Last update 01 Nov 2024

frc

Last update 01 Nov 2024

Basic Info

Synonyms-

Introduction-

Drugs associated with frc

SYNB-8802

Target

frc x oxdC x oxlT x scaaE3

Mechanism

frc stimulants [+5]

Active Org.

Synlogic, Inc.

Originator Org.

Synlogic, Inc.

Active Indication

Hyperoxaluria [+1]

Inactive Indication-

Drug Highest PhasePhase 1

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with frc

NCT05377112 / CompletedEarly Phase 1

A Double-Blind, Randomized, Placebo-controlled Study to Assess the Safety, Tolerability, and Pharmacodynamics of SYNB8802v1 in Subjects With History of Gastric Bypass Surgery or Short-bowel Syndrome

Study SYNB8802-CP-002 is designed to assess safety, tolerability, and oxalate lowering, in subjects with a history of gastric bypass surgery or short-bowel syndrome. In addition, this study will explore other PD effects relative to baseline as well as predictors of efficacy and tolerability.

Start Date29 Mar 2022

Sponsor / Collaborator

Synlogic, Inc.

NCT04629170 / CompletedPhase 1

A Double-Blind, Randomized, Placebo-Controlled Study to Assess the Safety, Tolerability, and Pharmacodynamics of SYNB8802 in Healthy Volunteers and in Patients With Enteric Hyperoxaluria

This Phase 1a/b, first-in-human, multiple dose-escalation, randomized, double-blinded, placebo-controlled study is evaluating SYNB8802 in healthy volunteers (HV) and subjects diagnosed with enteric hyperoxaluria (EH). Eligible subjects receive investigational product (IP) and undergo safety monitoring, evaluations, and subsequent follow-up after IP administration.
In Part 2, all evaluations and assessments throughout this study may be conducted either at the clinical site or by a home healthcare professional at an alternative location (e.g., EH patient's home, hotel).

Start Date04 Nov 2020

Sponsor / Collaborator

Synlogic, Inc.

100 Clinical Results associated with frc

100 Translational Medicine associated with frc

0 Patents (Medical) associated with frc

175

Literatures (Medical) associated with frc

01 Jul 2024·iScience

Human lymph node fibroblastic reticular cells maintain heterogeneous characteristics in culture

Article

Author: Mikula, Aleksandra M ; de Winde, Charlotte M ; Roet, Janna E G ; van der Laan, Luc J W ; Panocha, Daphne ; de Kok, Michael ; Roest, Henk P ; Morrison, Andrew I ; Mebius, Reina E

Fibroblastic reticular cells (FRCs) are mesenchymal stromal cells in human lymph nodes (LNs) playing a pivotal role in adaptive immunity. Several FRC subsets have been identified, yet it remains to be elucidated if their heterogeneity is maintained upon culture. Here, we established a protocol to preserve and culture FRCs from human LNs and characterized their phenotypic profile in fresh LN suspensions and upon culture using multispectral flow cytometry. We found nine FRC subsets in fresh human LNs, independent of donor, of which four persisted in culture throughout several passages. Interestingly, the historically FRC-defining marker podoplanin (PDPN) was not present on all FRC subsets. Therefore, we propose that CD45^negCD31^neg human FRCs are not restricted by PDPN expression, as we found CD90, BST1, and CD146/MCAM to be more widely expressed. Together, our data provide insight into FRC heterogeneity in human LNs, enabling further investigation into the function of individual FRC subsets.

01 Jun 2024·Sleep and Breathing

Ultrasonographic changes and impact factors of diaphragmatic function in patients with obstructive sleep apnea–hypopnea syndrome

Article

Author: Chen, Rui ; Wang, Zhijun ; Zhang, Yingchun ; Li, Jing

PURPOSEDiaphragmatic impairment has been reported in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. However, the risk factors of diaphragmatic dysfunction are unclear. This study was conducted to evaluate the diaphragmatic function and to investigate impact factors of ultrasonographic changes of the diaphragm in OSAHS patients.METHODSThis cross-sectional study recruited 150 snoring patients. All patients were divided into the control group (AHI < 5/h, n = 20), the mild-to-moderate OSAHS group (5/h ≤ AHI ≤ 30/h, n = 61), and the severe OSAHS group (AHI > 30/h, n = 69). Diaphragmatic thickness at function residual capacity (T_FRC) and total lung capacity (T_TLC) were measured by two-dimensional ultrasound, and the diaphragmatic excursion during tidal and deep breath was measured by M-mode ultrasound. The diaphragmatic thickening fraction (TF) was calculated. Spearman analysis and multiple linear stepwise regression analysis were conducted to analyze the impact factors of diaphragmatic function.RESULTST_FRC in the control group, mild-to-moderate OSAHS group, and severe OSAHS group was 1.23 (1.10, 1.39) mm, 1.60 (1.43, 1.85) mm, and 1.90 (1.70, 2.25) mm; T_TLC was 2.75 (2.53, 2.93) mm, 3.25 (2.90, 3.55) mm, and 3.60 (3.33, 3.90) mm, and TF was 119.23% (102.94, 155.97), 96.55% (74.34, 119.11), and 85.29% (60.68,101.22). There were across-group significant differences in T_FRC, T_TLC, and TF (P < 0.05). The oxygen desaturation index was the influencing factor of T_FRC, T_TLC, and TF (P < 0.05).CONCLUSIONThe diaphragm is thickened and diaphragmatic contractility is decreased in OSAHS patients. Nocturnal intermittent hypoxia is a risk factor for diaphragmatic hypertrophy and impaired diaphragmatic contractility.

01 Apr 2024·Immunology & Cell Biology

The transcription factor SpiB regulates the fibroblastic reticular cell network and CD8⁺ T‐cell responses in lymph nodes

Article

Author: Alexandre, Yannick O ; Mueller, Scott N ; Horsnell, Harry L ; Cao, Wang Hj ; Belz, Gabrielle T

AbstractFibroblastic reticular cells (FRCs) construct microanatomical niches that support lymph node (LN) homeostasis and coordination of immune responses. Transcription factors regulating the functionality of FRCs remain poorly understood. Here, we investigated the role of the transcription factor SpiB that is expressed in LN FRCs. Conditional ablation of SpiB in FRCs impaired the FRC network in the T‐cell zone of LNs, leading to reduced numbers of FRCs and altered homeostatic functions including reduced CCL21 and interleukin‐7 expression. The size and cellularity of LNs remained intact in the absence of SpiB but the space between the reticular network increased, indicating that although FRCs were reduced in number they stretched to maintain network integrity. Following virus infection, antiviral CD8+ T‐cell responses were impaired, suggesting a role for SpiB expression in FRCs in orchestrating immune responses. Together, our findings reveal a new role for SpiB as an important regulator of FRC functions and immunity in LNs.

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