Last update 01 Nov 2024

CACNA1G-AS1

Last update 01 Nov 2024

Basic Info

Synonyms

CACNA1G antisense RNA 1, CACNA1G-AS1, CAS1

Introduction-

Drugs associated with CACNA1G-AS1

BCMA-CS1 HLE BiTE

Target

BCMA x CACNA1G-AS1 x CD3

Mechanism

BCMA inhibitors [+2]

Active Org.

Nanjing Anjin Pharmaceutical Co., Ltd.

Originator Org.

Nanjing Anjin Pharmaceutical Co., Ltd.

Active Indication

Multiple Myeloma

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CACNA1G-AS1

100 Translational Medicine associated with CACNA1G-AS1

0 Patents (Medical) associated with CACNA1G-AS1

368

Literatures (Medical) associated with CACNA1G-AS1

01 Nov 2024·Nature Chemical Biology

Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system

Article

Author: Zhang, Laixing ; Zeng, Jianwei ; Wang, Jiawei ; Liu, Zihe ; Yang, Maojun ; Wang, Hao ; Cao, Xueli ; Gao, Zhengyu ; Zhang, Yi ; Li, Feixue ; Feng, Yue

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems are prokaryotic adaptive immune systems against invading phages and other mobile genetic elements. Notably, some phages, including the Vibrio cholerae-infecting ICP1 (International Center for Diarrheal Disease Research, Bangladesh cholera phage 1), harbor CRISPR-Cas systems to counteract host defenses. Nevertheless, ICP1 Cas8f lacks the helical bundle domain essential for recruitment of helicase-nuclease Cas2/3 during target DNA cleavage and how this system accomplishes the interference stage remains unknown. Here, we found that Cas1, a highly conserved component known to exclusively work in the adaptation stage, also mediates the interference stage through connecting Cas2/3 to the DNA-bound CRISPR-associated complex for antiviral defense (Cascade; CRISPR system yersinia, Csy) of the ICP1 CRISPR-Cas system. A series of structures of Csy, Csy-dsDNA (double-stranded DNA), Cas1-Cas2/3 and Csy-dsDNA-Cas1-Cas2/3 complexes reveal the whole process of Cas1-mediated target DNA cleavage by the ICP1 CRISPR-Cas system. Together, these data support an unprecedented model in which Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system and the study also sheds light on a unique model of primed adaptation.

11 Sep 2024·Journal of the American Chemical Society

Topochemical Polymerization at Diacetylene Metal–Organic Framework Thin Films for Tuning Nonlinear Optics

Article

Author: Zhou, Guojun ; Jin, Zhi-Bin ; Huang, Zhehao ; Gu, Zhi-Gang ; Han, Yu ; Zhang, Jian

Developing the topochemical polymerization of metal-organic frameworks (MOFs) is of pronounced significance for expanding their functionalities but is still a challenge on third-order nonlinear optics (NLO). Here, we report diacetylene MOF (CAS-1-3) films prepared using a stepwise deposition method and film structural transformation approach, featuring dynamic structural diversity. The MOF structures were determined by the three-dimensional electron diffraction (3D ED) method from nanocrystals collected from the films, which provides a reliable strategy for determining the precise structure of unknown MOF films. We demonstrate the well-aligned diacetylene groups in the MOFs can promote topological polymerization to produce a highly conjugated system under thermal stimulation. As a result, the three MOF films have distinct NLO properties: the CAS-1 film exhibits saturable absorption (SA) while CAS-2 and CAS-3 films exhibit reverse saturable absorption (RSA). Interestingly, due to the topochemical polymerization of the MOF films, a transition from SA to RSA response was observed with increasing temperatures, and the optical limiting effect was significantly enhanced (∼46 times). This study provides a new strategy for preparing NLO materials and thermally regulation of nonlinear optics.

01 Aug 2024·Brain, Behavior, and Immunity

Inhibition of GSDMD-dependent pyroptosis decreased methamphetamine self-administration in rats

Article

Author: Wei, Wenting ; Si, Zizhen ; Ruan, Yuer ; Gong, Xinshuang ; Qian, Liyin ; Yu, Zhaoying ; Shen, Yao ; Liu, Yu ; Lin, Shujun

It is widely believed that the activation of the central dopamine (DA) system is crucial to the rewarding effects of methamphetamine (METH) and to the behavioral outcomes of METH use disorder. It was reported that METH exposure induced gasdermin D (GSDMD)-dependent pyroptosis in rats. The membrane pore formation caused by METH-induced pyroptosis may also contribute to the overflow of DA into the extracellular space and subsequently increase the DA levels in the brain. The present study firstly investigated whether the membrane pore information induced by GSDMD-dependent pyroptosis was associated with the increased DA levels in the ventral tegmental area (VAT) and nucleus accumbens (NAc) of rats self-administering METH and SY-SH5Y cells treated by METH. Subsequently, the effect of pore formation blockade or genetic inhibition of GSDMD on the reinforcing and motivational effect of METH was determined in rats, using the animal model of METH self-administration (SA). METH exposure significantly increased the activity of NLRP1/Cas-1/GSDMD pathway and the presence of pyroptosis, accompanied by the significantly increased DA levels in VTA and NAc. Moreover, intraperitoneal injections of disulfiram (DSF) or microinjection of rAAV-shGSDMD into VTA/NAc significantly reduced the reinforcing and motivational effect of METH, accompanied by the decreased level of DA in VTA and NAc. The results provided novel evidence that METH-induced pyroptosis could increase DA release in VTA and NAc via the NLRP1/Cas-1/GSDMD pathway. Additionally, membrane pores or GSDMD blockade could significantly reduce the reinforcing and motivational effect of METH. In conclusion, blocking GSDMD and membrane pore formation could be a promising potential target for the development of agents to treat METH use disorder.

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CACNA1G-AS1

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