SH3BGRL2

Last update 08 May 2025

Basic Info

Synonyms

FASH3, Fovea-associated SH3 domain-binding protein, SH3 domain binding glutamate rich protein like 2

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Introduction-

100 Clinical Results associated with SH3BGRL2

100 Translational Medicine associated with SH3BGRL2

0 Patents (Medical) associated with SH3BGRL2

Literatures (Medical) associated with SH3BGRL2

01 Apr 2023·CellQ1 · BIOLOGY

Structural basis of membrane skeleton organization in red blood cells

Q1 · BIOLOGY

Article

Author: Li, Ningning ; He, Meng-Ting ; Zhang, Qiangfeng Cliff ; Dong, Meng-Qiu ; Chen, Siyi ; Xu, Kui ; Gao, Ning

The spectrin-based membrane skeleton is a ubiquitous membrane-associated two-dimensional cytoskeleton underneath the lipid membrane of metazoan cells. Mutations of skeleton proteins impair the mechanical strength and functions of the membrane, leading to several different types of human diseases. Here, we report the cryo-EM structures of the native spectrin-actin junctional complex (from porcine erythrocytes), which is a specialized short F-actin acting as the central organizational unit of the membrane skeleton. While an α-/β-adducin hetero-tetramer binds to the barbed end of F-actin as a flexible cap, tropomodulin and SH3BGRL2 together create an absolute cap at the pointed end. The junctional complex is strengthened by ring-like structures of dematin in the middle actin layers and by patterned periodic interactions with tropomyosin over its entire length. This work serves as a structural framework for understanding the assembly and dynamics of membrane skeleton and offers insights into mechanisms of various ubiquitous F-actin-binding factors in other F-actin systems.

01 Feb 2022·Journal of Clinical Laboratory AnalysisQ4 · MEDICINE

A panel of three serum microRNA can be used as potential diagnostic biomarkers for nasopharyngeal carcinoma

Q4 · MEDICINE

ArticleOA

Author: Zhou, Yaqi ; Liu, Kaihao ; Yang, Weiqiang ; Huang, Guocheng ; Chen, Xuan ; Lu, Chong ; Li, Xinji ; Zhong, Jiatao ; Li, Rongkang ; Lai, Yongqing ; Hu, Hongyi ; Peng, Xiqi ; Zhang, Chunduo

AbstractBackgroundNasopharyngeal carcinoma is cancer with unique epidemiological characteristics, showing obvious ethnicity, gender, and geographical prevalence. More and more evidence shows that microRNAs are stable in serum and are specific to different tumor types. Therefore, miRNA is a new non‐invasive biomarker for cancer detection.MethodsThe experiment is divided into three stages, namely, the screening stage, the training stage, and the verification stage. We took 54 patients with nasopharyngeal carcinoma and 108 healthy controls as the research objects. We use the receiver‐operating characteristic (ROC) curve and area under the ROC curve (AUC) to evaluate the diagnostic value of miRNA. Finally, a three‐miRNA panel with high diagnostic efficiency was constructed. In addition, we conducted biological information analysis of these miRNAs to explore their functions.ResultsIn NPC patients, the expression of five serum miRNAs (miR‐29c‐3p, miR‐143‐5p, miR‐150‐5p, miR‐145‐3p, and miR‐205‐5p) is significantly dysregulated. Among them, the diagnostic value of these three miRNAs (miR‐29c‐3p, AUC = 0.702; miR‐143‐5p, AUC = 0.733; and miR‐205‐5p, AUC = 787) is more prominent. The diagnostic panel constructed by them has a higher diagnostic value (AUC = 0.902). Through the analysis of the TCGA data set, the target gene of the three‐miRNA panel may be KLF7, NRG1, SH3BGRL2, and SYNPO2.ConclusionThe three‐miRNA panel (miR‐29c‐3p, miR‐143‐5p, and miR‐205‐5p) may become a novel non‐invasive biological marker for nasopharyngeal cancer screening.

01 Apr 2021·Biochemical and Biophysical Research CommunicationsQ3 · BIOLOGY

SH3BGRL2 functions as a crucial tumor suppressor in glioblastoma tumorigenesis

Q3 · BIOLOGY

Article

Author: Wang, Chenyang ; Wei, Zhimin ; Cai, Shan ; Bian, Li ; Nie, Zhi ; Li, Yanxi ; Wang, Chunyan

Glioblastoma is the most common and severe primary intrinsic tumor of the central nervous system. Glioblastoma harbors glioma stem cells (GSCs) as it not only possesses self-renewal and differentiation properties but also accounts for significant chemotherapy resistance and recurrence. Thus, targeting GSCs may be essential in overcoming the resistance and recurrence thereby improving GBM treatment. However, the underlying mechanism to sustain GSCs remains largely unknown. Here, we report that SH3 domain binding glutamate-rich protein like 2 (SH3BGRL2) is weakly expressed in glioblastoma multiforme (GBM) and isocitrate dehydrogenase1 (IDH1) wildtype GBM and correlated with glioma patients' poor prognosis. Moreover, ectopic expression of SH3BGRL2 significantly inhibited GBM cell growth, migration, and GSCs self-renewal in vitro as well as tumor growth in vivo. Additionally, we found that SH3BGRL2 suppressed SOX2 and CD133 expression, which are key regulators involved in GSCs self-renewal. Collectively, our findings shed additional light on SH3BGRL2 has potential to serve as a biomarker and a potent therapeutic target for patients with glioma.

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SH3BGRL2

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