RNF112

Last update 08 May 2025

Basic Info

Synonyms

BFP, Brain finger protein, ring finger protein 112

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Introduction

E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).

100 Clinical Results associated with RNF112

100 Translational Medicine associated with RNF112

0 Patents (Medical) associated with RNF112

372

Literatures (Medical) associated with RNF112

15 Apr 2025·Proceedings of the National Academy of Sciences

Structural and functional characterization of the brain-specific dynamin superfamily member RNF112

Article

Author: Tian, Ruijun ; Yang, Bingke ; Shi, Lijun ; Bian, Xin ; Gao, Song ; Huang, Li-Li ; Li, Kangning ; Yuan, Yuerong ; Zhang, Haiqing ; Ye, Xueting ; Zhong, Ya-Ting ; Meng, Yang ; Ma, Menghan ; Yu, Bing ; Wang, Yunyun ; Pan, Runfeng ; Zhong, Hao-Ran

Most members of the dynamin superfamily of large guanosine triphophatases (GTPases) have an ability to remodel membranes in response to guanosine triphosphate (GTP) hydrolysis. Ring Finger Protein 112 (RNF112) (ZNF179/neurolastin) is a recently identified brain-specific dynamin-like protein possessing a really interesting new gene (RING) finger domain. Despite its essential role as an E3 ligase in neuron development, the architecture of RNF112 and the exact role of its GTPase activity remain unknown. Here, we determined the crystal structure of truncated RNF112 (RNF112 T ) containing a GTPase domain (GD) and three-helical middle domain (MD) at different nucleotide-loading states. In the nucleotide-free (apo) state, the monomeric RNF112 T remained in a unique self-restraint conformation characterized by docking of the proximal end of the MD to a groove in the GD. At the transition state of GTP hydrolysis, the MD was released from the GD and stretched aside to form an intertwined RNF112 T homodimer. Engineered RNF112 equipped with the C-terminal elements of ATL1 or the two transmembrane domains of yeast Sac1p relocated to the endoplasmic reticulum and was capable of mediating membrane remodeling. Taken together, our results offer necessary understandings of RNF112 as a dynamin-like large GTPase in its cellular function and provide insights into the functional mechanisms of dynamin superfamily proteins.

01 Apr 2025·Intensive and Critical Care Nursing

Obesity paradox of sepsis in long-term outcome: The differential effect of body composition

Article

Author: So, Min Wook ; Kim, Ha Lim ; Park, Jong Myung ; Cho, Woo Hyun ; Kim, Dohyung ; Yeo, Hye Ju

BACKGROUNDThe obesity paradox has been widely studied recently; however, its impact on the long-term prognosis of sepsis and the protective mechanism of body mass have not yet been sufficiently revealed.METHODSWe retrospectively evaluated the association between obesity and 1-year survival after sepsis in a single university-affiliated hospital and examined the differential effects of muscle mass and adiposity.RESULTSAdult patients with sepsis or septic shock (n = 1492)were classified into obese (n = 300) and nonobese (n = 1192) groups. One-year mortality due to sepsis was lower in the obese than in the nonobese (52.0 % vs. 64.8 %; p < 0.001). In multivariate Cox analysis, one-year mortality due to sepsis was independently associated with body mass index (BMI) (hazard ratio 0.96). In the subgroup analysis, 705 were divided into four groups according to the psoas muscle index (PMI) and body fat percentage (BFP) to assess the differential impact of body fat and muscle mass on the one-year outcome of sepsis. One-year mortality was significantly different among the four groups (high BFP/low PMI, 60.6 %; high BFP/high PMI, 42.1 %; low BFP/high PMI, 34.8 %; low BFP/low PMI, 63.2 %; p = 0.002). The adjusted hazards ratio of one-year mortality of sepsis, which was normalized to the low BFP/high PMI group, were 1.2 (p = 0.585), 2.2 (p = 0.016), and 2.3 (p = 0.009) in groups of high BFP/high PMI, high BFP/low PMI, and low BFP/low PMI, respectively.CONCLUSIONAn obesity paradox has been observed in the long-term outcomes of patients with sepsis, and muscle mass may be more critical than fat mass as a protective mechanism against obesity.IMPLICATIONS FOR CLINICAL PRACTICEA high BMI is linked to a more favorable long-term prognosis in sepsis, with muscle mass playing a more critical role than fat mass. A proactive nutritional and conditioning program may benefit patients anticipating major procedures and potential ICU admission. Such preparation could enhance their resilience and improve outcomes when facing critical illness, including sepsis.

01 Apr 2025·Journal of Hazardous Materials

Dose-dependent toxic effects of triclosan on Rana omeimontis larvae: Insights into potential implications for neurodegenerative diseases

Article

Author: Jiang, Jianping ; Yuan, Chunling ; Xia, Xuemei ; Wei, Siru ; Duan, Yu ; Cai, Yanmei ; Xie, Jiahui ; Wang, Shouhong ; Cao, Yixin ; Chen, Guiying ; Liu, Jiongyu ; Yu, Guihua

The widespread use of antimicrobial agent triclosan (TCS) poses significant health risks to both aquatic organisms and humans. The research on its neurotoxicity and underlying mechanisms is, however, limited. Here we first conducted a 32-day exposure experiment with five TCS concentrations (10, 30, 60, 90 and 120 µg/L) to investigate its impact on overall gene expression in Rana omeimontis larvae. Transcriptomics analysis unveiled a strong dose-dependent pattern of gene expression alterations, with a distinct transcriptomic shift observed in the T030 (30 µg/L) group. In addition, neurodegenerative disease pathway and oxidative stress response GO (gene ontology) terms were found to be highly enriched across the regulated genes in all TCS-exposed groups, suggesting potential TCS-induced neurotoxicity. To further explore this, we performed a 40-day experiment with a low (30 µg/L) or high (90 µg/L) TCS concentration. Morphological assessments revealed that TCS-exposed larvae exhibited developmental and growth inhibition. Using RT-qPCR and immunohistochemical analysis, we confirmed that TCS exposure induced neurotoxicity and triggered neurodegenerative diseases as suggested by Tau protein aggregation in the midbrain. Consistent with these findings, TCS-exposed larvae displayed abnormal behaviors. Our study thus for the first time presents a comprehensive assessment of the adverse effects of TCS exposure on amphibian larvae, encompassing morphological, biochemical, and physiological aspects. Notably, we identified RNF112 and Tau as potential molecular targets that may mediate TCS-induced neurotoxicity. These findings advance the knowledge on how organisms respond to environmental changes and highlight the importance of further investigation into the potential neurotoxicity of TCS within aquatic ecosystems and its implications for human health.

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RNF112

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