HMGN4

Last update 08 May 2025

Basic Info

Synonyms

high mobility group nucleosomal binding domain 4, High mobility group nucleosome-binding domain-containing protein 4, HMG17L3

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Introduction-

100 Clinical Results associated with HMGN4

100 Translational Medicine associated with HMGN4

0 Patents (Medical) associated with HMGN4

190

Literatures (Medical) associated with HMGN4

01 Apr 2025·Journal of Cellular and Molecular Medicine

IRX5 Promoted SREBP1‐Mediated de Novo Fatty Acid Synthesis via HMGN4 in Hepatocellular Carcinoma

Article

Author: Zhang, Yiqiong ; Li, Chengcheng ; Li, Xing ; Xu, Yongjie ; Pan, Wei ; Huang, Changyudong ; Zhu, Liying ; Zeng, Zhu

ABSTRACTHepatocellular carcinoma (HCC), a prevalent malignant tumour, ranks highly in both morbidity and mortality, and its prevention and treatment need further studies. The transcription factor iroquois homeobox 5 (IRX5) plays an essential role in HCC, whereas little is known about its exact functions and underlying mechanisms in tumour metabolism reprogramming. Besides, as a transcription factor that mainly locates in nuclei, IRX5 lacks a nuclear localisation sequence, which makes uncovering the mechanism of IRX5 translocating into the nuclei of great significance. Here, we first found that both IRX5 and HCC development are highly expressed; IRX5 accelerates de novo fatty acid synthesis and promotes cancer cell proliferation and progression. Moreover, the GST pull‐down combined with GC/MS experiments identified an interaction between IRX5 and high‐mobility group nucleosomal binding domain 4 (HMGN4). Immunofluorescence analysis showed that IRX5 and HMGN4 colocalised within the nucleus. Coimmunoprecipitation further confirmed their direct interaction. The elevated expression of HMGN4 enhanced the nuclear transport of IRX5. Taken together, our observations suggest that HMGN4 driving IRX5 nuclear translocation promotes HCC development via de novo fatty acid synthesis reprogramming.

14 Mar 2025·Organic Letters

Access to Chiral Dihydro-1,4-Benzoxazine-2-Carboxylates through NHC-Catalyzed Dynamic Kinetic Resolution

Article

Author: Wei, Guanbin ; Liu, Bin ; Wang, Jianta ; Liu, Qinqin ; Zhang, Tianyuan ; Yang, Chao ; Liao, Weike ; Huang, Jiayu ; He, Qing ; Tang, Lei ; Wang, Rong-Hua ; Yang, Zaihui ; Kong, Xiangkai

A chiral carbene-catalyzed dynamic kinetic resolution for the facile synthesis of enantioenriched dihydro-1,4-benzoxazine-2-carboxylates is disclosed. The reaction conditions are mild, and a diversity of substituents are well-tolerated in this transformation. In addition, our methodology also provides an efficient strategy for building chiral chromane-2-carboxylate and 2,3-dihydro-1,4-benzodioxane-2-carboxylate. The optically pure products generated from this protocol can be easily derived as the key intermediates of chiral drugs and bioactive molecules.

24 Feb 2025·JACS Au

N-Heterocyclic-Carbene-Catalyzed Imine Umpolung for the Cross-Coupling of Quinoxalin-2-ones with Isatins

Article

Author: Kunhiraman, Anusree A. ; Das, Rohan Chandra ; Biju, Akkattu T. ; Barik, Shilpa

The N-heterocyclic carbene (NHC)-catalyzed umpolung of aldimines using quinoxalin-2-ones for intermolecular reactions is demonstrated. Specifically, NHC-catalyzed cross-coupling of quinoxalin-2-ones with isatins proceeds via the generation of aza-Breslow intermediates by the addition of carbene to the C=N moiety of quinoxalinones followed by interception with isatins to afford diverse oxindoles in moderate to good yields and good functional group compatibility. Moreover, detailed mechanistic studies involving the isolation and characterization of the imidoyl azoliums (oxidized form of the aza-Breslow intermediates) are provided. Considering the significance of scaffolds bearing both quinoxalin-2-one and oxindole moieties in medicine and natural products, the synthesized molecules employing the NHC-catalyzed imine umpolung strategy are likely to find promising applications.

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HMGN4

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