CCDC25

Last update 08 May 2025

Basic Info

Synonyms

CCDC25, coiled-coil domain containing 25, Coiled-coil domain-containing protein 25

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Introduction

Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174).

100 Clinical Results associated with CCDC25

100 Translational Medicine associated with CCDC25

0 Patents (Medical) associated with CCDC25

Literatures (Medical) associated with CCDC25

01 May 2025·Annals of Surgical Oncology

ASO Author Reflections: Coiled-Coil Domain-Containing Protein 25 Expression Related to the Poor Prognosis in Esophageal Squamous Cell Cancer, Especially in the Case with High Neutrophil Counts

Article

Author: Tsujimoto, Hironori ; Suzuki, Takafumi

01 May 2025·Annals of Surgical Oncology

Clinical Significance of Coiled-Coil Domain-Containing Protein 25 Expression in Esophageal Squamous Cell Carcinoma

Article

Author: Ishibashi, Yusuke ; Sato, Kimiya ; Shinada, Hanae ; Tsujimoto, Hironori ; Itazaki, Yujiro ; Watanabe, Takanori ; Kariya, Risa ; Mochizuki, Satsuki ; Uehata, Naoyuki ; Kishi, Yoji ; Suzuki, Takafumi ; Ueno, Hideki ; Fujishima, Seiichiro

AbstractBackgroundNeutrophil extracellular traps (NETs) have been implicated in cancer progression by enhancing cancer cell motility through the coiled-coil domain-containing protein 25 (CCDC25).ObjectiveThis study aimed to evaluate the prognostic value of CCDC25 expression in patients with esophageal squamous cell carcinoma (ESCC).MethodTissue specimens from patients who underwent radical esophagectomy for ESCC were analyzed to investigate the relationship between CCDC25 expression, clinicopathological features, and prognosis. Western blotting was conducted to compare CCDC25 expression in tumor and non-tumorous tissues (n = 4). Immunohistochemical staining was performed to categorize patients into two groups based on CCDC25 expression: CCDC25high (n = 80) and CCDC25low (n = 40).ResultsCCDC25 expression was significantly higher in tumor tissues compared with non-tumorous tissues (p = 0.006). Patients in the CCDC25high group had a higher likelihood of poorly differentiated tumors; however, no significant differences were observed in the other clinicopathological features between the two groups. High CCDC25 expression was associated with significantly lower relapse-free survival (RFS) rate (p = 0.03) but not overall survival (OS) [p = 0.07]. Multivariate analysis revealed that high CCDC25 expression and tumor depth were independent predictors of both RFS and OS. Furthermore, high CCDC25 expression was significantly associated with worse prognosis in patients with high postoperative neutrophil counts (≥ 9600/µL) and those with postoperative infectious complications.ConclusionsHigh expression of CCDC25 was identified as an unfavorable prognostic factor in patients with ESCC, particularly in those with elevated postoperative neutrophil counts. Targeting CCDC25 could potentially improve prognosis in specific subgroups of patients with ESCC.

01 Apr 2025·Journal of Allergy and Clinical Immunology

Eosinophil extracellular traps drive T follicular helper cell differentiation via VIRMA-dependent MAF stabilization in bullous pemphigoid

Article

Author: Dang, Erle ; Chu, Mengyang ; Pang, Bingyu ; Zhou, Yifan ; Zhang, Chen ; Miao, Haijun ; Wang, Gang ; Li, Xia ; Chen, Jiaoling ; Qiao, Hongjiang ; Shao, Shuai ; Fang, Hui ; Li, Liang ; Bai, Yaxing ; Xue, Ke ; Tang, Xin ; Shen, Shengxian

BACKGROUNDBullous pemphigoid (BP) is an autoimmune blistering disease characterized by the presence of pathogenic autoantibodies and a substantial influx of immune cells into skin lesions. However, the role of eosinophils in BP remains inadequately elucidated.OBJECTIVEWe sought to determine the pathologic involvement of eosinophils and eosinophil extracellular traps (EETs) in BP.METHODSHuman samples collected from BP patients and healthy controls were utilized to explore the potential role of eosinophils and their EETs in BP patients through serologic detection, flow cytometry, and immunofluorescence. Naive CD4⁺ T cells isolated from healthy donors were stimulated and subjected to further analysis via RNA sequencing. We additionally evaluated the potential of targeting EETs in BP180-immunized BP-like mice and in in vitro settings.RESULTSWe found that elevated levels of eosinophils and EETs in BP patients correlated with disease severity. The DNA components within EETs played a crucial role in driving the differentiation of naive CD4⁺ T cells into follicular helper T (Tfh) cells by activating coil domains containing 25 (CCDC25). Treatment with DNase I, which disrupts the structural integrity of EETs, or neutralizing antibody against CCDC25 reduced the expansion of Tfh cells and suppressed the production of autoantibodies in BP180-immunized BP-like mouse models. Additionally, we discovered that EETs induced the N⁶-methyladenosine methylation of the transcription factor musculoaponeurotic fibrosarcoma (MAF) via the DNA-CCDC25-VIRMA pathway, thereby enhancing its mRNA stability and promoting Tfh cell differentiation.CONCLUSIONOur study revealed a previously unrecognized mechanism by which EETs trigger abnormal Tfh cell differentiation through CCDC25, followed by Vir-like m⁶A methyltransferase-associated protein (VIRMA)-mediated N⁶-methyladenosine modification of MAF. These insights provide promising avenues for the development of targeted therapeutic interventions in the field of BP and potentially other autoimmune diseases.

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