NIBAN1

Last update 08 May 2025

Basic Info

Synonyms

C1orf24, Cell growth-inhibiting gene 39 protein, FAM129A

+ [6]

Introduction

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).

100 Clinical Results associated with NIBAN1

100 Translational Medicine associated with NIBAN1

0 Patents (Medical) associated with NIBAN1

Literatures (Medical) associated with NIBAN1

19 Dec 2024·Investigative Ophthalmology & Visual Science

Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis

Article

Author: Edupuganti, Neel ; Altman, Jeremy ; Sharma, Shruti ; Robinson, Rebekah ; Zhi, Wenbo ; Greenway, Grace ; Glass, Joshua ; Sharma, Ashok ; Lee, Tae Jin

PurposeInterleukin-6 (IL-6) is an inflammatory cytokine implicated in various retinal pathologies and functions primarily through two signaling pathways: cis-signaling via IL-6 binding to its membrane-bound receptor (IL-6Rα), and trans-signaling via IL-6 binding to soluble IL-6 receptor (sIL-6R). Because the differential effects of IL-6 signaling in retinal Müller glial cells (MGCs) remain unclear, we generated an MGC-specific Il6ra-/- knockout (KO) mouse to eliminate IL-6Rα and, consequently, IL-6 cis-signaling in MGCs. In this study, we examined the proteomic changes in MGCs isolated from KO mice lacking a functional IL-6Rα.MethodsThe proteomes of MGCs isolated from wild-type (WT) and KO mice were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and validated by parallel reaction monitoring (PRM). Relevant biological functions and pathways were examined using Gene Ontology and Ingenuity Pathway Analysis.ResultsLC-MS/MS detected 1866 proteins, of which 81 were significantly altered (41 upregulated, 40 downregulated). PRM analysis confirmed differential expression of Ptgis (fold change [FC] = 3.63), Dpep1 (FC = 2.79), Fmo1 (FC = 2.77), Igfbp7 (FC = 2.07), Rpb1 (FC = 1.73), Pygp (FC = 1.46), Niban 1 (FC = 0.58), Mest (FC = 0.48), and Aldh3a1 (FC = 0.30). The significantly altered proteins are involved in oxidative stress balance, inflammation, mitochondrial dysfunction, and regulation of vascular endothelial growth factor (VEGF) signaling.ConclusionsThe absence of IL-6Rα in KO MGCs corresponded to significant changes in their proteomic profile, highlighting the impact of autocrine IL-6 signaling on MGC function. This study provides a basis for future research evaluating distinct roles of IL-6 in MGCs and subsequent effects on retinal pathology.

01 Jul 2024·Genes & Diseases

Transcriptomic analysis reveals that NIBAN1 overexpression is associated with BRAFV600E mutation and increases the aggressiveness of thyroid cancer

Article

Author: Ribeiro Carneiro, Thaise Nayane ; Kuroshu, Reginaldo Massanobu ; Diana, Paula ; Carvalheira, Gianna Maria Griz ; Cerutti, Janete Maria

01 Apr 2024·Journal of Cellular and Molecular Medicine

Integration of single‐cell and RNA‐seq data to explore the role of focal adhesion‐related genes in osteoporosis

Article

Author: Yang, Jiajie ; Chen, Aimin ; Fu, Qiang ; Lu, Nan ; Shi, Xiaojian ; Chen, Ye ; Lu, Jiajia ; Mao, Jianyu

AbstractIntegrin‐based focal adhesion is one of the major mechanosensory in osteocytes. The aim of this study was to mine the hub genes associated with focal adhesion and investigate their roles in osteoporosis based on the data of single‐cell RNA sequencing and RNA‐sequencing. Two hub genes (FAM129A and RNF24) with the same expression trend and AUC values greater than 0.7 in both GSE56815 and GSE56116 cohorts were uncovered. The nomogram was created to predict the risk of OP based on two hub genes. Subsequently, the competing endogenous RNA network was established based on two hub genes, 14 microRNAs and five long noncoding RNAs. Meanwhile, transcription factors‐hub gene network was established based on two hub genes and 14 TFs. Finally, 73 drugs were predicted, of which there were 13 drugs targeting FAM129A and 66 drugs targeting RNF24. In both mouse and human blood samples, FAM129A expression was decreased in granulocytes and RNF24 expression was increased in monocytes. In the mouse experiment, FAM129A and anti‐RNF24 were found to partially alleviate the progression of osteoporosis. In conclusion, two hub genes related to focal adhesion were identified by combined scRNA‐seq and RNA‐seq analyses, which might supply a new insight for the treatment and evaluation of OP.

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