NANOS3

Last update 08 May 2025

Basic Info

Synonyms

nanos C2HC-type zinc finger 3, Nanos homolog 3, NANOS1L

+ [4]

Introduction

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

100 Clinical Results associated with NANOS3

100 Translational Medicine associated with NANOS3

0 Patents (Medical) associated with NANOS3

1,060

Literatures (Medical) associated with NANOS3

01 Dec 2025·European Journal of Trauma and Emergency Surgery

Role of adenosine A3 receptor and endothelial nitric oxide synthase in patients with traumatic hemorrhagic shock

Article

Author: Öztaş, Yasin ; Demiryürek, Abdullah Tuncay ; Dana, Halime ; Tuğhan, Emre ; Günay, Nurullah ; Aslan, Yusuf Ertuğrul ; Şener, Elif Funda

AbstractBackgroundThe aim of this research is to access the expression of adenosine A3 receptor (ADORA3) and nitric oxide synthase 3 (NOS3) genes and serum levels of ADORA3 and NOS3 in patients with multiple trauma with hemorrhagic shock.Materials and methodsThe study was performed at Erciyes University between November 2022 and March 2024, in a prospective and controlled manner. Patients diagnosed with traumatic hemorrhagic shock and requiring transfusion in the emergency department were selected as the patients group. Gene expressions were analyzed using quantitative real-time PCR analysis in total RNA samples and serum levels of NOS3 and ADORA3 were detected using ELISA measurements.ResultsIn patients with multiple trauma, adenosine A3 receptor (ADORA3) gene expression showed a significant increase at discharge when compared to healthy controls (P < 0.05). However, serum levels of ADORA3 showed significant decreases at all stages (i.e. at admission, at 24 h, and at discharge) of patients. Although no significant changes were detected in NOS3 gene expression, marked decreases in serum NOS3 levels were observed at admission and at 24 h in multiple trauma patients (P < 0.05). ADORA3 and NOS3 gene expressions were found to be significantly diminished in nonsurvivors.ConclusionThe study emphasizes the importance of ADORA3 and NOS3 gene expressions in influencing shock progression in multiple trauma patients. The increase in ADORA3 gene expression may play a role in restoring vascular reactivity after traumatic shock. Decreased serum NOS3 and ADORA3 levels can contribute to the shock progression in the pathophysiology of multiple trauma.

01 Jun 2025·Current Computer-Aided Drug Design

Exploration of Pharmacological Mechanisms of Dapagliflozin against Type 2 Diabetes Mellitus through PI3K-Akt Signaling Pathway based on Network Pharmacology Analysis and Deep Learning Technology

Article

Author: Chen, Yufan ; Liu, Junru ; Li, Xingxing ; Zhang, Fen ; Liu, Xizhi ; Dong, Yang ; Wu, Jie ; Hu, Guoliang ; Shi, Shuai

Background:Dapagliflozin is commonly used to treat type 2 diabetes mellitus (T2DM). However, research into the specific anti-T2DM mechanisms of dapagliflozin remains scarce.Objective:This study aimed to explore the underlying mechanisms of dapagliflozin against T2DM.Methods:Dapagliflozin-associated targets were acquired from CTD, SwissTargetPrediction, and SuperPred. T2DM-associated targets were obtained from GeneCards and DigSee. VennDiagram was used to obtain the overlapping targets of dapagliflozin and T2DM. GO and KEGG analyses were performed using clusterProfiler. A PPI network was built by STRING database and Cytoscape, and the top 30 targets were screened using the degree, maximal clique centrality (MCC), and edge percolated component (EPC) algorithms of CytoHubba. The top 30 targets screened by the three algorithms were intersected with the core pathway-related targets to obtain the key targets. DeepPurpose was used to evaluate the binding affinity of dapagliflozin with the key targets.Results:In total, 155 overlapping targets of dapagliflozin and T2DM were obtained. GO and KEGG analyses revealed that the targets were primarily enriched in response to peptide, membrane microdomain, protein serine/threonine/tyrosine kinase activity, PI3K-Akt signaling pathway, MAPK signaling pathway, and AGE-RAGE signaling pathway in diabetic complications. AKT1, PIK3CA, NOS3, EGFR, MAPK1, MAPK3, HSP90AA1, MTOR, RELA, NFKB1, IKBKB, ITGB1, and TP53 were the key targets, mainly related to oxidative stress, endothelial function, and autophagy. Through the DeepPurpose algorithm, AKT1, HSP90AA1, RELA, ITGB1, and TP53 were identified as the top 5 anti-targets of dapagliflozin.Conclusion:Dapagliflozin might treat T2DM mainly by targeting AKT1, HSP90AA1, RELA, ITGB1, and TP53 through PI3K-Akt signaling.

01 Jun 2025·Environmental Pollution

Chlorophenols suppress gametogenesis by disrupting sex hormone signaling through DNA methylation in zebrafish

Article

Author: Shi, Jiamin ; Wei, Dongqiong ; Liu, Rongjian ; Samra ; Ma, Xuan ; Hu, Yan ; Huang, Dejun ; Qi, Yongmei ; Yuan, Cong

Chlorophenols (CPs) are toxic pollutants widely present in the water environment. Yet their specific influence on gametogenesis remains unclear. This study investigated the impact of 2,4-dichlorophenol and pentachlorophenol on the gametogenesis of zebrafish. Results showed reduced egg production and sperm density in CP-exposed zebrafish, with an increase in the proportion of early germ cells and a decrease in mature germ cells. Additionally, the expression of gametogenesis-related genes (nanos3, ccnd1, dmc1) was upregulated, together confirming CPs suppress gametogenesis. The study also assessed the effects of CPs on sex hormone signaling, revealing altered ratios of estradiol to 11-ketotestosterone and changed expression of hormone receptors (esrs and ar). Besides, the hypothalamic-pituitary-gonadal axis genes showed significantly change, indicating the disorder of sex hormone signaling. Moreover, CPs increased DNA methylation levels in gonads, especially at CpG sites in the ar promoter, which negatively correlated with ar expression. Furthermore, elevated DNA methyltransferase (dnmts) expression was observed, and there was a significant interaction between CPs and Dnmts, suggesting CPs influence DNA methylation pathways. Overall, CPs inhibit gametogenesis by disrupting hormone signaling through DNA methylation. This study provides a new perspective on the toxic mechanisms and the risks posed by CPs to aquatic organisms.

Analysis

Perform a panoramic analysis of this field.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

NANOS3

Basic Info

Related

Analysis