ADI1

Last update 08 May 2025

Basic Info

Synonyms

1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring)

+ [17]

Introduction

Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 (PubMed:14718544). Necessary for hepatitis C virus replication in an otherwise non-permissive cell line (PubMed:11602742).

100 Clinical Results associated with ADI1

100 Translational Medicine associated with ADI1

0 Patents (Medical) associated with ADI1

408

Literatures (Medical) associated with ADI1

01 Apr 2025·Carbohydrate Polymers

Coordinated transcriptional regulation of carbohydrate-related pathways contributes to the difference of starch accumulation between starchy cassava and sugary cassava

Article

Author: Tie, Weiwei ; Zhang, Jiaming ; Yang, Jinghao ; Hu, Wei ; Ding, Zehong ; Meng, Xianwei ; Fu, Lili ; Chen, Ganlu ; Yan, Yan ; Qiu, Xianjin

Cassava is a significant starchy root crop providing staple foods for millions of people globally. However, the metabolic differences and regulatory mechanisms underlying starch accumulation remain largely elusive in cassava. In this work, scanning electron microscopy, metabolome, and transcriptome were analyzed in parallel between starchy cassava (SC205) and sugary cassava (SM) during storage root (SR) development. Many carbohydrate-related metabolites (including fructose-6-phosphate and glucose-6-phosphate) were differentially accumulated between SC205 and SM. Further analysis unveiled coordinated metabolomic and transcriptomic changes in sucrose and starch metabolism, glycolysis and TCA cycle, lipid metabolism, and lignin and flavonoid biosynthesis during SR development, but with distinct abundance patterns between SC205 and SM. Specifically, bZIP2 could directly bind to the promoters of APL1, ISA1, and GBSS1 and promote their expression levels in SC205, but these interactions were absent in SM. Transient silencing of APL1, ISA1, or GBSS1 resulted in significant decreases in starch contents. Transient silencing of bZIP2 suppressed the expression of APL1, ISA1, and GBSS1, and accordingly, decreased the starch contents. These results suggest a crucial contribution of coordinated regulation of carbohydrate-related pathways/genes to the difference of starch accumulation between starchy cassava and sugary cassava, providing useful information for starch improvement in the future.

24 Mar 2025·Bioscience, Biotechnology, and Biochemistry

Prokaryotic ATP-binding cassette type F proteins in overcoming ribosomal stalling: mechanisms, evolution, and perspective for applications in bio-manufacturing

Review

Author: Takada, Hiraku ; Oshima, Taku ; Sugimoto, Ryota

AbstractATP-binding cassette type F (ABCF) proteins are key components of prokaryotic translation systems, resolving ribosomal stalling. These adenosine triphosphatases (ATPases) contain 2 ATPase domains and an interdomain linker, the length and composition of which are key determinants of their function. Antibiotic resistance ABCF proteins counteract ribosome-targeting antibiotics by binding to the E site of the 70S ribosome, promoting drug dissociation. In contrast, housekeeping ABCF proteins, such as YfmR and YkpA in Bacillus subtilis, resolve intrinsic translation challenges without conferring antibiotic resistance. YfmR addresses stalling at proline-rich motifs, while YkpA resolves stalling caused by charged motifs. This review draws on the work of Chadani, Boël, Fega, and our own studies to compare the structural and functional diversity of ABCF proteins across bacterial species. It highlights the key roles of antibiotic resistance/P site tRNA interaction motif domains in defining their specific functions and explores future research directions to further our understanding of ABCF proteins in translation control.

01 Jan 2025·Journal of Ethnopharmacology

Centipeda minima extracts and the active sesquiterpene lactones have therapeutic efficacy in non-small cell lung cancer by suppressing Skp2/p27 signaling pathway

Article

Author: Chen, Chu-Ying ; Cheng, Yong-Xian ; He, Wen-Da ; Liu, Yong-Qiang ; Zheng, Rou-Qiao ; Wu, Pei-En ; Pang, Yan-Chun ; Wang, Han-Chen ; Wu, Li-Chuan

ETHNOPHAMACOLOGICAL RELEVANCECentipeda minima (L.) A. Braun & Asch (C. minima) was applied to treat nasal allergy, headache, cough, and even nasopharyngeal carcinoma in traditional Chinese medicine. However, the underlying anticancer mechanisms of C. minima and its active components have not been systematically illustrated.AIM OF THE STUDYThe study aims to examine the therapeutic efficacy of the ethanol extract of C. minima (ECM) and its active components in non-small cell lung cancer (NSCLC) and illustrate the underlying mechanisms.MATERIALS AND METHODSThe main chemical components in the ethanol extract of C. minima (ECM) and the supercritical CO₂ fluid extract of C. minima (CM-SFE) were determined by using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). The antitumor effects of ECM and CM-SFE were examined by using NSCLC cell xenografts. The flow cytometry, cell colony formation, wound-healing, transwell assay, and Western blotting were conducted to investigate the anticancer properties of ECM, CM-SFE, and these sesquiterpene lactones that abundantly distributed in these extracts.RESULTSWe first determined that ECM contains high levels of sesquiterpene lactones. ECM can markedly induce cell cycle arrest and suppress migration and invasion of NSCLC cells. Mechanistically, ECM promoted proteasome-dependent degradation of Skp2 protein and induced the accumulation of its substrates p27; whereas Skp2 overexpression can attenuate the inhibitory effects of ECM on NSCLC proliferation and migration. Moreover, ECM at 200-600 mg/kg can significantly inhibit tumor growth and metastasis in A549-luciferase cell orthotopic xenografts by suppressing Skp2 expression. The sesquiterpene lactones that abundantly distributed in ECM, including 6-O-angeloylplenolin (6-OAP), arnicolide D (ArD) and arnicolide C (ArC), were also demonstrated to decrease Skp2 while increase p27 protein level, thereby significantly inducing cell cycle arrest and suppressing migration of NSCLC cells. Notably, CM-SFE, which mainly consisted of 6-OAP, ArD and ArC, exhibited much stronger anti-NSCLC activity than that of ECM in A549-luciferase cell orthotopic xenografts.CONCLUSIONOur results demonstrate that the active components in C. minima possesses potential anti-NSCLC activities by suppressing Skp2/p27 signaling pathway, and these active sesquiterpene lactones can be further developed as potent Skp2 inhibitor to treat NSCLC.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

ADI1

Basic Info

Related

Analysis