Last update 01 Nov 2024

Rv0288

Last update 01 Nov 2024

Basic Info

Synonyms

TB10.4, Tuberculosis 10.4

Introduction-

Drugs associated with Rv0288

Tri:ChAd:TB

Target

Antigen 85A x RpfB x Rv0288

Mechanism

Antigen 85A inhibitors [+2]

Active Org.

McMaster University

Originator Org.

McMaster University

Active Indication

Tuberculosis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Rv0288

100 Translational Medicine associated with Rv0288

0 Patents (Medical) associated with Rv0288

128

Literatures (Medical) associated with Rv0288

01 Dec 2023·Journal of Genetic Engineering and Biotechnology

Phylogenetic analysis of prospective M. bovis antigens with the aim of developing candidate vaccines for bovine tuberculosis

Article

Author: Zakarya, Kunsulu ; Barakbayev, Kainar ; Abay, Zhandos ; Tokkarina, Gaukhar ; Abduraimov, Yergali ; Syrym, Nazym ; Kalimolda, Elina ; Shayakhmetov, Yeraly ; Sadikalieva, Sandugash ; Absatova, Zharkinay ; Yespembetov, Bolat ; Issabek, Aisha ; Kopeyev, Syrym ; Nurpeisova, Ainur ; Jekebekov, Kuanish ; Shorayeva, Kamshat ; Moldagulova, Sabina ; Sarmykova, Makpal ; Omurtay, Alisher ; Kassenov, Markhabat

AbstractBackgroundBovine Tuberculosis is a respiratory disease caused by the pathogen Mycobacterium bovis (M. bovis) that infects cattle. Though rare, this disease can also affect humans, as well as domestic and wild animals, making it a serious concern. Therefore, searching for alternative and new vaccines with high efficiency and safety is the main goal in bovine tuberculosis prophylaxis. New vaccines, known as vector vaccines, have the potential to become safe and effective alternatives to the traditional BCG vaccine. In this study, two major immunodominant proteins of M. bovis Esat-6 and TB10.4 were utilized to create a vector vaccine for bovine tuberculosis.MethodsThe Esat-6 and TB10.4 genes were amplified by PCR. The amplified and purified PCR products were sequenced by the Sanger method. Assembly and multiple alignments of amplicon nucleotides were carried out in the MEGA 11 software.ResultTwo genes of the local strain 0078-M. bovis-8/RIBSP were sequenced. The nucleotide sequences were deposited in the GenBank database. Comparative analysis of the nucleotide sequences of the ESAT-6 and TB10.4 genes established 100% identity of the compared strains of Mycobacterium.ConclusionThrough the use of phylogenetic analysis, it has been confirmed that the amplified genes are related to the mycobacteria genus. This discovery allows the development of a vector vaccine against bovine tuberculosis utilising these genes.

04 Jul 2023·Vaccines

Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis.

Article

Author: Yespembetov, Bolat ; Yoo, Han Sang ; Abay, Zhandos ; Abduraimov, Yergali ; Absatova, Zharkinay ; Sarmykova, Makhpal ; Sadikaliyeva, Sandugash ; Abitayev, Ruslan ; Kalimolda, Elina ; Nurpeisova, Ainur ; Shorayeva, Kamshat ; Moldagulova, Sabina ; Jekebekov, Kuanysh ; Tokkarina, Gaukhar ; Kassenov, Markhabat ; Zakarya, Kunsulu ; Syrym, Nazym

This study presents the results of a survey of the safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with the NS1 mutation and expressing M. bovis protective antigens ESAT-6 and TB10.4. We vaccinated Balb/c outbred mice two times at 21 days apart. Our experimental design includes mice immunised with the candidate vaccine with or without adjuvant 15% Montanide Gel. The candidate vaccine's safety was determined by biometric analysis, and protective efficacy was assessed by bacteriological and histological experiments following a virulent M. bovis-8 strain challenge. Our data indicated that the adjuvant-free version of the vaccine ensured complete protection from the M. bovis-8 infection in mice.

15 May 2023·Journal of immunology (Baltimore, Md. : 1950)

High Bacillary Burden and the ESX-1 Type VII Secretion System Promote MHC Class I Presentation by Mycobacterium tuberculosis-Infected Macrophages to CD8 T Cells.

Article

Author: Sassetti, Christopher M ; Behar, Samuel M ; Mott, Daniel ; Baer, Christina ; Papavinasasundaram, Kadamba ; Yang, Jason

We used a mouse model to study how Mycobacterium tuberculosis subverts host defenses to persist in macrophages despite immune pressure. CD4 T cells can recognize macrophages infected with a single bacillus in vitro. Under identical conditions, CD8 T cells inefficiently recognize infected macrophages and fail to restrict M. tuberculosis growth, although they can inhibit M. tuberculosis growth during high-burden intracellular infection. We show that high intracellular M. tuberculosis numbers cause macrophage death, leading other macrophages to scavenge cellular debris and cross-present the TB10.4 Ag to CD8 T cells. Presentation by infected macrophages requires M. tuberculosis to have a functional ESX-1 type VII secretion system. These data indicate that phagosomal membrane damage and cell death promote MHC class I presentation of the immunodominant Ag TB10.4 by macrophages. Although this mode of Ag presentation stimulates cytokine production that we presume would be host beneficial, killing of uninfected cells could worsen immunopathology. We suggest that shifting the focus of CD8 T cell recognition to uninfected macrophages would limit the interaction of CD8 T cells with infected macrophages and impair CD8 T cell-mediated resolution of tuberculosis.

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Rv0288

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