SCP2

Last update 08 May 2025

Basic Info

Synonyms

Acetyl-CoA C-myristoyltransferase, Non-specific lipid-transfer protein, NSL-TP

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Introduction

Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity). Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (PubMed:17157249, PubMed:7642518, PubMed:8300590). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity).

100 Clinical Results associated with SCP2

100 Translational Medicine associated with SCP2

0 Patents (Medical) associated with SCP2

636

Literatures (Medical) associated with SCP2

01 May 2025·The Prostate

Transcriptome‐Wide Association Study Identified Novel Blood Tissue Gene Biomarkers for Prostate Cancer Risk

Article

Author: Zhong, Hua ; Yu, Jie ; Liu, Yanhui ; Liu, Jiawen ; Wang, Liang ; Wu, Lang ; Zhang, Zichen ; Zhu, Jingjing ; Deng, Youping ; Sun, Yanfa ; Nakamura, Akira ; Zeng, Guanghua ; Wang, Fubo ; Lin, Xin ; Zhou, Dan ; Wu, Chong

ABSTRACTObjectiveA number of susceptibility genes in prostate tissue have been identified to be associated with prostate cancer (PCa) risk. However, the reported genes based on assessing prostate tissue could not fully explain PCa genetic susceptibility. It is believed that genes functioning in the immune system may fill in the gap of some missing heritability.MethodsTo study potential susceptibility genes acting in such pathways, we performed a transcriptome‐wide association study (TWAS) of 79,194 PCa cases and 61,112 control of European ancestry by using three sets of gene expression prediction models of blood tissue.ResultsA total of 470 genes were associated at false discovery rates‐corrected p‐value < 0.05, of which 51 were implicated as likely causal genes based on fine‐mapping analysis. Compared with previous literature, 133 novel genes were reported for the first time. Of the identified genes, five (CREB3L4, GSTP1, MAPK3, NKX3‐1, and PIK3C2B) were enriched in a PCa signaling pathway, and 128 genes were enriched in five PCa categories. Importantly, 13 genes (SCP2, LMNA, ZNF148, H2AFV, TACC1, FLII, SUPT4H1, CD300LF, MYO9B, COX6B1, CTSA, EP300, and TSPO) showed consistent effect directions for the measured levels in circulating immune cells between PCa cases and controls, and 14 genes (SLC39A1, ZBTB7B, TRIM59, NCEH1, N4BP2, TAGAP, TACC1, TRAF1, AIP, SECTM1, C18orf54, ZNF793, YIF1B, and TSPO) showed consistency for levels in blood exosomes between PCa patients and controls.ConclusionThe identified blood‐based candidate susceptibility genes provide further insights into the genetic basis of PCa risk.

01 Mar 2025·International Journal of Biological Macromolecules

Identification of two novel α-amylase inhibitory activity peptide from Russian sea cucumber body wallprotein hydrolysate

Article

Author: Geng, Jieting ; Ge, Xiaofan ; Wu, Tao ; Zhang, Min ; Jin, Yan ; Sun, Yuting ; Chen, GuoXing ; Sui, Wenjie

This study aimed to identify novel α-amylase inhibitory peptides from Russian sea cucumbers and elucidate their inhibitory mechanisms. Among the 52 identified sea cucumber peptide (SCP), two peptides with potential α-amylase inhibitory activity, FPSPPLVA (SCP1) and GPPMPPPPLP (SCP2), were selected from the sequences researched. The results showed that both SCP1 and SCP2 exhibited α-amylase inhibitory activity with IC₅₀ of 0.92 ± 0.03 mg/mL (SCP1) and 2.01 ± 0.02 mg/mL (SCP2), respectively. Molecular docking studies revealed the potential interaction mechanism between these inhibitors and α-amylase. Two peptides interacted with Gln63, Tyr151, Thr163, Lys200, His201, His305, and Ala307 within the α-amylase active site. The formation of hydrogen bonds and hydrophobic interactions between the inhibitors and α-amylase impedes the formation of enzyme-substrate complexes and subsequent glycosylation. Lineweaver-Burk plot indicated that both SCP1 and SCP2 act as reversible mixed inhibitors of α-amylase. Furthermore, the results of infrared and circular dichroism spectroscopy confirmed the formation of non-covalent binding complexes between SCP and amylase, leading to alterations in the secondary structure of the enzyme.

