NOC2L

Last update 08 May 2025

Basic Info

Synonyms

DKFZP564C186, NET15, NET7

+ [8]

Introduction

Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

100 Clinical Results associated with NOC2L

100 Translational Medicine associated with NOC2L

0 Patents (Medical) associated with NOC2L

667

Literatures (Medical) associated with NOC2L

01 Aug 2025·Water Research

Genome-resolved metagenomic analysis reveals a novel denitrifier with truncated nitrite reduction pathway from the genus SC-I-84

Article

Author: Lin, Yanting ; Meng, Fangang ; Chen, Qianqian ; Li, Jiapeng ; Zuo, Xiaotian

Understanding the genomic and ecological traits of partial denitrification (PD) bacteria is of high importance for developing wastewater treatment technologies. In this study, a PD-based bioreactor was operated, resulting in a mixed culture dominated by a potentially novel PD functional bacterium (SC-I-84). Progressively increased activity in both nitrate reduction and nitrite production were observed in the SC-I-84 enrichment system, whereas the nitrite reduction activity was always negligible. The phylogenetic analysis indicated that SC-I-84 was closely related to an uncultured beta-proteobacterium (99 %), whereas its denitrification functional genes (napA, napB, narV, and narY) exhibited evidence of co-evolution with chromosomal genes from the genus Cupriavidus, order Burkholderiales. In the genetic sketch of SC-I-84, only nitrate-reduction genes (nar and nap) were identified, whereas nitrite-reduction genes (nir) were absent. Notably, nitrate reduction genes were adjacent to carbon metabolism genes (sucB/C, mdh, idh) and a high abundance of tricarboxylic acid (TCA) cycling genes were found. This can promote the utilization efficiency of electron donors by nitrate reduction genes in SC-I-84, thus enhancing the denitrification activity. Furthermore, SC-I-84 positively cooperated with some bacteria that participate in nitrogen and carbon metabolism and other PD bacteria, but negatively interacted with full-denitrification bacteria. These results indicate that the enrichment of SC-I-84 restricted the growth of full-denitrification bacteria, aiding in the maintenance of a stable PD process. Taken together, the meta-genomic analysis of the novel PD functional bacterium is expected to enhance our understanding of PD processes and aid in the development of PD-based wastewater treatment processes.

01 Jul 2025·Journal of Hazardous Materials

Comprehensive revealing the destructive effect and inhibitory mechanism of oxytetracycline on aerobic denitrification bacteria Acinetobacter sp. AD1 based on cell state, electron behavior and intracellular environment

Article

Author: He, Ting ; Bao, Jianguo ; Cheng, Benai ; Zhou, Yu ; Mao, Qidi ; Zhang, Yi ; Du, Jiangkun

The wide application and low utilization rate of oxytetracycline (OTC) make it often detected in wastewater, which may cause harmful effects on microbial denitrification. Aerobic denitrification (AD) as a new microbial denitrification technology has obvious advantages. However, systematic studies on the effects of OTC on it are lacking. In this study, the effect of OTC on AD was comprehensively explored from multiple perspectives, the main results are as follows. From the perspective of bacterial performance, OTC inhibited AD bacteria growth, denitrification efficiency, and caused serious damage to cell morphological structure, results of CCK-8 confirmed that bacterial activity was significantly affected. From the perspective of electron behavior, OTC decreased electron-producing capacity of carbon metabolism, reduced activity of the electron transport system, inhibited the electron consumption of NAR and NIR to varying degrees, thus increased the risk of nitrite accumulation. From the perspective of intracellular environment, OTC broke redox balance and antioxidant mechanism, related carbon and nitrogen cycle functional genes were down-regulated, affected amino acid, organic acid and nucleotide metabolic processes. The above results provide important information for evaluating the potential risks of antibiotics on the application of AD, and provide key background and theoretical support for stabilizing the technology.

01 Jul 2025·Environmental Research

Water-lifting aerator coupled with sponge iron-enhanced biological aerobic denitrification to remove nitrogen in low C/N water source reservoirs: effect and mechanism

Article

Author: Du, Quanjie ; Zhang, Fei ; Zhangsun, Xuanzi ; Cao, Jian ; Huang, Tinglin

Nitrogen pollution in drinking water reservoirs is an urgent problem faced all over the world. This study investigated the effect and mechanism of sponge iron (SI) as inorganic electron donors to drive biological aerobic denitrification coupled with water-lifting aerator system (WLASI) for water quality improvement in low C/N water source reservoirs. Targeted pollutants were significantly removed in the WLASI system (30.97 % for total nitrogen, 76.31 % for total phosphorus, 13.35 % for chemical oxygen demand, 97.63 % for 2-methylisoborneol, 93.59 % for algae density). The study found that in the water column of WLASI system, the diversity and relative abundance of aerobic denitrifiers were considerably enhanced, such as Mycobacterium and hgcI_clade, relative abundance of periplasmic nitrate reductase (NAP) and nitrite reductase (NIR) associated with denitrification were 3.65 and 2.15 times higher in day-32 than in day-0. Furthermore, the enrichment of the napAB and nirKS genes, which encodes the synthesis of NAP and NIR in the WLASI system. The findings indicate the WLASI system achieves nitrogen removal through the enhancement of microorganisms, and represents a promising and innovative in-situ remediation method for reservoirs.

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