CTBP2

Last update 08 May 2025

Basic Info

Synonyms

C-terminal binding protein 2, C-terminal-binding protein 2, CTBP2

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Introduction

Isoform 2 probably acts as a scaffold for specialized synapses. Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

100 Clinical Results associated with CTBP2

100 Translational Medicine associated with CTBP2

0 Patents (Medical) associated with CTBP2

404

Literatures (Medical) associated with CTBP2

01 May 2025·Molecular Psychiatry

Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation

Article

Author: Herzog, Wolfgang ; Herpertz-Dahlmann, Beate ; Egberts, Karin ; Renner, Simone ; Mukherjee, Amrita ; Müller, Timo D ; Ehrlich, Stefan ; Shankhwar, Soni ; Rajcsanyi, Luisa Sophie ; Hinney, Anke ; Zheng, Yiran ; Marcus, Katrin ; Peters, Triinu ; Keyvani, Kathy ; Burghardt, Roland ; Föcker, Manuel ; Zipfel, Stephan ; May, Caroline ; Müller, Timo D. ; Jall, Sigrid ; Schmitz, Frank ; Seitz, Jochen ; Kurapati, Nirup Kumar ; Brandt, Matthäus ; de Zwaan, Martina ; Giuranna, Johanna ; Giel, Katrin

AbstractThe C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did a mutation analysis in CTBP2 by performing polymerase chain reactions with subsequent Sanger-sequencing to identify variants relevant for AN and body weight regulation and ensued functional studies. Analysis of the coding regions of CTBP2 in 462 female patients with AN (acute or recovered), 490 children and adolescents with severe obesity, 445 healthy-lean adult individuals and 168 healthy adult individuals with normal body weight detected 24 variants located in the specific exon of RIBEYE. In the initial analysis, three of these were rare non-synonymous variants (NSVs) detected heterozygously in patients with AN (p.Arg72Trp - rs146900874; p.Val289Met -rs375685611 and p.Gly362Arg - rs202010294). Four NSVs and one heterozygous frameshift variant were exclusively detected in children and adolescents with severe obesity (p.Pro53Ser - rs150867595; p.Gln175ArgfsTer45 - rs141864737; p.Leu310Val - rs769811964; p.Pro397Ala - rs76134089 and p.Pro402Ser - rs113477585). Ribeye mRNA was detected in mouse hypothalamus. No effect of fasting or overfeeding on murine hypothalamic Ribeye expression was determined. Yet, increased Ribeye expression was detected in hypothalami of leptin-treated Lepob/ob mice. This increase was not related to reduced food intake and leptin-induced weight loss. We detected rare and frequent variants in the RIBEYE specific exon in both patients with AN and in children and adolescents with severe obesity. Our data suggest RIBEYE as a relevant gene for weight regulation.

01 Mar 2025·International Journal of Biological Macromolecules

Proteomic analysis of the nonstructural protein 2-host protein interactome reveals a novel regulatory role of SH3 domain-containing kinase-binding protein 1 in porcine reproductive and respiratory syndrome virus replication and apoptosis

Article

Author: Chen, Ruiai ; Rong, Fang ; Lv, Yadi ; Wen, Lianghai ; Dai, Guo ; Liu, Yufu ; Luo, Qiong ; Liu, Ding Xiang

Virus-host protein interaction is critical for successful completion of viral replication cycles. As the largest nonstructural protein (NSP) of porcine reproductive and respiratory syndrome virus (PRRSV), NSP2 plays multiple and critical roles in viral replication, antiviral immunity, cellular tropism and virulence. An interactome of this protein with host proteins would be instrumental in full understanding of these multifunctional roles. In this study, we report the identification of 120 NSP2-interacting host proteins by co-immunoprecipitation coupled liquid chromatography mass spectrometry, via rescuing and utilizing a recombinant PRRSV expressing an HA-tagged NSP2. By comparing and subtracting with cells infected with parental virus, a comprehensive interactome was constructed. Bioinformatics analysis revealed that these host factors are mainly involved in translation regulation, metabolism, signal transduction and innate immunity signaling pathways. Selection of five host proteins (CtBP1, CtBP2, HSPA2, PPP1CA, SH3KBP1) for further verification and characterization confirmed their interactions with NSP2 and differential effects on PRRSV replication. Intriguingly, interaction of NSP2 and SH3KBP1 led to specific cleavage of SH3KBP1, antagonizing its pro-apoptotic activity. Taken together, this study provides overarching views on the NSP2-host interactome, paving a solid foundation for functional studies of host proteins in PRRSV biology and their potential as targets for novel therapeutics development.

31 Dec 2024·Epigenetics

Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis

Article

Author: Zhang, De-Kui ; Ma, Zeng-Hui ; Zhu, Hong-Wen ; Ma, Xue-Ni ; Cheng, Long ; Gou, Ling-Zhu

To investigate the clinical value of methylation levels of peripheral blood DDR1 and CtBP genes in evaluating the severity of acute pancreatitis (AP). Collect 90 blood samples from AP patients and healthy volunteers, and test methylation levels of SPINK1, STAT3, KIT, CFTR, DDR1, CtBP1, CtBP2 genes by bisulfite amplicon sequencing (BSAS). The gene methylation and clinical predictors of SAP early prediction were determined by univariate and multifactorial analysis, respectively. (1) The methylation level of CtBP1 gene and MCTSI score were independent predictors of SAP, with AUC values of 0.723 and 0.8895, respectively. (2) The methylation levels of DDR1, CtBP2, CFTR and SPINK1 genes were statistically significant in HC group vs AP group, HC group vs MAP group, and HC group vs SAP group. (3) The combined detection of CtBP1 gene methylation level and MCTSI score predicted the sensitivity, specificity, AUC, and 95%CI of SAP were 0.750, 0.957, 0.902, and 0.816-0.989, respectively. (1) The methylation level of CtBP1 gene in peripheral blood is an independent risk factor for predicting SAP and is a potentially good predictor of SAP, and the combined testing with the MCTSI score does not further significantly improve the early predictive value for SAP. (2) The methylation levels of DDR1, SPINK1, CtBP2, and CFTR genes were potential indicators for recognizing AP.

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CTBP2

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