01 Mar 2025·Plant Disease

Leaf Spot of Acorus calamus var. angustatus Caused by Alternaria alternata in Anhui Province, China

Article

Author: Liu, Dong ; Song, Xiaohe ; Yu, Bixia ; Li, Ping

Acorus calamus var. angustatus Besser, a perennial herb of the Araceae family, was first reported in the Shen Nong's Herbal Classic and is widely distributed in southern China (Li 1979). It is important in traditional Chinese medicine for treating heart, stomach, and brain ailments (Lam et al. 2016). In March 2024, leaf spots were found on its leaves in a traditional Chinese medicine planting base in Yuexi County (30°91′56″ N, 116°19′24″ E), Anhui Province, with an incidence of about 35%. The symptoms began as small, light brown lesions that expanded, resulting in necrotic lesions ranging from 1 to 8 mm in diameter with brown halos. 3 × 3 mm sections, including both symptomatic and asymptomatic tissues, were cut from six infected plants. They were disinfected in 75% ethanol for 30 s, washed three times with sterile distilled water, transferred to Petri dishes containing potato dextrose agar (PDA) and incubated at 25 °C in the dark. Purified fungal isolates were obtained by the single-spore isolation method. The colonies on PDA initially appeared white, gradually became olive-green with 1 to 3 mm white margins and abundant aerial hyphae, while the reverse was greyish green to black. The conidia were light brown, ellipsoidal, obclavate, and 10.0 to 49.5 µm × 4.5 to 16.4 µm (mean 23.9 × 10.2 µm, n=50) in size, with 0 to 6 transverse septa and 0 to 6 longitudinal or oblique septa (n=50). Conidiophores were thick, dark brown, single-celled, with multiple conidial scars, measuring 12.8 to 146.8 × 2.9 to 6.1 (mean 50.6 × 4.2) µm (n=50). Based on above observations, the pathogen were identified as Alternaria spp. (Simmons 2007). Three representative isolates, SCP-1, SCP-2, and SCP-3 were selected for molecular identification. The Internal transcribed spacer (ITS), Alternaria major allergen (Alt a 1), and translation elongation factor 1-alpha (TEF1) genes were amplified with the primers ITS1/ITS4 (White et al. 1990), Alt-for/Alt-rev (Woudenberg et al. 2015) and EF1-728F/EF1-986R (Carbone and Kohn 1999), respectively. The sequences of the three isolates were consistent, and the sequences of isolate SCP-1 were submitted to NCBI GenBank (ITS, PP723104; Alt a1, PP708704; TEF1, PP708703). The ITS region of isolate SCP-1 was 100% similar to A. alternata TCS3002 (MN394880, Wang et al. 2023), the Alt a 1 gene was 100% similar to A. alternata CBS 620.83 (KP123868), and the TEF1 gene was 100% similar to A. alternata CBS 916.96 ex-type (KC584634). A phylogenetic tree based on sequences of ITS, Alt a 1 and TEF1 genes was constructed using the neighbor-joining method in MEGA 7 software, confirming the fungus as A. alternata. Three healthy plants of A. calamus var. angustatus were spayed with conidial suspension (1 × 107 conidia/ml) of isolate SCP-1. Three additional plants sprayed only with sterile distilled water were controls. All plants were covered with plastic bags to maintain a relative humidity of 90% for 48 h and incubated at 25 °C under a 12-h light photo-period. Twelve days post-inoculation, brown necrotic lesions developed on the inoculated leaves, enlarged, and the symptoms were similar to the original ones. The control plants remained healthy. The fungus was re-isolated from the infected plants and confirmed by morphological traits and molecular methods, fulfilling Koch's postulates. To our knowledge, there are no other reports of this fungus on A. calamus var. angustatus in Anhui, China. This report will help identify the disease based on field symptoms and provide a basis for disease management strategies of A. calamus var. angustatus.

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SCP2

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