MTF1

Last update 08 May 2025

Basic Info

Synonyms

Metal regulatory transcription factor 1, MRE-binding transcription factor, MTF1

+ [1]

Introduction

Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity).

100 Clinical Results associated with MTF1

100 Translational Medicine associated with MTF1

0 Patents (Medical) associated with MTF1

546

Literatures (Medical) associated with MTF1

01 Jun 2025·Toxicology

Thallium induces metallothionein gene expression in Huh-7 human hepatoma cells

Article

Author: Unuma, Kana ; Aki, Toshihiko ; Funakoshi, Takeshi

Thallium (Tl) is one of the most toxic heavy metals and is found ubiquitously in the earth's crust. To investigate the cellular responses to and against Tl cytotoxicity, we conducted DNA microarray analysis using three human cell lines of different origins: SH-SY5Y (neuroblast-derived), HEK293T (embryonic kidney-derived), and Huh-7 (hepatoma-derived) cells. All of the ten genes that showed the highest inductions in Huh-7 cells treated with 60 µM Tl₂SO₄ for 72 hours are metallothionein (MT) genes. The induction of the MT genes appears specific to Huh-7 cells; increases of 50-140-fold in the ten MT genes were observed in Huh-7 cells, while the increases were less than 4-fold in HEK293T and SH-SY5Y cells by microarray analysis. Investigation of the pathway responsible for Tl₂SO₄-induced MT expression in Huh-7 cells revealed that the RNA interference-mediated forced downregulation of MTF1 transcription factor resulted in the suppression of Tl₂SO₄-induced MT gene expressions, but not Tl₂SO₄-induced cell death, suggesting that MTF1-mediated MT gene expression is insufficient to protect Huh-7 cells against death by Tl₂SO₄. In contrast, the knockdown of nrf1 worsened Tl₂SO₄-induced cell death without suppressing MT gene expressions. These results indicate that MT gene induction in response to Tl₂SO₄ is mediated at least in part by MTF1 in Huh-7 cells. Nevertheless, MT gene induction through MTF1 seems insufficient to prevent the cell death caused by Tl₂SO₄. Nrf1 appears to be involved in protection against Tl₂SO₄ toxicity through mechanisms other than MT gene induction.

01 Apr 2025·International Dental Journal

GLS as a Key Cuproptosis-Related Gene in Periodontitis: Insights from Single-Cell RNA Sequencing

Article

Author: Xiuan, Zhu ; Donglin, Zhang ; Wenjie, Wen

OBJECTIVEThe objective of this study is to investigate the role of cuproptosis-related genes (CRGs) in periodontitis using an integrative approach that combines single-cell RNA sequencing (scRNA-seq) and bioinformatic analyses. The study aims to elucidate the connection between copper-induced cell death (cuproptosis) and periodontitis, a prevalent chronic inflammatory oral disease that leads to tooth-supporting tissue damage and eventual tooth loss.METHODSDifferentially expressed genes (DEGs) were identified from the GSE10334 dataset, leading to the discovery of 14 differentially expressed CRGs associated with periodontitis. Subsequent application of least absolute shrinkage and selection operator (LASSO) regression and logistic regression analysis pinpointed three key CRGs: MTF1, GLS, and DLST. Single-cell sequencing data analysis was further conducted to explore the expression patterns of these genes, particularly GLS, within immune cells and their association with the immune cell network in periodontal tissues.RESULTSThe study revealed that GLS is widely expressed in immune cells and is closely linked to the complex immune cell interactions within periodontal tissues. This finding underscores GLS as a potential therapeutic target in the context of periodontitis, associated with cuproptosis. The integration of single-cell sequencing data highlighted the significant role of cuproptosis in the diversity and complexity of periodontitis pathogenesis.CONCLUSIONThis research advances the understanding of the crosstalk between periodontitis and cuproptosis, emphasising the role of CRGs, especially GLS, in periodontitis. Furthermore, this study on cuproptosis may contribute to future diagnostic and therapeutic strategies for periodontitis.

01 Apr 2025·Journal of Hazardous Materials

Combined exposure to microplastics and copper elicited size-dependent uptake and toxicity responses in red swamp crayfish (Procambarus clarkia)

Article

Author: Wei, Wei ; Zeng, Huixin ; Zhong, Yanfei ; Xu, Xiaoli ; Luo, Mingzhong

In recent years, the toxicity of microplastics (MPs) in combination with heavy metals, particularly the influence of varying microplastic sizes on their toxic effects, has attracted widespread attention. In this study, red swamp crayfish (Procambarus clarkia) were exposed to MPs of two particle sizes (S-MPs: 5 μm, 1 mg/L; and L-MPs: 100 μm, 1 mg/L) and Cu (5 mg/L) individually or in combination for 96 h. The accumulation patterns of MPs were as follows: gills > intestines > hepatopancreas > muscles. Moreover, the accumulation pattern of Cu was as follows: intestines > gills > hepatopancreas > muscle. Additionally, S-MPs and L-MPs enhanced Cu accumulation, with the highest levels observed in the S-MPs+Cu-treated group. Histopathological analysis showed that the combined exposure led to greater hepatopancreatic damage. Assessment of antioxidant enzymes showed decreased activities of superoxide dismutase, catalase, and glutathione among the different treatments, except for malondialdehyde, which was elevated compared to the control group. In the S-MPs+Cu-treated group, the expression levels of Cu homeostasis genes (MTF-1, ATP2, Atox1, MT) were significantly lower than those in the Cu treated group. This study provides a valuable reference for studying the combined toxic effects of MPs with varying particle sizes on heavy metals.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis