ETV5

Last update 08 May 2025

Basic Info

Synonyms

ERM, ETS translocation variant 5, ETS variant transcription factor 5

+ [2]

Introduction

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.

100 Clinical Results associated with ETV5

100 Translational Medicine associated with ETV5

0 Patents (Medical) associated with ETV5

1,798

Literatures (Medical) associated with ETV5

01 Apr 2025·Journal of Cellular and Molecular Medicine

PEA3 Transcription Factors, Role in Invasion, Proliferation and Radioresistance of Glioblastoma Stem Cells

Article

Author: Seva, Catherine ; Nicaise, Yvan ; Cohen‐Jonathan‐Moyal, Elizabeth ; Delmas, Caroline

ABSTRACTThe presence of glioblastoma stem cells (GSCs), known for their high invasiveness and resistance to radiation, is one of the reasons for systematic recurrence. It is therefore important to understand the resistance mechanisms of these cells to optimise therapies. We focused on the PEA3 family of transcription factors, ETV1, ETV4 and ETV5, in patient‐derived GSCs. We demonstrate that ETV1 is over‐expressed in high invasive GSCs. In 3D invasion assays, inhibiting ETV1 expression using specific siRNAs significantly reduces cell invasion. Furthermore, we show a significant correlation between ETV1 and ZEB1, a major driver of invasion. Blocking ETV1 decreases ZEB1 expression in GSCs. The study also demonstrates the essential role of ETV1, ETV4 and ETV5 in the radioresistance of GSCs and their ability to form neurospheres. Using specific siRNAs to inhibit the expression of these transcription factors led to an increased sensitivity of GSCs to radiation and a decrease in both the number and size of neurospheres. These findings suggest that PEA3 transcription factors play a major role in GSCs aggressiveness by regulating invasion, radioresistance and the ability to form neurospheres.Trial Registration: Registry and the Registration N° of the study/trial: 12TETE01, ID‐RCB No. 2012‐A00585‐38, approval Date: May 7, 2012

01 Apr 2025·Pathology - Research and Practice

Unveiling the multifaceted roles of long non-coding RNA CTBP1-DT in human diseases: Special attention to its microprotein-encoding potential

Review

Author: Yang, Jingjie

C-terminal binding protein 1 divergent transcript (CTBP1-DT) is a novel long non-coding RNA (lncRNA) located on human chromosome 4p16.3. Numerous studies have shown that CTBP1-DT plays a critical regulatory role in various human malignancies and non-malignant diseases. In several cancers, the expression of CTBP1-DT is upregulated, closely associated with the risk of 12 types of cancer, and strongly correlated with the clinical pathological features and poor prognosis of 10 of these cancers. Mechanistically, CTBP1-DT is stimulated by the transcription factors ETV5 and Sp1, or methylated by YTHDC1. By competitively inhibiting 12 microRNAs, it activates 3 signaling pathways that influence malignant behaviors of tumor cells, including proliferation, apoptosis, cell cycle arrest, migration, invasion, immune evasion, and chemoresistance. Importantly, it also encodes the microprotein DNA damage up-regulated protein (DDUP), which mediates cisplatin resistance through sustained response to DNA damage signals. Furthermore, CTBP1-DT has been implicated in the progression of non-malignant diseases such as diabetes and related conditions, cardiovascular diseases, and osteoarthritis. This review summarizes the latest research on the RNA and protein functions of CTBP1-DT in human diseases, outlines various molecular regulatory networks centered around CTBP1-DT, and discusses the opportunities and challenges of its clinical applications.

27 Mar 2025·Open Forum Infectious Diseases

Pandemic Social Distancing and Declines in Nasopharyngeal Carriage of Pneumococcus and Related Antimicrobial-Resistant Genes: Evidence From Household-Based Cohort Studies in Lima, Peru

Article

Author: Charnogursky, Cara E ; Jones, Angela ; Ochoa, Mayra ; Chen, Qingxia ; Rios, Stefano ; Lanata, Claudio F ; Chen, Huiding ; Gil, Ana I ; Peña, Bia ; Flores, Omar ; Beeri, Karen ; Howard, Leigh M ; Cornejo, Rubelio ; Ecker, Lucie ; Grijalva, Carlos G

AbstractBackgroundPeru implemented restrictive social distancing policies during the COVID-19 pandemic. Few studies have examined patterns of nasopharyngeal pneumococcal carriage and related antimicrobial-resistant genes (ARGs), particularly in community-based settings with intense social distancing policies.MethodsNasopharyngeal swabs were systematically obtained weekly from children and adults enrolled in 2 household-based prospective cohorts in Lima, Peru: prepandemic (2019–2020) and pandemic (2020–2021). Selected samples underwent sequencing-based detection of Streptococcus pneumoniae and related ARGs. We compared detections of pneumococcus and erm genes between cohorts during the same 7 epidemiologic weeks in 2020 and 2021 while accounting for relevant covariates and household clustering by mixed effects logistic regression models.ResultsAn overall 663 specimens from 114 individuals were included: 407 and 256 samples from the prepandemic and pandemic cohorts, respectively. Carriage of pneumococcus was lower in the pandemic cohort (3.5%) as compared with the prepandemic cohort (23.6%; adjusted odds ratio, 0.09; 95% CI, .02–.32). Similarly, erm gene carriage was lower in the pandemic cohort (28.1%) as compared with the prepandemic cohort (58.7%; adjusted odds ratio, 0.21; 95% CI, .10–.46).ConclusionsWe observed a substantial reduction in the carriage of S pneumoniae and related ARGs in community-dwelling individuals during a pandemic period with intense social distancing in Lima, Peru.

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