NEO1

Last update 08 May 2025

Basic Info

Synonyms

HsT17534, IGDCC2, Immunoglobulin superfamily DCC subclass member 2

+ [5]

Introduction

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

100 Clinical Results associated with NEO1

100 Translational Medicine associated with NEO1

0 Patents (Medical) associated with NEO1

391

Literatures (Medical) associated with NEO1

01 May 2025·Poultry Science

Exploring the functional variations of key candidate genes affecting egg production by hypothalamic-pituitary-ovarian axis in chickens

Article

Author: Liu, Xiaojun ; Dong, Jiajia ; Kang, Xiangtao ; Wei, Guanghui ; Zhu, Yiqian ; Wang, Dandan ; Zhi, Yihao

Potential genetic variants associated with chicken egg production traits have been extensively identified, most of which are located in the non-coding regions of the genome. However, which functional variants really drive the egg-laying phenotype change remain elusive. In the present study, by integrating the previously screened egg-laying related candidate genetic variants, transcriptome data derived from 16 high- and low-yield Gushi chickens, and epigenomic analyses, 22 potential functional variants (PFVs) were systematically identified. These PFVs potentially drive the differences in egg production phenotypes by affecting the expression of 10 egg-laying related key candidate genes in the hypothalamus (ZNF804B, DPP10, NEO1 and GABRG1), pituitary (DPP10 and GNG7), and ovary (PHIP, OSTN, GADD45B, NFXL1 and ADAMTS17). Subsequently, the regulatory activity and function of one PFV, chr3:79510218A>T, located in the third intron of the pleckstrin homology domain interacting protein gene (PHIP), were investigated in chicken ovarian granulosa cells. Association analysis confirmed the significant association of chr3:79510218A>T with egg number from 21 to 43 week of age in Gushi chicken (P = 0.0022) and Guangxi Yao chicken (P = 0.0388), as well as with ovarian PHIP expression levels (P = 0.0010). Functional analysis indicated that the T allele of chr3:79510218A>T enhanced the transcriptional activity and upregulated PHIP expression in vitro by binding transcription factor forkhead box I1 (FOXI1). Furthermore, the knockdown of PHIP led to the inhibition of ovarian granulosa cell proliferation and a reduction in the synthesis and secretion of progesterone (PROG) hormones. Collectively, this study unveil the egg-laying related functional variants and illustrate a potential genetic regulation mechanism, and will help accelerate the molecular design breeding process of chicken egg production.

01 Apr 2025·Tissue and Cell

Netrin-1: Key insights in neural development and disorders

Review

Author: Nabeel Mustafa, Anfal ; Ballal, Suhas ; Verma, Rajni ; Salih Mahdi, Morug ; Kumar, M Ravi ; Ali Al-Nuaimi, Ali M ; Kadhim A Al-Hussein, Rouaida ; Adil, Mohaned ; Chahar, Mamata ; Jasem Jawad, Mahmood

Netrin-1, an essential extracellular protein, has gained significant attention due to its pivotal role in guiding axon and cell migration during embryonic development. The fundamental significance of netrin-1 in developmental biology is reflected in its high conservation across different species as a part of the netrin family. The bifunctional nature of netrin-1 demonstrates its functional versatility, as it can function as either a repellent or an attractant according to the context and the expressed receptors on the target cells including the deleted in colorectal cancer (DCC), the uncoordinated-5 (UNC5), DSCAM, Neogenin-1, Adenosine A2b and Draxin receptors. By directing axonal growth cones toward the appropriate targets, netrin-1 is a critical actor in the formation of the intricate architecture of the nervous system. Netrin-1 is believed to be involved in additional biological and pathological processes in addition to its traditional function in neural development. The behavior of a diverse array of cell types is influenced by controlling cell adhesion and movement, which is impacted by netrin-1. It is a molecule of interest in both developmental biology and clinical research because of its involvement in angiogenesis, tumorigenesis, inflammation, and tissue regeneration, as confirmed by recent studies. The therapeutic capability of netrin-1 in disorders such as cancer, neurodegenerative disorders, and cardiovascular diseases warrants significant attention.

01 Apr 2025·Advanced Science

(Apo)Lipoprotein Profiling with Multi‐Omics Analysis Identified Medium‐HDL‐Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease

Article

Author: Liu, Ling ; Wang, Sihan ; Cai, Hao ; Li, Yingmei ; Wu, Qingqing ; Huang, Yacan ; Gao, Mingjing ; Zhang, Xiaogang ; Qiu, Gaokun

AbstractIdentification of (apo)lipoprotein subclasses causally underpinning atherosclerosis may lead to identification of novel drug targets for treatment of atherosclerotic cardiovascular disease (ASCVD). In this study, observational and genetic associations between (apo)lipoprotein profile and carotid intima‐media thickness‐assessed atherosclerosis, and risks of coronary artery disease (CAD) and ischemic stroke (IS) are assessed, using data from the UK Biobank study, with further exploration of potential drug target for these two ASCVD subtypes through multi‐omics analysis integrating genetic, transcriptomic, and proteomic data. Cholesteryl ester content in medium high‐density lipoprotein causally protective of atherosclerosis is identified, plus a target gene, PSRC1, with therapeutic potential for CAD, but not IS, supported by consistent evidence from multi‐omics layers of data, which also reveals that such therapeutic potential may be through downregulation of circulating proteins including TRP1, GRNs, and Pla2g12b, and upregulation of Neo1. The results provide strong evidence as well as mechanistic clues of PSRC1’s therapeutic potential for CAD.

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