SERPINB5

Last update 08 May 2025

Basic Info

Synonyms

maspin, Peptidase inhibitor 5, PI-5

+ [4]

Introduction

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

100 Clinical Results associated with SERPINB5

100 Translational Medicine associated with SERPINB5

0 Patents (Medical) associated with SERPINB5

994

Literatures (Medical) associated with SERPINB5

01 Dec 2025·Molecular Biology Reports

The paradoxical role of SERPINB5 in gastrointestinal cancers: oncogene or tumor suppressor?

Review

Author: Zhang, Jiayu ; Jiang, Wanyi ; Zeng, Shuyan ; Zeng, Chunyan

BACKGROUNDSERPINB5, also known as Maspin, is a non-inhibitory member of the serine protease inhibitor superfamily. SERPINB5 exerts diverse effects on a variety of human cancers, including cell proliferation, angiogenesis, apoptosis, tumor invasion, and metastasis. SERPINB5 has traditionally been regarded as a tumor suppressor gene, but emerging evidences supports its oncogenic properties.METHODSWe conducted a comprehensive review of the existing literature on SERPINB5 in gastrointestinal cancers, synthesizing data on its expression patterns, subcellular localization, epigenetic modifications, and clinical significance.RESULTSDepending on its subcellular localization and epigenetic modifications, SERPINB5 demonstrate either protumor or antitumor activity in different gastrointestinal cancers, such as colorectal cancer, gastric cancer, pancreatic cancer, gallbladder cancer and liver cancer. We elucidate its potential as a predictive and prognostic biomarker, with a focus on its implications for diagnosis, prognosis, and therapeutic intervention, emphasizing its utility in early lesion detection and treatment.CONCLUSIONSSERPINB5 plays a complex and context-dependent role in gastrointestinal cancers, highlighting further research to dissect the true significance of SERPINB5 expression and the molecular mechanisms underlying its divergent clinical behaviors in cancer.

01 Dec 2025·Molecular Biology Reports

Correction: The paradoxical role of SERPINB5 in gastrointestinal cancers: oncogene or tumor suppressor?

Author: Zhang, Jiayu ; Jiang, Wanyi ; Zeng, Shuyan ; Zeng, Chunyan

01 Feb 2025·American Journal of Physiology-Cell Physiology

Growth differentiation factor 15 is a glucose-downregulated gene acting as the cross talk between stroma and cancer cells of the human bladder

Article

Author: Feng, Tsui-Hsia ; Hou, Chen-Pang ; Chang, Kang-Shuo ; Lin, Wei-Yin ; Juang, Horng-Heng ; Lin, Yu-Hsiang ; Sung, Hsin-Ching ; Hsu, Shu-Yuan ; Chen, Syue-Ting

This study investigates the counteraction of either CAPE or metformin with the AMPK activity increasing GDF15 expression in human bladder cells. The findings are the first study to indicate the secretion of GDF15 from cancer and stroma cells via autocrine or paracrine mechanisms. Our study suggests that GDF15, an antitumor gene in the human bladder induced by AMPK inducers, acts as a communication link between stroma and cancer cells in the human bladder.

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SERPINB5

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