Last update 21 Mar 2024

MEK2

Dual specificity mitogen-activated protein kinase kinase 2

Basic Info

Synonyms
MAP激酶激酶2, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2
+ [9]
Introduction
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).

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