GLUD2

Last update 08 May 2025

Basic Info

Synonyms

GDH 2, GLUD2, GLUDP1

+ [2]

Introduction

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.

100 Clinical Results associated with GLUD2

100 Translational Medicine associated with GLUD2

0 Patents (Medical) associated with GLUD2

252

Literatures (Medical) associated with GLUD2

01 Jul 2025·Journal of Hazardous Materials

Impact of ibuprofen on microalgal-bacterial granular sludge: Metabolic pathways, functional gene responses and biodegradation mechanisms

Article

Author: Zhang, Xiaoyuan ; Liu, Yu ; Ji, Bin ; Liang, Hua ; Chen, Bingheng ; Li, Anjie

Ibuprofen (IBU), a persistent and toxic emerging pollutant widely used as a nonsteroidal anti-inflammatory drug, poses significant challenges for wastewater treatment. This study investigates the effects of IBU on the microalgal-bacterial granular sludge (MBGS) process, a promising approach for wastewater treatment. Results indicate that MBGS can enhance its resilience by secreting more extracellular polymeric substances for effective adsorption. Proteobacteria displayed high adaptability to IBU, while the abundance of Cyanobacteria exhibited considerable fluctuations, leading to cellular structural deformation and a decrease in abundance under 1 mg/L IBU stress. The abundance of functional genes involved in nitrogen and organic matter metabolism, including GDH2, ACSS1_2, and mqo, was significantly influenced by IBU stress, thereby affecting overall system performance. Additionally, several degradation by-products of IBU which have lower toxicity were identified, suggesting the effective biodegradation within the MBGS system. Structural equation modeling indicated that IBU exerted a greater negative impact on microalgae than on bacteria. This study confirms the adaptability of the MBGS system to wastewater containing IBU, highlighting its promising application in treating wastewater with emerging contaminants.

01 Apr 2025·Plant Molecular Biology

A large-scale gene co-expression network analysis reveals Glutamate Dehydrogenase 2 (GhGDH2_D03) as a hub regulator of salt and salt-alkali tolerance in cotton

Article

Author: Hu, Guanjing ; Gao, Zhan ; Zhang, Xianliang ; Xiong, Xianpeng ; Chen, Xiugui ; Ma, Xiongfeng ; Ye, Wuwei ; Hao, Rui ; Wang, Xingxing

Salt stress and salt-alkali stress significantly inhibit the normal growth and development of plants. Understanding the molecular mechanisms of cotton responses to these stresses is crucial for improve yield and fiber quality. In this study, we conducted a comprehensive analysis of the transcriptome dynamics under salt and salt-alkali stress conditions, utilizing 234 RNA-seq datasets compiled from 11 previous studies. After systematic evaluation and correction for batch effects, we observed that root transcriptomes clustered more consistently than leaf transcriptomes across stress treatment and time points. Weighted gene co-expression network analysis (WGCNA) on 123 root transcriptomes identified three key modules, with their hub genes significantly associated with salt and salt-alkali tolerance. Virus-induced gene silencing assay and RNA-seq analysis indicated that GhGDH2_D03 (Gohir.D03G104800), a module hub gene encoding Glutamate Dehydrogenase 2, positively regulates salt and salt-alkali tolerance in cotton by modulating multiple signaling pathways and metabolic processes, including the ethylene signaling pathway. This study underscores the pivotal role of GhGDH2_D03 in conferring tolerance to salt and salt-alkali stress, in addition to its previous reported involvement in biotic stress defense, providing valuable insights and genetic resources for cotton breeding.

04 Dec 2024·Journal of Experimental Botany

Natural variation in the adjustment of primary metabolism determines ammonium tolerance in the model grass Brachypodium distachyon

Article

Author: Cassan, Cédric ; Urmeneta, Leyre ; Gibon, Yves ; Vega-Mas, Izargi ; Urbano-Gámez, Jose Alberto ; Poucet, Théo ; Catalán, Pilar ; De la Peña, Marlon ; Montardit-Tarda, Francesc ; Marino, Daniel ; Gonzalez-Moro, M Begoña ; Igartua, Ernesto

AbstractNitrogen (N) fertilization is essential to maximize crop production. However, around half of the applied N is lost to the environment, causing water and air pollution and contributing to climate change. Understanding the natural genetic and metabolic basis underlying plants N use efficiency is of great interest to attain an agriculture with less N demand and thus more sustainable. The study of ammonium (NH4+) nutrition is of particular interest, because it mitigates N losses due to nitrate (NO3–) leaching or denitrification. In this work, we studied Brachypodium distachyon, the model plant for C3 grasses, grown with NH4+ or NO3– supply. We performed gene expression analysis in the root of the B. distachyon reference accession Bd21 and examined the phenotypic variation across 52 natural accessions through analyzing plant growth and a panel of 22 metabolic traits in leaf and root. We found that the adjustment of primary metabolism to NH4+ nutrition is essential for the natural variation of NH4+ tolerance, notably involving NH4+ assimilation and phosphoenolpyruvate carboxylase (PEPC) activity. Additionally, genome-wide association studies (GWAS) indicated several loci associated with B. distachyon growth and metabolic adaptation to NH4+ nutrition. We found that the GDH2 gene was associated with the induction of root glutamate dehydrogenase activity under NH4+ nutrition and that two genes encoding malic enzyme were associated with leaf PEPC activity. Altogether, our work underlines the value of natural variation and the key role of primary metabolism to improve NH4+ tolerance.

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GLUD2

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