CCNY

Last update 23 Jan 2025

Basic Info

Synonyms

C10orf9, CBCP1, CCNY

+ [7]

Introduction

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.

100 Clinical Results associated with CCNY

100 Translational Medicine associated with CCNY

0 Patents (Medical) associated with CCNY

152

Literatures (Medical) associated with CCNY

11 Jan 2024·Microbiology Spectrum

Predominant transmission of KPC-2 carbapenemase in Germany by a unique IncN plasmid variant harboring a novel non-transposable element (NTE _KPC -Y)

Article

Author: Heinmüller, Petra ; Hauri, Anja M. ; Pfennigwerth, Niels ; Bunk, Boyke ; Exner, Martin ; Ghosh, Hiren ; Imirzalioglu, Can ; Kaase, Martin ; Falgenhauer, Linda ; Janssen, Stefan ; Falgenhauer, Jane ; Overmann, Jörg ; Domann, Eugen ; Yao, Yancheng ; Goesmann, Alexander ; Chakraborty, Trinad ; Gatermann, Sören ; Spröer, Cathrin ; Rezazadeh, Yalda

ABSTRACT Carbapenemase-producing Enterobacterales (CPE) pose a major public health threat. Despite active infection prevention efforts, the incidence of KPC-2 carbapenemase-producing Enterobacterales (KPC2-CPE) continues to increase worldwide. In this study, we performed genome sequencing of 135 KPC2-CPE isolates obtained from multiple sources (clinical, hospital environments, and surface water) in Germany between 2013 and 2019 and analyzed them for epidemiological clues regarding transmission. For 92% (124/135) of all isolates, which comprised 14 different species such as Klebsiella, Escherichia, Citrobacter, Enterobacter, Raoultella, and Serratia , KPC-2 was present on an IncN[pMLST15] plasmid. All plasmids carried a novel non-Tn 4401 -element harboring an aac (3)-IId-blaTEM-1B - blaKPC-2 –cassette (designated NTE KPC -Y) that was co-transferred with an adjacent region carrying 12 further antibiotic resistance genes. Identical plasmids were also detected in KPC2-CPE isolates from environmental samples. These plasmids were remarkably stable and were maintained in individual patients colonized with KPC-2 CPEs over a long-term period (>1 year). Thus, a predominant broad host range signature IncN[pMLST15] plasmid mediates transmission of both KPC-2 and associated multiple antimicrobial drug resistance genes in Germany. These data underline the need for in-depth characterization of plasmid carriers of CPE in surveillance and outbreak studies as well as in microbiomes from patients and the environment to identify hidden transmission reservoirs. This information will be essential for the development and implementation of effective infection control and prevention measures to disrupt dissemination of KPC2- CPEs in healthcare and associated environmental settings. IMPORTANCE Current infection control protocols assume that the spread of KPC-2 carbapenemase-producing Enterobacterales ( KPC2-CPE) by detected carriers to other in-house patients is through clonal transmission and can be restricted by implementing containment measures. We examined the presence of the blaKPC-2 gene in different genera and species of Enterobacterales isolated from humans at different hospitals and surface waters between 2013 and 2019 in Germany. We found that a single IncN[pMLST15] plasmid carrying the blaKPC-2 gene on a novel non-Tn 4401 -element (NTE KPC -Y), flanked by an adjacent region encoding 12 other antibiotic resistance genes, was uniquely present in multiple species of KPC2-CPE isolates. These findings demonstrate the selective impact of specific IncN plasmids as major drivers of carbapenemase dissemination and suggest “plasmid-based endemicity” for KPC2-CPE. Studies on the dynamics of plasmid-based KPC2-CPE transmission and its presence in persistent reservoirs need to be urgently considered to implement effective surveillance and prevention measures in healthcare institutions.

01 Aug 2023·Biomedicine & Pharmacotherapy

The roles, molecular interactions, and therapeutic value of CDK16 in human cancers

Review

Author: Liu, Ruiqi ; Li, Shuang ; Zhang, Haibo ; Yao, Weiping ; Wang, Xiao ; Lu, Yanwei ; Xia, Wenjie ; Guo, Haiwei ; Liang, Xiaodong

Cyclin-dependent kinase 16 (CDK16) is an orphan "cyclin-dependent kinase" (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferation, metastasis, and autophagy. Human CDK16 is located on chromosome Xp11.3 and is related to X-linked congenital diseases. CDK16 is commonly expressed in mammalian tissues and may act as an oncoprotein. It is a PCTAIRE kinase in which Cyclin Y or its homologue, Cyclin Y-like 1, regulates activity by binding to the N- and C- terminal regions of CDK16. CDK16 plays a vital role in various cancers, including lung cancer, prostate cancer, breast cancer, malignant melanoma, and hepatocellular carcinoma. CDK16 is a promising biomarker for cancer diagnosis and prognosis. In this review, we summarized and discussed the roles and mechanisms of CDK16 in human cancers.

18 Apr 2023·Cell Cycle

The role of cyclin Y in normal and pathological cells

Review

Author: Krajewski, Adrian ; Mikołajczyk, Klaudia ; Opacka, Aleksandra ; Żuryń, Agnieszka

The family protein of cyclins, as well as cyclin-dependent kinases (CDKs) cooperating with them, are broadly researched, as a matter of their dysfunction may lead to tumor transformation. Cyclins are defined as key regulators that have a controlling function of the mammalian nuclear cell divides. Cyclin Y (CCNY) is a recently characterized member of the cyclin family and was first identified from the human testis cDNA library. It is an actin-binding protein acting through decreased actin dynamics at a steady state and during glycine-induced long-term potentiation (LTP) and involves the inhibition of cofilin activation. What is more, CCNY is a positive regulatory subunit of the CDK14/PFTK1 complexes affected by the activation of the Wnt signaling pathway in the G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6. The expression of CCNY has been significantly mentioned within the cell migration and invasion activity both in vivo and in vitro. The aim of this review is evaluation of the expression of CCNY in the physiology processes and compare the expression of this protein in cancer cells, taking into account the impact of the level of expression on tumor progression.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

CCNY

Basic Info

Related

Analysis