APOOP1

Last update 08 May 2025

Basic Info

Synonyms

apolipoprotein O pseudogene 1, APOOP1

Introduction-

100 Clinical Results associated with APOOP1

100 Translational Medicine associated with APOOP1

0 Patents (Medical) associated with APOOP1

Literatures (Medical) associated with APOOP1

25 Sep 2018·CirculationQ1 · MEDICINE

An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels

Q1 · MEDICINE

Article

Author: Correa, Adolfo ; Penchev, Sara ; McFarland, Sean ; Taylor, Kent ; Mathai, Susan ; Heather, Ochs-Balcom ; Ashley-Koch, Allison ; de Andrade, Mariza ; Bowler, Russel ; Gladwin, Mark ; Kang, Hyun Min ; Rice, Ken ; Lee, Seunggeun ; Farber, Charles ; Eaton, Charles ; Hernandez, Ryan ; Fullerton, Malia ; Hall, Michael ; Ruuska, Sarah ; Hui-Heng Sheu, Wayne ; McGarvey, Stephen ; Lunetta, Kathryn ; Stilp, Adrienne ; Kelly, Shannon ; Lange, Christoph ; Davis, Colleen ; Darbar, Dawood ; Mikulla, Julie ; Ekunwe, Lynette ; Li, Yun ; Mathias, Rasika ; Farnam, Leanna ; Chen, Bo-Juen ; O'Connor, Tim ; Konkle, Barbara ; Chang, Christy ; Ament, Seth ; North, Kari ; Szpiro, Adam ; Germer, Soren ; Martin, Lisa ; Johnson, Andrew ; Harris, Daniel ; Sotoodehnia, Nona ; Kenny, Eimear ; Cupples, L. Adrienne ; McFarland, Rebecca ; Hwu, Chii Min ; Barron-Casella, Emily ; Peralta, Juan Manuel ; Johnsen, Jill ; Ellinor, Patrick ; Pollin, Toni ; Rice, Kenneth ; Durda, Peter ; Jain, Deepti ; Levy, Dan ; Regan, Elizabeth ; Casella, James ; Make, Barry ; Raffield, Laura ; Broome, Jai ; DeMeo, Dawn ; Rotter, Jerome ; Arking, Dan ; Damcott, Coleen ; Abe, Namiko ; Guan, Yue ; Beaty, Terri ; Luo, James ; Assimes, Tim ; Cho, Michael ; Lin, Keng Han ; Brody, Jennifer ; Seidman, Christine ; Ratan, Aakrosh ; Schmidt, Ellen ; Shuldiner, Alan R. ; Ramachandran, Vasan ; Min, Nancy ; Gong, Da-Wei ; LeFaive, Jonathon ; Minster, Ryan L. ; Charles Gu, C. ; Ruczinski, Ingo ; Silver, Brian ; Sandow, Kevin ; Do, Ron ; Lange, Ethan ; Psaty, Bruce ; Pattison, Jessica Tangarone ; Boerwinkle, Eric ; Tang, Hua ; Allred, Nicholette P. ; Kramer, Holly ; Curran, Joanne ; Graham Barr, R. ; Chavan, Sameer ; Laurie, Cecelia ; Applebaum-Bowden, Debora ; Chuang, Lee-Ming ; Curtis, Jeffrey ; Phillips, Larry ; Pankow, James ; Prokopenko, Dmitry ; Becker, Diane ; Qin, Zhaohui ; Almasy, Laura ; Bis, Joshua ; Beer, Rebecca ; Hong, Elliott ; Cardwell, Jonathan ; Natarajan, Pradeep ; Guo, Xiuqing ; Mei, Hao ; Carlson, Sara ; Blangero, John ; Nekhai, Sergei ; Custer, Brian ; Mahaney, Michael ; Albert, Christine ; Kardia, Sharon ; Gabriel, Stacey ; Salzberg, Steven ; Fulton, Lucinda ; Kooperberg, Charles ; Chen, Wei-Min ; Smoller, Sylvia ; Jones, Kimberly ; Franceschini, Nora ; Loos, Ruth ; McArdle, Patrick ; Salimi, Shabnam ; Bunting, Karen ; Boorgula, Meher Preethi ; Casaburi, Richard ; Laurie, Cathy ; Sankaran, Vijay ; Borecki, Ingrid ; Jhun, Min A. ; Nadkarni, Girish ; Duggirala, Ravi ; David, Sean ; Gan, Weiniu ; Barnard, John ; Bezerra, Marcos ; Perez, Marco ; Hawley, Nicola ; Geng, Xiaoqi ; Qiao, Dandi ; Blackwell, Thomas ; Margolin, Lauren ; Huston, Haley ; Reiner, Alex ; Schwander, Karen ; Daya, Michelle ; Auer, Paul ; Hixson, James ; Shetty, Amol ; Devine, Scott ; Burchard, Esteban ; Crapo, James ; Phillips, Sam ; Roselli, Carolina ; Chasman, Daniel ; Montasser, May E. ; Gelb, Bruce ; Gogarten, Stephanie ; Zaghloul, Norann A. ; Kinney, Greg ; Sakornsakolpat, Phuwanat ; Heckbert, Susan ; Wang, Xiaochun ; Cornell, Elaine ; Benjamin, Emelia ; Kaplan, Robert ; Parker, Margaret ; Smith, Tanja ; Anderson, Peter ; Arnett, Donna K. ; Alonso, Alvaro ; Chaffin, Mark ; Russell, Pamela ; Flickinger, Matthew ; Barnes, Kathleen ; Liu, Yongmei ; Mitchell, Braxton ; Sztalryd, Carole ; Becker, Julia Powers ; Duan, Qing ; Choi, Seung Hoan ; Taylor, Simeon ; Musani, Solomon ; Glahn, David ; Dutcher, Susan ; Krauter, Stephanie ; Hokanson, John ; Das, Sayantan ; Heavner, Ben ; Perry, James A. ; Broeckel, Ulrich ; Hersh, Craig ; Lewis, Joshua ; Liu, Simin ; Post, Wendy ; Peyser, Patricia ; Johnson, Craig ; Emery, Leslie ; Rao, D. C. ; Fingerlin, Tasha ; Parsa, Afshin ; Hoth, Karin ; LeBoff, Meryl ; Perry, James ; Goring, Harald ; Qasba, Pankaj ; Reed, Robert ; Sheehan, Vivien ; Fu, Mao ; Anugu, Pramod ; Gao, Yan ; Taub, Margaret ; Kathiresan, Sekar ; Snively, Beverly ; O'Hare, Elizabeth A. ; Jaquish, Cashell E. ; Khan, Alyna ; Taliun, Daniel ; Redline, Susan ; Ida Chen, Yii-Der ; Fornage, Myriam ; Scheller, Christopher ; Schwartz, David ; Lange, Leslie ; Peters, Ulrike ; Bielak, Larry ; Sofer, Tamar ; Gignoux, Chris ; Howard, Alicia D. ; Begum, Ferdouse ; Levine, David ; Lin, Honghuang ; Manson, JoAnn ; Mitchell, Braxton D. ; Rich, Stephen ; Miller, Michael ; Mwasongwe, Stanford ; Ryan, Kathleen A. ; Kessler, Michael ; McDonald, Merry-Lynn ; Hidalgo, Bertha ; Irvin, Marguerite ; He, Jiang ; Jaquish, Cashell ; Streeten, Elizabeth ; Meyers, Deborah ; Hsiung, Chao ; O'Connell, Jeff ; Nickerson, Deborah ; Minear, Mollie ; Ryan, Kathleen ; Silverman, Edwin ; Aslibekyan, Stella ; Rafaels, Nicholas ; Carty, Cara ; Avramopoulos, Dimitrios ; Preuss, Michael ; Lee, Wen-Jane ; Mychaleckyj, Josyf C. ; Smith, Nicholas ; Becker, Lewis ; Deka, Ranjan ; Smith, Jennifer ; Abecasis, Goncalo ; Papanicolaou, George ; Roden, Dan ; Sciurba, Frank ; Rasmussen-Torvik, Laura ; Jackson, Rebecca ; Sung, Yun Ju ; Sylvia, Jody ; Crandall, Carolyn ; Chang, Yen-Pei C. ; Beitelshees, Amber ; Manichaikul, Ani ; Haessler, Jeff ; Chung, Mina ; DeBaun, Michael ; Smith, Josh ; Kaufman, Laura ; Gass, Margery ; Herrington, David ; Johnston, Rich ; Shetty, Aniket ; Naik, Rakhi Johns ; Benjamin Shoemaker, M.

Background:Elevated levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for cardiovascular disease via its contribution to the development and progression of atherosclerotic lesions. Although the genetic basis of LDL-C has been studied extensively, currently known genetic variants account for only ≈20% of the variation in LDL-C levels.Methods:Through an array-based association analysis in 1102 Amish subjects, we identified a variant strongly associated with LDL-C levels. Using a combination of genetic analyses, zebrafish models, and in vitro experiments, we sought to identify the causal gene driving this association.Results: We identified a founder haplotype associated with a 15 mg/dL increase in LDL-C on chromosome 5. After recombination mapping, the associated region contained 8 candidate genes. Using a zebrafish model to evaluate the relevance of these genes to cholesterol metabolism, we found that expression of the transcribed pseudogene, APOOP1 , increased LDL-C and vascular plaque formation. Conclusions: Based on these data, we propose that APOOP1 regulates levels of LDL-C in humans, thus identifying a novel mechanism of lipid homeostasis.

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APOOP1

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