LIPN

Last update 08 May 2025

Basic Info

Synonyms

bA186O14.3, lipase family member N, Lipase member N

+ [3]

Introduction

Plays a highly specific role in the last step of keratinocyte differentiation. Contains two distinct domains: the alpha/beta hydrolase fold and the abhydrolase-associated lipase region, also features the consensus sequence of the active site of a genuine lipase. May have an essential function in lipid metabolism of the most differentiated epidermal layers.

100 Clinical Results associated with LIPN

100 Translational Medicine associated with LIPN

0 Patents (Medical) associated with LIPN

Literatures (Medical) associated with LIPN

01 Nov 2024·Journal of the European Academy of Dermatology and Venereology

Comment on "Cholesterol and low‐density lipoprotein as a cause of psoriasis: Results from bidirectional Mendelian randomization"

Letter

Author: Cao, Yi ; Tao, Maocan ; Li, Hui ; Zhou, Qiujun ; Wang, Jinhui ; Wang, Qionglin ; Jin, Xiaoliang

Psoriasis is an inflammatory disease that affects many people.However, the causal effect of lipid metabolism on psoriasis has not yet been verified.This study aimed to identify the genetic relationship between serum lipid levels and psoriasis.Bidirectional two-sample Mendelian randomization (MR) was used to analyze the causal relationship between cholesterol and psoriasis.The outcome of the forward causality test was psoriasis.In the anal. of reverse causality, psoriasis was exposed, and 79 single-nucleotide polymorphisms were detected in the genome-wide association study (GWASs) database from the IEU GWASs Project.MR-Egger regression, inverse variance-weighted, weighted median, weighted mode and simple mode were used for the MR analyses.The level of triglyceride, lipase member N, chylomicrons, extremely large very low-d. lipoprotein (VLDL) particles, high-d. lipoprotein (HDL) cholesterol levels, cholesterol esters in large HDL, cholesterol esters in medium HDL and cholesterol esters in medium VLDL have not affected the development of psoriasis.However, total cholesterol, total free cholesterol, low-d. lipoprotein (LDL) cholesterol levels, cholesterol esters in large VLDL and cholesterol esters in medium LDL were unidirectional causal effects on psoriasis.Bidirectional two-sample MR anal. indicated that high levels of total cholesterol, total free cholesterol, LDL cholesterol, cholesterol esters in large VLDL and cholesterol esters in medium LDL are genetic risk factors for psoriasis.

01 Apr 2024·Journal of the European Academy of Dermatology and Venereology

Cholesterol and low‐density lipoprotein as a cause of psoriasis: Results from bidirectional Mendelian randomization

Article

Author: Zhou, Qiujun ; Li, Hui ; Cao, Yi ; Tao, Maocan ; Wang, Qionglin ; Wang, Jinhui ; Jin, Xiaoliang

AbstractBackgroundPsoriasis is an inflammatory disease that affects many people. However, the causal effect of lipid metabolism on psoriasis has not yet been verified. This study aimed to identify the genetic relationship between serum lipid levels and psoriasis.MethodsBidirectional two‐sample Mendelian randomization (MR) was used to analyse the causal relationship between cholesterol and psoriasis. The outcome of the forward causality test was psoriasis. In the analysis of reverse causality, psoriasis was exposed, and 79 single‐nucleotide polymorphisms were detected in the genome‐wide association study (GWASs) database from the IEU GWASs Project. MR‐Egger regression, inverse variance‐weighted, weighted median, weighted mode and simple mode were used for the MR analyses.ResultsThe level of triglyceride, lipase member N, chylomicrons, extremely large very low‐density lipoprotein (VLDL) particles, high‐density lipoprotein (HDL) cholesterol levels, cholesterol esters in large HDL, cholesterol esters in medium HDL and cholesterol esters in medium VLDL have not affected the development of psoriasis. However, total cholesterol, total free cholesterol, low‐density lipoprotein (LDL) cholesterol levels, cholesterol esters in large VLDL and cholesterol esters in medium LDL were unidirectional causal effects on psoriasis.ConclusionBidirectional two‐sample MR analysis indicated that high levels of total cholesterol, total free cholesterol, LDL cholesterol, cholesterol esters in large VLDL and cholesterol esters in medium LDL are genetic risk factors for psoriasis.

11 Apr 2023·ACS omega

Sequence and Structural Motifs Controlling the Broad Substrate Specificity of the Mycobacterial Hormone-Sensitive Lipase LipN.

Article

Author: Schemenauer, Daniel E. ; Johnson, R. Jeremy ; Pool, Emily H. ; Kourtoglou, Elexi C. ; Raynor, Stephanie N. ; Durand, Anthony J. ; Hoops, Geoffrey C. ; Esteb, John J. ; Ruiz, Gabriela P. ; Goehring, Leah M. ; Wilson, Madeleine A. ; Larsen, Erik M. ; Lavis, Luke D. ; Koelper, Andrew J.

Mycobacterium tuberculosis has a complex life cycle transitioning between active and dormant growth states depending on environmental conditions. LipN (Rv2970c) is a conserved mycobacterial serine hydrolase with regulated catalytic activity at the interface between active and dormant growth conditions. LipN also catalyzes the xenobiotic degradation of a tertiary ester substrate and contains multiple conserved motifs connected with the ability to catalyze the hydrolysis of difficult tertiary ester substrates. Herein, we expanded a library of fluorogenic ester substrates to include more tertiary and constrained esters and screened 33 fluorogenic substrates for activation by LipN, identifying its unique substrate signature. LipN preferred short, unbranched ester substrates, but had its second highest activity against a heteroaromatic five-membered oxazole ester. Oxazole esters are present in multiple mycobacterial serine hydrolase inhibitors but have not been tested widely as ester substrates. Combined structural modeling, kinetic measurements, and substitutional analysis of LipN showcased a fairly rigid binding pocket preorganized for catalysis of short ester substrates. Substitution of diverse amino acids across the binding pocket significantly impacted the folded stability and catalytic activity of LipN with two conserved motifs (HGGGW and GDSAG) playing interconnected, multidimensional roles in regulating its substrate specificity. Together this detailed substrate specificity profile of LipN illustrates the complex interplay between structure and function in mycobacterial hormone-sensitive lipase homologues and indicates oxazole esters as promising inhibitor and substrate scaffolds for mycobacterial hydrolases.

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LIPN

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