SENP3

Last update 08 May 2025

Basic Info

Synonyms

DKFZP586K0919, DKFZp762A152, SENP3

+ [8]

Introduction

Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates (PubMed:16608850, PubMed:32832608, PubMed:36050397). Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability (PubMed:15743823). Deconjugates SUMO2 and SUMO3 from CDCA8 (PubMed:18946085). Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300 (PubMed:19680224). Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1 (PubMed:19015314). Plays a role in the regulation of sumoylation status of ZNF148 (PubMed:18259216). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Deconjugates SUMO2 from KAT5 (PubMed:32832608). Catalyzes desumoylation of MRE11 (PubMed:36050397).

100 Clinical Results associated with SENP3

100 Translational Medicine associated with SENP3

0 Patents (Medical) associated with SENP3

385

Literatures (Medical) associated with SENP3

01 Jun 2025·Environmental Research

Surface ozone pollution-driven risks for the yield of major food crops under future climate change scenarios in India

Article

Author: Kuttippurath, Jayanarayanan ; Anagha, K S

This study provides a comprehensive assessment of surface ozone (SurfO₃) evolution in India under the future shared socio-economic pathway scenarios (SSPs) of the Coupled Model Intercomparison Project phase-6 (CMIP6), and its implications for changes in relative yield loss (RYL) of wheat, rice and maize. Scenarios with insufficient efforts to reduce the emission of precursors (e.g. SSP3-7.0) lead to significant increases in RYL (∼20% for wheat and ∼7% for rice and maize) post-2050. Conversely, SSP1-2.6 and SSP2-4.5 help to minimise RYL by controlling emissions. Accumulated ozone above a threshold of 40 (AOT40) in the growth stages of crops may surpass safer limits (3 ppm.h) by six-fold in the Indo-Gangetic Plain (IGP) for rice and maize, and in Central India for wheat in the SSP3-7.0 and SSP5-8.5 scenarios. Furthermore, climate penalty on SurfO₃ is observed in rabi (winter: December-February) and post-kharif (post-monsoon: October-November) seasons, whereas kharif (summer: June-September) shows climate benefit in one model. Positive trends in climate penalties are observed in IGP during most seasons and in Central India during post-kharif and rabi. Wheat is most sensitive to emission pathways with high variability, while rice and maize show more stable projections. Undoubtedly, comprehensive strategies are required for crop yield enhancement, including stringent air pollution regulations, widespread adoption of clean energy, land use management and advancements in low-emission agricultural practices. Safeguarding agriculture productivity requires coordinated efforts to manage air quality and climate, ensuring a transition away from pathways like SSP3-7.0 and toward more sustainable, low-emission futures. Furthermore, efforts to address SurfO₃-induced crop yield losses in India are vital for informing strategies to ensure global food security.

01 Apr 2025·Ecology and Evolution

A Dark Future of Endangered Mountain Species, Parnassius bremeri, Under Climate Change

Article

Author: Koo, Kyung Ah ; Park, Seon Uk

ABSTRACTClimate and land‐use changes are key factors in the habitat loss and population declines of climate change‐sensitive endangered species. We assessed the climate change effects on the distribution of Parnassius bremeri, a critically endangered wildlife species in the Republic of Korea, in association with food availability (Sedum kamtschaticum and Sedum aizoon), land‐use change, and dispersal limitation. We first predicted the current and future distributions of P. bremeri, S. kamtschaticum, and S. aizoon using the presence/absence data and current (2000) and future climate data (2050, 2100) with BioMod2, an ensemble platform for species distribution model projections. Then, the dispersal capacity of P. bremeri and land‐use change were coupled with SDMs using MigClim. We used future climate and land‐use changes predicted according to the SSP scenarios (SSP1‐2.6, SSP2‐4.5, and SSP3‐7.0) and the dispersal model estimated from previous studies. The current distributional areas of P. bremeri were predicted to be about 10,956 km2 without land‐cover coupling and 8.861 km2 with coupling, showing land‐cover decreased by about 19% of the suitable habitat. The future predictions under climate change only showed the distribution reduced by 56% and 50% in 2050 and 2100 under SSP1‐2.6, respectively, 55% and 48% under SSP2‐4.5, and 44% and 14% under SSP3‐7.0. Applying land‐use change and dispersal capacity further decreased the future distribution of P. bremeri but trivially (about 0.42% on average). The strict conservation policies and measures for P. bremeri's habitats explain the trivial additional decrease, delaying its habitat loss. However, our results suggest that such efforts cannot halt the climate change‐driven habitat loss trend of P. bremeri. Strong climate mitigation efforts and promoting the species' adaptive capacity are the only ways to reverse the tragic decline of climate‐sensitive species.

01 Apr 2025·International Journal of Biological Macromolecules

Determination of enzyme kinetic parameters of fast-acting Schizosaccharomyces pombe Ulp1 catalytic domain using Forster resonance energy transfer (FRET) assay

Article

Author: Mohanty, Shilpa ; Khasa, Yogender Pal ; Babbal

The SUMO fusion technology has immensely contributed to the soluble production of therapeutics and other recombinant proteins in E. coli. The structure-based functionality of SUMO protease has remained the primary determinant for choosing SUMO as a solubility enhancer tag. This study details the quantification of kinetic parameters of commercially relevant S. pombe Ulp1 catalytic domain by employing a Forster resonance energy transfer (FRET) based assay. The energy transfer between the fluorophores allowed to elucidate the kinetic parameters precisely. For the FRET assay, the ECFP-SpSUMO-EYFP construct was successfully cloned in the pET28a vector. The fusion protein was efficaciously expressed and purified near homogeneity. The assay employed provided a real-time investigation of SpUlp1 catalysis. The enzyme turnover number (k_cat) was computed as 9.08 s^-1. The Michaelis-Menten constant, K_M was determined as 0.65 × 10¹ μM with a maximum velocity (V_max) of 0.045 μM/s. The substrate specificity ratio, k_cat/K_M was calculated to be 1.39 × 10⁶ M^-1 s^-1. Using the FRET assay approach, the fast-acting nature of the SpUlp1 was analyzed in real-time at even 10³ times higher molar substrate concentration. Thus, the kinetics of commercially relevant SpUlp1 was successfully demonstrated along with its large-scale production at 50 L bioreactor, where the maximum product concentration was 4.8 g/L. Additionally, the S. pombe SUMO used in the current study could potentially replace the S. cerevisiae SUMO as a solubility enhancer fusion tag.

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SENP3

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