LITAF

Last update 08 May 2025

Basic Info

Synonyms

FLJ38636, lipopolysaccharide induced TNF factor, Lipopolysaccharide-induced tumor necrosis factor-alpha factor

+ [7]

Introduction

Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades (PubMed:23166352). Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429). May also contribute to the regulation of gene expression in the nucleus (PubMed:10200294, PubMed:15793005). Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines (PubMed:15793005). May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10 (PubMed:10200294, PubMed:15793005).

100 Clinical Results associated with LITAF

100 Translational Medicine associated with LITAF

0 Patents (Medical) associated with LITAF

529

Literatures (Medical) associated with LITAF

01 May 2025·Developmental & Comparative Immunology

EXOC8 of Epinephelus coioides involved in SGIV infection via innate immunity and apoptosis

Article

Author: Zhang, Ze-Peng ; Jiang, Yu-Feng ; Lan, Yin-Mei ; Huang, Wei ; Chen, Zi-An ; Sun, Hong-Yan ; Li, Qi-Yin ; Lin, Yun-Xiang ; Huang, Cui-Fen ; Qin, Qi-Wei

The exocyst complex (EXOC) plays a major role in the extracellular secretion of organisms. In this study, EXOC8, a member of the EXOC family, was characterized from Epinephelus coioides,an important economical important fish in southern China and Southeast Asia, and its role response to viral infection was explored. The full length of E. coioides EXOC8 is 3091 bp including a 2061 bp open reading frame (ORF) encoding 686 amino acids, with a molecular mass of 79037.42 Da. The mRNA of E. coioides EXOC8 can be detected in all of the tissues examined with different levels. E. coioides EXOC8 is distributed in the cytoplasm. The expression of E. coioides EXOC8 was up-regulated during Singapore grouper iridovirus (SGIV) infection, an important pathogen of E. coioides. Overexpressing E. coioides EXOC8 significantly promoted the formation of cytopathic effects (CPE) caused by SGIV infection and the expressions of SGIV key genes MCP, VP19, LITAF and ICP18; but significantly inhibited the activities of NF-κB/AP-1 promoter, apoptosis induced by SGIV, and the expressions of inflammatory factors (IL-6,IL-8, IL-1β and TNF-α) in E. coioides. The results demonstrated that E. coioides EXOC8 may be involved in SGIV infection, providing a theoretical basis for clearing the mechanisms of viral infection in fish.

01 Apr 2025·International Dental Journal

Uncovering Molecular and Genetic Drivers of Dental Caries Via scRNA-seq and Mendelian Randomisation

Article

Author: Wang, Jian ; Yu, Zijing ; Xu, Wenpin ; Bian, Qinjiang ; Li, Zhiwei ; Guo, Chao

BACKGROUNDDental caries remains a prevalent oral health problem globally, influenced by environmental, genetic, and microbial factors. Traditional studies have emphasised microbial colonisation and dietary sugars, neglecting the intricate molecular and genetic interactions. This study aimed to integrate single-cell RNA sequencing (scRNA-seq) with Mendelian randomisation (MR) to elucidate the molecular and genetic factors contributing to the susceptibility and progression of dental caries.MATERIALS AND METHODSWe utilised scRNA-seq data from the GSE185222 dataset, comprising both healthy and caries-affected dental pulp tissues, to profile cellular heterogeneity and gene expression. We then applied MR to identify genetic variants linked to caries risk, using Single Nucleotide Polymorphisms (SNPs) as instrumental variables to infer causal relationships between identified genes and caries incidence.RESULTSOur analyses revealed significant cellular diversity within the dental pulp and identified six key genes (CSF1R, GPX3, LITAF, PLAU, ST8SIA4, and TBXAS1) associated with caries risk. These genes are implicated in immune regulation, oxidative stress response, and tissue remodelling, highlighting a complex interplay between host defense mechanisms and microbial presence. Further, our MR analysis confirmed the causal influence of these genetic variants on caries risk, offering new insights into the genetic predisposition to dental caries.CONCLUSIONBy combining scRNA-seq with MR, this study provides a comprehensive molecular and genetic framework for understanding dental caries. Our findings suggest that targeting these pathways could enhance prevention and treatment strategies, paving the way for precision medicine in dental care. Future research should explore these genes' functional roles in caries progression and their potential as biomarkers for early detection and therapeutic targeting.

01 Feb 2025·Virology

The regulatory role of Epinephelus Coioides miR-21 in the infection and replication of iridovirus SGIV

Article

Author: Zhang, Ze-Peng ; Lan, Yin-Mei ; Huang, Cui-Fen ; Huang, Wei ; Li, Pin-Hong ; He, Ru-Nan ; Lin, Yun-Xiang ; Sun, Yan-Hong ; Qin, Qi-Wei ; Lei, Yu-Rong ; Chen, Zi-An

Iridovirus SGIV is a highly pathogenic virus of fish that can cause more than 90% mortality in Epinephelus coioides, a marine farmed fish in South China. miRNAs can be involved in regulating the development of virus-induced diseases. In this study, SGIV infection could significantly inhibit the expression of E. coioides miR-21. And, overexpressing miR-21 could inhibit the expressions of viral key genes (ICP18, VP19, LITAF and MCP), SGIV-induced CPE, and viral titers. Overexpression of miR-21 promoted the promoter activity of AP-1/NF-κB, SGIV-induced apoptosis, and activities of caspase 3/9. Inhibiting miR-21 could produce the opposite results. E. Coioides PDCD4 is a targeting gene of miR-21, and we speculate that PDCD4 downregulation may, at least in part, explain the observed antiviral effects. These studies indicate that miR-21 could inhibit the infection and replication of SGIV, which might provide a molecular basis for further exploring the mechanism of SGIV invasion.

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LITAF

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