FOXP4

Last update 08 May 2025

Basic Info

Synonyms

FKHLA, FLJ40908, Fork head-related protein-like A

+ [3]

Introduction

Transcriptional repressor that represses lung-specific expression.

100 Clinical Results associated with FOXP4

100 Translational Medicine associated with FOXP4

0 Patents (Medical) associated with FOXP4

135

Literatures (Medical) associated with FOXP4

04 Nov 2024·Cancer Research

FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis

Article

Author: Xu, Dazhi ; Wu, Qian ; Chen, Jianwu ; Chan, Michael W.Y. ; Chen, Bonan ; Zhang, Jinglin ; Wang, Shouyu ; Fang, Canbin ; Wong, Kit Yee ; Chen, Huarong ; Tse, Gary M.K. ; Wu, William K.K. ; To, Ka-Fai ; Yu, Jun ; Liu, Xiaoli ; Xie, Fuda ; Hu, Jintao ; Wong, Chi Chun ; Kang, Wei ; Tsang, Chi Man ; Wang, Yuzhi ; Cheung, Alvin H.K. ; Lo, Kwok Wai

AbstractThe Hippo–YAP1 pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration. Dysregulation of Hippo–YAP1 signaling promotes initiation and progression of several types of cancer, including gastric cancer. As the Hippo–YAP1 pathway regulates expression of thousands of genes, it is important to establish which target genes contribute to the oncogenic program driven by YAP1 to identify strategies to circumvent it. In this study, we identified a vital role of forkhead box protein 4 (FOXP4) in YAP1-driven gastric carcinogenesis by maintaining stemness and promoting peritoneal metastasis. Loss of FOXP4 impaired gastric cancer spheroid formation and reduced stemness marker expression, whereas FOXP4 upregulation potentiated cancer cell stemness. RNA sequencing analysis revealed SOX12 as a downstream target of FOXP4, and functional studies established that SOX12 supports stemness in YAP1-induced carcinogenesis. A small-molecule screen identified 42-(2-tetrazolyl) rapamycin as a FOXP4 inhibitor, and targeting FOXP4 suppressed gastric cancer tumor growth and enhanced the efficacy of 5-fluorouracil chemotherapy in vivo. Collectively, these findings revealed that FOXP4 upregulation by YAP1 in gastric cancer regulates stemness and tumorigenesis by upregulating SOX12. Targeting the YAP1–FOXP4–SOX12 axis represents a potential therapeutic strategy for gastric cancer.Significance: Hippo–YAP1 signaling maintains stemness in gastric cancer by upregulating FOXP4, identifying FOXP4 as a stemness biomarker and therapeutic target that could help improve patient outcomes.

01 Nov 2024·Heliyon

Emerging roles of long non-coding RNA FOXP4-AS1 in human cancers: From molecular biology to clinical application

Review

Author: Yang, Jingjie

Forkhead box P4 antisense RNA 1 (FOXP4-AS1) is a long non-coding RNA (lncRNA) situated on the human chromosome 6p21.1 locus. Previous research has demonstrated that FOXP4-AS1 is dysregulated in various cancers and exhibits a dual purpose as a tumor suppressor or oncogene in specific types of cancer. The levels of FOXP4-AS1 are significantly correlated with clinical features of cancer as well as prognosis. Additionally, FOXP4-AS1 is stimulated by transcription factors ATF3, YY1, PAX5, and SP4. The molecular mechanisms of FOXP4-AS1 in cancer are quite complex. It competitively sponges multiple miRNAs, bidirectionally regulates the levels of host gene FOXP4, activates the PI3K/AKT, Wnt/β-catenin, and ERK/MAPK signaling pathways, and recruits chromatin-modifying enzymes or interacts with other proteins to regulate malignant phenotypes of tumors, including proliferation, invasion, epithelial-mesenchymal transition (EMT), and angiogenesis. In this review, we provide an overview of the latest developments in FOXP4-AS1 oncology research, outlines its molecular regulatory networks in cancer, and discusses its prospective relevance as a cancer therapeutic target as well as a biomarker for prognosis and diagnosis.

01 Oct 2024·Cell Death & Differentiation

Correction: Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2

Author: Xue, Ping ; Zhang, Caiyan ; Yang, Lan ; Xiao, Wenfeng ; Huang, Saihua ; Zhou, Yufeng ; Li, Hao ; Fu, Jinrong ; Han, Xiao

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FOXP4

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