HAUS7

Last update 08 May 2025

Basic Info

Synonyms

26S proteasome-associated UCH37-interacting protein 1, HAUS augmin like complex subunit 7, HAUS augmin-like complex subunit 7

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Introduction

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

100 Clinical Results associated with HAUS7

100 Translational Medicine associated with HAUS7

0 Patents (Medical) associated with HAUS7

Literatures (Medical) associated with HAUS7

09 May 2023·Scientific reports

A prognostic model based on the Augmin family genes for LGG patients.

Article

Author: Wang, Tao ; Yao, Senbang ; Zhang, Mingjun ; Fei, Xichang ; Li, Siyu

Gliomas are the most prevalent primary tumors in the central nervous system.Despite some breakthroughs in the treatment of glioma in recent years, survival rates remain low.Although genes of the Augmin family play a key role in microtubule nucleation, the role they play in gliomas is unclear.Transcriptome data were extracted from UCSC XENA and GTEx for low-grade glioma (LGG) and normal tissues, resp.The protein interaction network associated with Augmin family genes was established using STRING and GeneMANIA databases.Enrichment anal. of gene-related functions and pathways was used to explore potential biol. pathways and TIMER to assess immune cell infiltration.Regression anal. and Kaplan-Meier anal. were used to look at the clin. characteristics of the Augmin family genes and the association with the prognosis of patients with glioma.The results showed that the mRNA expression of Augmin family genes was significantly elevated in LGG tissues, except for HAUS7.Immunoregulation, cell cycle, apoptosis and other signaling pathways may be involved in the development and progression of LGG.Except for HAUS4 and HAUS7, the expression of all genes was pos. correlated with immune cell infiltration.High expression of HAUS1, HAUS3, HAUS5, HAUS7, HAUS8 and low expression of HAUS4, HAUS6 in LGG was associated with poor prognosis.The risk models constructed based on the pivotal genes HAUS2, HAUS4 and HAUS8 were validated by nomogram and confirmed to be clin. useful for predicting the prognosis of LGG.

03 Jul 2021·Arab Journal of Urology

Current updates and future perspectives in the evaluation of azoospermia: A systematic review

Article

Author: Lamb, Dolores J. ; Punjani, Nahid ; Schlegel, Peter N. ; Kang, Caroline

Objectives: To provide a summary of the current evaluation of azoospermia and insights into future perspectives in the evaluation and counselling of men with azoospermia. Methods: A search of PubMed, Cochrane Reviews and Web of Science databases was performed for full-text English-language articles published between 1943 and 2020 focussing on 'future perspectives', 'azoospermia' and 'evaluation'. Results: Azoospermia represents a severe form of male infertility characterised by sperm production so impaired that there are no sperm present in the ejaculate. The current evaluation of azoospermia focusses on patient history and physical examination with selected adjunctive laboratory investigations including serum hormones, a karyotype and screening for Y chromosome microdeletions. Future diagnostics are focussed on identifying the underlying genetic aetiologies for azoospermia, as well as a greater emphasis on screening for systemic illness that men with severe infertility may be predisposed to develop. Conclusion: Azoospermia represents an extreme form of male infertility, and evaluation relies heavily on history and physical examination, as genetic evaluations for these individuals remain limited. Future evaluation will focus on next-generation sequencing and more rigorous evaluation for possible co-existing and future risk of systemic disease. ABBREVIATIONS: ADGRG2, adhesion G protein-coupled receptor G2; ASRM: American Society of Reproductive Medicine; AZF: azoospermia factor; CBAVD: congenital bilateral absence of the vas deferens; CFTR: cystic fibrosis transmembrane conductance regulator; CRKL: CRK-like proto-oncogene; E2F1: E2F transcription factor 1; HAUS7: HAUS augmin-like complex subunit 7; HR: hazard ratio; KS: Klinefelter syndrome; MAZ, MYC-associated zinc finger protein; NGS: next-generation sequencing; NOA: non-obstructive azoospermia; OA: obstructive azoospermia; RHOX: reproductive homeobox on the X chromosome; SH2: SRC homology 2; TAF7L: TATA-box binding protein associated factor 7-like; TEX11: testis-expressed 11; WES: whole-exome sequencing.

01 Dec 2019·Current BiologyQ1 · BIOLOGY

Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission

Q1 · BIOLOGY

Article

Author: Kumar, Atul ; Bartolini, Francesca ; Qu, Xiaoyi ; Waites, Clarissa ; Blockus, Heike

Control of microtubule (MT) nucleation and dynamics is critical for neuronal function. Whether MT nucleation is regulated at presynaptic boutons and influences overall presynaptic activity remains unknown. By visualizing MT plus-end dynamics at individual excitatory en passant boutons in axons of cultured hippocampal neurons and in hippocampal slices expressing EB3-EGFP and vGlut1-mCherry, we found that dynamic MTs preferentially grow from presynaptic boutons, show biased directionality in that they are almost always oriented toward the distal tip of the axon, and can be induced by neuronal activity. Silencing of γ-tubulin expression reduced presynaptic MT nucleation, and depletion of either HAUS1 or HAUS7-augmin subunits increased the percentage of retrograde comets initiated at boutons, indicating that γ-tubulin and augmin are required for activity-dependent de novo nucleation of uniformly distally oriented dynamic MTs. We analyzed the dynamics of a wide range of axonal organelles as well as synaptic vesicles (SVs) relative to vGlut1⁺ stable presynaptic boutons in a time window during which MT nucleation at boutons is promoted upon induction of neuronal activity, and we found that γ-tubulin-dependent presynaptic MT nucleation controls bidirectional (SV) interbouton transport and regulates evoked SV exocytosis. Hence, en passant boutons act as hotspots for activity-dependent de novo MT nucleation, which controls neurotransmission by providing dynamic tracks for bidirectional delivery of SVs between sites of neurotransmitter release.

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HAUS7

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