Last update 23 Jan 2025

CEMIP2

Basic Info

Synonyms
cell migration inducing hyaluronidase 2, Cell migration-inducing hyaluronidase 2, Cell surface hyaluronidase
+ [4]
Introduction
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).

Related

1
Drugs associated with CEMIP2
CN114032236
Patent Mining
Target
CEMIP2
Mechanism-
Active Org.
Nantong Tumor Hospital
Originator Org.
Nantong Tumor Hospital
Active Indication
Gastrointestinal Neoplasms
Inactive Indication-
Drug Highest PhaseDiscovery
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with CEMIP2
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100 Translational Medicine associated with CEMIP2
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0 Patents (Medical) associated with CEMIP2
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73
Literatures (Medical) associated with CEMIP2
01 Mar 2025International Journal of Biological Macromolecules
Retraction notice to “Aptamer/doxorubicin-conjugated nanoparticles target membranous CEMIP2 in colorectal cancer” [International Journal of Biological Macromolecules 245 (2023) 125510]
01 Mar 2025International Journal of Biological Macromolecules
Retraction notice to “Corrigendum to ‘Aptamer/doxorubicin-conjugated nanoparticles target membranous CEMIP2 in colorectal cancer’ [International Journal of Biological Macromolecules 248 (2023) 125782]”
01 Dec 2024Molecular Biology Reports
TMEM2 suppresses TLR3-mediated IFN-β/ISG56/CXCL10 expression in BEAS-2B bronchial epithelial cells

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