ITGA7

Last update 08 May 2025

Basic Info

Synonyms

Integrin alpha-7, Integrin alpha-7 70 kDa form, Integrin alpha-7 heavy chain

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Introduction

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.

100 Clinical Results associated with ITGA7

100 Translational Medicine associated with ITGA7

0 Patents (Medical) associated with ITGA7

354

Literatures (Medical) associated with ITGA7

01 Aug 2025·The Veterinary Journal

Comparison of equine-induced pluripotent stem cell characteristics induced on different cell adhesion substrates

Article

Author: Arai, Katsuhiko ; Usui, Tatsuya ; Sato, Kota ; Tamura, Norihisa ; Kushida, Chiho ; Kasashima, Yoshinori

This study evaluated the effects of cell adhesion substrates that lead to the generation of equine-induced pluripotent stem cells (eiPSC) from embryonic skin fibroblasts by lipofection of plasmid vectors expressing five reprogramming factors. The reprogramming efficiency of cells induced on the E8 fragment of laminin-511 (eiPSC-511) was higher than that on Geltrex containing laminin-111 as a major laminin (eiPSC-111), and supplementation with a cocktail of small molecular compounds increased the number of iPSC colonies on both substrates. In the cell proliferation assay, eiPSC-511 showed higher growth activity than eiPSC-111. Although no significant changes were observed in the expression of pluripotency markers between eiPSC-111 and eiPSC-511, the expression of DPPA3 was significantly upregulated in both iPSCs by reprogramming, suggesting that DPPA3 was a sensitive pluripotent marker for equine iPSC. While both iPSCs expressed high mRNA level of integrin alpha6 and beta1 subunits, mRNA level corresponding to ITGA3 and ITGA7 significantly increased in eiPSC-511 in comparison to those in eiPSC-111. These results suggested that the binding strength to the substrate in eiPSC-511 was stronger than that in eiPSC-111. On the contrary, although no significant differences were observed in the histology of teratomas, increased in vitro differentiation into three germ layers in eiPSC-111 was shown compared to those in eiPSC-511. Thus, these results contributed to the improved generation of iPSC in horses.

01 Apr 2025·Cell Death & Differentiation

Tenascin-C promotes bone regeneration via inflammatory macrophages

Article

Author: Wang, Lijun ; Xing, Wenhui ; Feng, Heng ; Jiang, Bo ; Suo, Jinlong ; Ren, Qian ; Hu, Xuye ; Zou, Weiguo

AbstractDuring the early stage of tissue injury, macrophages play important roles in the activation of stem cells for further regeneration. However, the regulation of macrophages during bone regeneration remains unclear. Here, the extracellular matrix (ECM) tenascin-C (TNC) is found to express in the periosteum and recruit inflammatory macrophages. TNC-deficiency in the periosteum delays bone repair. Transplantation of macrophages derived from injured periosteum is able to rescue the decreased skeletal stem cells and impaired bone regeneration caused by TNC deficiency. The cell communication analysis identifies ITGA7 as a TNC receptor contributing to the recruitment of inflammatory macrophages. TNC expression declines in aged mice and the exogenous delivery of TNC significantly promotes bone regeneration after aging through the recruitment of macrophages. Taken together, this study reveals the regulation of macrophage recruitment and its function in the activation of skeletal stem cells after bone injury, providing a strategy to accelerate bone regeneration by TNC delivery.

01 Mar 2025·American Journal of Obstetrics and Gynecology

Inherited and de novo variants in young females potentially associated with pelvic organ prolapse

Article

Author: Pollak, Agnieszka ; Szepieniec, Wioletta Katarzyna ; Sadakierska-Chudy, Anna ; Szymanowski, Paweł ; Płoski, Rafał ; Lebioda, Arleta ; Bartosiewicz, Angelika

BACKGROUNDPelvic organ prolapse is a common condition usually affecting postmenopausal women, but it is also seen in about 10% of women aged 20 to 39 years. In young females, genetic factors seem to be of particular interest.OBJECTIVEThis study aimed to identify inherited and de novo variants relevant to pelvic organ prolapse in young females without a family history.STUDY DESIGNA total of 25 women aged ≤40 years with parity ≤2 and Pelvic Organ Prolapse Quantification stage ≥II were included in the study. Moreover, females had no history of pelvic organ prolapse and any previous history of urogynecological surgery. A trio-based exome analysis was performed on patients and both their parents. Bioinformatic analysis of raw whole exome sequencing data and genetic variant prioritization were performed using in-house bioinformatic pipeline. The ClinVar database, GeneCard, and the Human Protein Atlas were used to determine clinical significance, disease associations, and linked phenotypes of the genetic variants. The impact of causative genetic variants on protein structure and function was assessed using various prediction tools including Sorting Intolerant From Tolerant, PolyPhen2, MutPred2, Phyre2, and SNPeffect 4.0. To determine the molecular interaction network of the proteins, Search Tool for the Retrieval of Interacting Genes database was applied.RESULTSThe mean age of women was 33.50 (±3.07) years, the mean body mass index value was 21.80 (±2.07), and the number of parity was 1.76 (±0.44). In the study group, 18 of 25 women required surgical treatment. Whole exome sequencing analysis identified 76 de novo variants, but only 19 were missense and 2 were nonsense variants. Three genetic variants in CSPG4, ITGA7, and MT-CO3 genes appear potentially relevant to pelvic organ prolapse. Interestingly, paternally inherited variants in SGCG, CYP24A1, and TK2 genes likely related to pelvic organ prolapse were found in carriers of new de novo variants.CONCLUSIONIn this study, no common genetic variants were found in the female group. Potentially causative patient-specific variants were found in genes related to extracellular matrix, mitochondria, or skeletal muscle conditions. The uncovered genetic variants presumably disrupt the functioning of muscles and mitochondria, which may consequently lead to pelvic floor dysfunction in young women.

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ITGA7

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