phosphatase receptor type K (PTPRK). Interestingly, we also identified three male-specific “high-impact” SNP variants in one of our control strains: the American Singer canary. One of these mutations occurs within genes previously associated with hearing loss in mammals. Since songbirds rely on hearing to develop a normal vocal repertoire, investigating the role of these genes in hearing loss at the molecular level may provide a valuable animal model for examining the relationship between hearing loss and vocal development in humans.

01 Feb 2025·FEBS Open Bio

Potential radiosensitive germline biomarkers in the testes of wild mice after the Fukushima accident

Article

Author: Shimizu, Yoshinaka ; Nakayama, Ryo ; Anderson, Donovan ; Goto, Jun ; Shibata, Jin ; Nakata, Akifumi ; Shinoda, Hisashi ; Satoh, Takashi ; Tokita, Syun ; Yamashiro, Hideaki ; Fujishima, Yohei ; Kinoshita, Yoh ; Goh, Valerie Swee Ting ; Palmerini, Maria Grazia ; Miura, Tomisato ; Fukumoto, Manabu ; Ikema, Hikari ; Uemura, Ippei ; Hatha, Abdulla Mohamed

We investigated potential germline‐specific radiosensitive biomarkers in the testes of large Japanese field mice (Apodemus speciosus) exposed to low‐dose‐rate (LDR) radiation after the Fukushima accident. Fukushima wild mice testes were analysed via RNA‐sequencing to identify genes differentially expressed in the breeding and non‐breeding seasons when compared to controls. Results revealed significant changes during the breeding season, with Lsp1 showing a considerable upregulation, while Ptprk and Tspear exhibited significant reductions. Conversely, in the non‐breeding season, Fmo2 and Fmo2 (highly similar) were significantly upregulated in radiation‐exposed Fukushima mice. qPCR analysis results were consistent with transcriptome sequencing, detecting Lsp1 and Ptprk regulation in the testes of Fukushima mice. While differences in gene expression were observed, these do not imply any causal association between the identified biomarkers and chronic LDR exposure, as other factors such as the environment and developmental age may contribute. This study provides valuable insights into the reproductive biology is affected by environmental radiation and highlights the value of assessing the effects of chronic LDR radiation exposure on testicular health in wild mice.

12 Dec 2024·Blood

Flavell JR, Baumforth KRN, Wood VHJ, et al. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus–encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood. 2008;111(1):292-301.

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PTPRK

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